A5032675353- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- Porphyrin and Phthalocyanine Chemistry
- Organic Light-Emitting Diodes Research
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Nonlinear Optical Materials Studies
- Photochemistry and Electron Transfer Studies
- Click Chemistry and Applications
- Photonic Crystals and Applications
- Random lasers and scattering media
- DNA and Nucleic Acid Chemistry
- Extracellular vesicles in disease
- Polydiacetylene-based materials and applications
- Molecular spectroscopy and chirality
- Covalent Organic Framework Applications
- Chemical Reactions and Mechanisms
- Synthesis and properties of polymers
- Optical Coherence Tomography Applications
- Dyeing and Modifying Textile Fibers
- ATP Synthase and ATPases Research
- Advanced Fluorescence Microscopy Techniques
- Photochromic and Fluorescence Chemistry
Universidad Complutense de Madrid
2009-2025
Royal College of Surgeons in Ireland
2017-2024
Universidad Autónoma de Madrid
2020-2023
22q11 Ireland
2018
Consejo Superior de Investigaciones Científicas
2012
Abstract A series of mono‐ to hexachlorinated BODIPY dyes have been prepared in good excellent yields through the use N ‐chlorosuccinimide as an inexpensive halogenating reagent. This library chlorinated allowed analysis detail, from experimental and theoretical points view, dependency photophysical optical properties on number positions chlorine substituents their cores. Quantum mechanical calculations predict regioselectivity halogenation reaction explain why some are less prone...
New BODIPY dyes with two 4-formylphenyl, 4-(2,2-dimethoxycarbonylvinyl)phenyl and 4-(2,2-dicyanovinyl)phenyl groups at the 3- 5-positions have been successfully designed synthesized via palladium-catalyzed coupling reaction or Knoevenagel-type condensations. Structural modification of core conjugation-extending residues significantly affects spectroscopy photophysical properties fluorophore. These substituents cause largest bathochromic shift in both absorption emission spectra, which are...
Abstract A new library of E ‐ and C ‐4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐ s ‐indacene (BODIPY) derivatives has been synthesized through a straightforward protocol from commercially available BODIPY complexes, systematic study the photophysical properties laser behavior related to electronic B‐substituent group (alkynyl, cyano, vinyl, aryl, alkyl) carried out. The replacement fluorine atoms by electron‐withdrawing groups enhances fluorescence response dye, whereas electron‐donor diminish...
Abstract A new and facile strategy for the development of photonic materials is presented that fufills conditions being efficient, stable, tunable laser emitters over visible region spectrum, with possibility easily processable cost‐effective. This approach uses poly(methyl methacrylate) (PMMA) as a host dyes improved efficiency photostability synthesized. Using simple protocol, fluorine atoms in commercial (4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene) ( F ‐BODIPY) by carboxylate groups. The...
Coumarin–BODIPY energy transfer laser dyes have been designed and tested as versatile, tunable photostable active media for UV irradiation.
The synthetically convenient strain promoted double azide cycloaddition of the Sondheimer‐Wong diyne produces resolvable chiral dibenzo‐cycloocta‐bis‐triazoles whose stereogenicity, to date, has gone unrecognised. Enantiomers were separable by HPLC and showed no racemization at 100 °C. This unique method produce substrates was exploited for synthesis resolution a fluorescent BF2‐azadipyrromethene, with absorption emission spanning important spectral range 600 700 nm. fluorophore properties...
We establish an efficient strategy to optimize the performance of dye-doped host materials consisting analyzing in a systematic way dependence their Amplified Spontaneous Emission (ASE) efficiency and photostability on composition structure matrices, selected specifically avoid thermal and/or chemical (photooxidation) processes, main mechanisms dye photodegradation. For this study, number experimental polyimides have been chosen as matrix behavior has compared with that poly(methyl...
The generality of the palladium-catalyzed C-C coupling Negishi reaction when applied to haloBODIPYs is demonstrated on basis selected starting BODIPYs, including polyhalogenated and/or asymmetrical systems, and organozinc reagents. This an interesting synthetic tool in BODIPY chemistry, mainly because it allows a valuable regioselective postfunctionalization chromophores with different functional groups. In this way, patterns that are difficult obtain by other procedures (e.g.,...
Large π-conjugated systems are key in the area of molecular materials. Herein, we prepare via AuI -catalyzed cyclization a series fully anthracene-fused oligo-BODIPYs. Their structural and optoelectronic properties were studied by several techniques, ranging from X-ray, UV/Vis, cyclic voltammetry to transient absorption spectroscopy. As complement, their electronic structures explored means Density Functional Theory (DFT) calculations. Depending on size shape skeleton, unique features-such...
Pt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with photocytotoxicity BODIPYs. Additional conjugation targeting ligands can boost uptake by cancer cells that overexpress corresponding receptors. We describe two triangles, 1 and 2, built pyridyl BODIPYs functionalized glucose (3) or triethylene glycol methyl ether (4), respectively. Both 2 showed higher singlet oxygen quantum yields than 3 4, due to enhanced singlet-to-triplet intersystem crossing. To evaluate effect...
Unprecedented Negishi reaction in haloBODIPYs to yield alkyl, aryl and alkynyl BODIPY dyes, including interesting a symmetrically disubstituted derivatives, is described.
Here we report gold(<sc>i</sc>)-catalyzed cycloisomerization as a new powerful synthetic tool for the preparation of π-extended BODIPY derivatives.
A rational design of an unprecedented asymmetric cassette triad based entirely on BODIPY chromophores allows efficient light harvesting over the UV-vis spectral region, leading to a bright and stable red-edge laser emission via energy-transfer processes.
The reactive partnership between azides and strained alkynes is at the forefront of bioorthogonal reactions, with their
The recognition of the biological, diagnostic and medical importance exosomes has given rise to an urgent need for efficient labelling these extracellular vesicles in ways that do not alter their inherent characteristics. We report first time endogenous method NIR-fluorescent labelled using amphiphilic probe without immunolabelling or synthetic chromatographic manipulation exosomes. Comparative analyses unlabelled with NTA, AFM, flow cytometry immunoblot analysis all show a high degree...
Perylene red decorated by suitable energy donors as an efficient photoactive medium for tunable and red-emitting transfer dye lasers.
The direct and simple fluorination of representative organic laser dyes with emission covering the entire visible spectrum, from blue to red, including Coumarin 460, Pyrromethene 546, Rhodamine 6G Perylene Red, enhances efficiencies by a factor up 1.8 respect corresponding non-fluorinated parent dyes. More importantly, also significantly photostability dyes, even under drastic pumping conditions.
Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt water with changes fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable confocal STED super-resolution imaging bioorthogonal response to detected cellular compartments. These results will encourage broader examination sensing uses aza-dipyrrins.
Previous studies have led to the conclusion that a large majority of acyclic 1,4-dienes do not undergo photochemical di-pi-methane (DPM) rearrangement under triplet-sensitized irradiation. The results detailed analysis these processes demonstrate series compounds indeed highly efficient DPM from their triplet excited states when suitable sensitizers are used.