About
Contact & Profiles
A5007321984
Research Areas
- Microbial Natural Products and Biosynthesis
- Steroid Chemistry and Biochemistry
- Computational Drug Discovery Methods
- Synthetic Organic Chemistry Methods
- Enzyme Structure and Function
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- RNA and protein synthesis mechanisms
Wilfrid Laurier University
2019
McMaster University
2018
10.1016/j.chembiol.2018.01.009
article
EN
publisher-specific-oa
Cell chemical biology
2018-02-01
Phosphonates are rare and unusually bioactive natural products. However, most bacterial phosphonate biosynthetic capacity is dedicated to tailoring cell surfaces with molecules like 2-aminoethylphosphonate (AEP). Although phosphoenolpyruvate mutase (Ppm)-catalyzed installation of C-P bonds known, subsequent phosphonyl (Pnt) pathway steps remain enigmatic. Here we identify nucleotidyltransferases in over two-thirds gene clusters, including direct fusions ~60% Ppm enzymes. We characterize two...
10.1038/s41467-019-11627-6
article
EN
cc-by
Nature Communications
2019-08-16
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