A5011310273- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Environmental Justice and Health Disparities
- Thyroid Disorders and Treatments
- Endometriosis Research and Treatment
- Metabolomics and Mass Spectrometry Studies
- Demographic Trends and Gender Preferences
- Urological Disorders and Treatments
- Cancer Risks and Factors
- Global Maternal and Child Health
- Chemical Analysis and Environmental Impact
- Emergency and Acute Care Studies
- Ovarian function and disorders
- Health, Environment, Cognitive Aging
- Hypothalamic control of reproductive hormones
- Animal testing and alternatives
- Travel-related health issues
- Menstrual Health and Disorders
- Gestational Diabetes Research and Management
- Statistical Methods and Bayesian Inference
Emory University
2014-2024
Georgia Department of Public Health
2010-2021
Prenatal exposures to polyfluoroalkyl compounds (PFCs) may be associated with adverse changes in fetal and postnatal growth.
Background: In 1973–1974, Michigan residents were exposed to polybrominated biphenyls (PBBs) through an accidental contamination of the food supply. Residents enrolled in a registry assembled after incident, and they their children participated follow-up studies assess subsequent health outcomes. Objectives: We evaluated associations between serum PBBs polychlorinated (PCBs) markers thyroid function among adults. Methods: Serum concentrations four PBB PCB congeners measured at least once 753...
Widespread polybrominated biphenyls (PBBs) contamination occurred in Michigan from 1973 to 1974, when PBBs were accidentally substituted for a nutritional supplement livestock feed. People who lived the state exposed via several routes including ingestion, inhalation and skin absorption. sequestered lipid-rich matrices such as adipose tissue, are slowly eliminated after entering human body, can also be transferred mother her offspring through placenta breastfeeding. Due long biological...
Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated (PCB). A growing body of evidence suggests that exposure certain compounds may affect thyroid function, especially in people as children, but there are conflicting observations. In this study, we extend previous work by examining age exposure's effect on the relationship between PBB function a large group individuals PBB. Linear regression models used test association...
In 1973, Michigan residents were exposed to polybrominated biphenyl (PBB) when it was accidentally added farm animal feed. Highly individuals and their children have experienced endocrine-related health problems, though the underlying mechanism behind these remains unknown. We investigated whether PBB exposure is associated with variation in DNA methylation peripheral blood samples from 658 participants of registry using MethylationEPIC BeadChip, as well what potential function affected...
In 1973, the Velsicol Chemical Company, which manufactured FireMaster, a brominated flame retardant, and NutriMaster, nutritional supplement, mistakenly shipped hundreds of pounds FireMaster to grain mills around Michigan where it was incorporated into animal feed then food chain across state. An estimated 6.5 million residents consumed polybrominated biphenyl (PBB)-laced products leading one largest agricultural accidents in U.S. history. To date, there have been no studies investigating...
BackgroundThe upward trend in industrial nations the incidence of male genitourinary (GU) conditions may be attributed to increased exposure endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected disruptor.ObjectiveWe investigated relationship between maternal serum levels PBBs and GU among offspring exposed utero.MethodsIn this cohort study sons born women accidentally during 1973–1974, we examined self-reported data on relation PBB levels....
Objective: Because many emergency medicine (EM) attending physicians believe the time demands of clinical productivity limit their ability to effectively teach medical students in department (ED), purpose this study was determine if there is an inverse relationship between and teaching evaluations. Methods: The authors conducted a prospective, observational, double‐blind study. They asked senior enrolled EM clerkship evaluate each physician who precepted them at three academic EDs. After...
Abstract Background Previous studies have reported that hyperthyroid and hypothyroid women experience menstrual irregularities more often compared with euthyroid women, but reasons for this are not well‐understood on thyroid hormones among lacking. In a prospective cohort study of characterised the relationship between hormone concentrations prospectively collected function outcomes. Methods Between 2004‐2014, 86 premenopausal lactating or taking hormonal medications participated in...
Abstract In 1973, accidental contamination of Michigan livestock with polybrominated biphenyls (PBBs) led to the establishment a registry exposed individuals that have been followed for > 40 years. Besides being PBBs, this cohort has also polychlorinated (PCBs), structurally similar class environmental pollutants, at levels average US exposure. study, we examined association between current serum PCB and PBB various female reproductive health outcomes build upon previous work...
ABSTRACT The authors studied 194 women exposed to polybrominated biphenyls (PBB) in utero when their mothers consumed products accidentally contaminated Michigan 1973. Generalized estimating equations were used examine the effect of PBB exposure on adult pregnancy-related outcomes. Compared those with lowest (≤1 ppb), mid-range (>1–3.16 ppb) and high (≥3.17 had increased odds spontaneous abortion wide confidence intervals (odds ratio [OR] = 2.75, 95% interval [CI] 0.64–11.79, OR 4.08, CI...
In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30 years following exposure. residents were enrolled a study cohort after exposure polybrominated biphenyls (PBBs) through consumption of contaminated food products. PBB concentrations measured serum at time enrolment. Cancer was determined by linkage Registry. We conducted nested case–control that included 51 diagnosed with during 1974–2004 and 202...
Background: Polybrominated biphenyls (PBB) and polychlorinated (PCB) are persistent organic pollutants with potential endocrine-disrupting effects linked to adverse health outcomes. Objectives: In this study, we utilize high-resolution metabolomics (HRM) identify internal exposure biological responses underlying PCB multigenerational PBB for participants enrolled in the Michigan Registry. Methods: HRM profiling was conducted on plasma samples collected from 2013 2014 a subset of Registry,...
Polybrominated biphenyl (PBB), a brominated flame retardant, was accidently mixed into animal feed in Michigan (1973–1974) resulting human exposure through consumption of contaminated meat, milk and eggs. Beginning 1976 individuals who consumed products were enrolled the Long-Term PBB Study. This cohort presents unique opportunity to study association between parental exposures offspring sex ratio. We identified female participants (born 1975–1988) obtained electronic birth records for those...
Exposure to polychlorinated biphenyls (PCBs), an endocrine-disrupting compound, is ubiquitous despite decades-old bans on the manufacture and use of PCBs. Increased exposure PCBs associated with adverse health consequences throughout life, including type 2 diabetes cancer. PCB also alterations in epigenetic marks gene transcription, which could lead outcomes, but many these are population-specific. To further investigate association between marks, DNA methylation was measured at 787,684 CpG...
To safely resume sports, college and university athletic programs regional conferences created plans to mitigate transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Mitigation measures included physical distancing, universal masking, maximizing outdoor activity during training; routine testing; 10-day isolation persons with COVID-19; 14-day quarantine athletes identified as close contacts* confirmed COVID-19. Regional testing policies based on National...
Aim: Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added the food supply. Highly individuals report sex-specific health problems, but underlying biological mechanism behind these different risks is not known. Materials and methods: DNA methylation in blood from 381 women 277 men with PBB exposure analyzed MethylationEPIC BeadChip. Results: 675 CpGs associated PBBs levels males, while only 17 females (false discovery rate <0.05). No both sexes....