A5061184830- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Carcinogens and Genotoxicity Assessment
- Atherosclerosis and Cardiovascular Diseases
- Evolution and Genetic Dynamics
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics and Chromatin Dynamics
Universidad Autónoma de Madrid
2019-2024
Hospital Universitario Fundación Jiménez Díaz
2024
Sex chromosomes of eutherian mammals are highly different in size and gene content, share only a small region homology (pseudoautosomal region, PAR). They thought to have evolved through an addition-attrition cycle involving the addition autosomal segments sex their subsequent differentiation. The events that drive this process difficult investigate because almost all at very advanced stage Here, we taken advantage recent translocation autosome both African pygmy mouse Mus minutoides, which...
X and Y chromosomes in mammals are different size gene content due to an evolutionary process of differentiation degeneration the chromosome. Nevertheless, these usually share a small region homology, pseudoautosomal (PAR), which allows them perform partial synapsis undergo reciprocal recombination during meiosis, ensures their segregation. However, some mammalian species PAR has been lost, challenges pairing segregation sex meiosis. The African pygmy mouse Mus mattheyi shows completely...
ABSTRACT Sex chromosomes of eutherian mammals are highly different in size and gene content, share only a small region homology (pseudoautosomal region, PAR). They thought to have evolved through an addition-attrition cycle involving the addition autosomal segments sex their subsequent differentiation. The events that drive this process difficult investigate because most at very advanced stage Here, we taken advantage recent translocation autosome both African pygmy mouse Mus minutoides ,...
Neointimal hyperplasia is the main cause of vascular graft failure in medium term. NFκB a key mediator inflammation that activated during neointimal following endothelial injury. However, molecular mechanisms involved activation are poorly understood. may be through canonical (transient) and non-canonical (persistent) pathways. NFκB-inducing kinase (NIK, MAP3K14) upstream pathway. We have now explored impact NIK deficiency on guidewire-induced cell injury local by comparing...