Aaron D. G. Campbell
A5065591208- interferon and immune responses
- Axial and Atropisomeric Chirality Synthesis
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Molecular spectroscopy and chirality
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Crystal structures of chemical compounds
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- HIV/AIDS drug development and treatment
Newcastle University
2023-2025
Abstract Atropisomeric molecules are a privileged class of stereogenic material that have important applications in catalysis, materials science and medicines. To date, the majority work has been focused upon biaryl heterobiaryl scaffolds involving restricted rotation between pair cyclic fragments, but C–N atropisomeric based amines amides, where nitrogen atom is not part ring system, rapidly emerging as an molecules. This focus this Short Review, which begins by discussing factors influence...
A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised chemists and data scientists used protein structure from fragment-screening paired with advanced machine learning methods each up 100 inhibitory ligands. Across all teams, 1957 compounds were predicted subsequently procured commercial catalogs...
A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised chemists and data scientists used protein structure from fragment-screening paired with advanced machine learning methods each up 100 inhibitory ligands. Across all teams, 1957 compounds were predicted subsequently procured commercial catalogs...
A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised chemists and data scientists used protein structure from fragment-screening paired with advanced machine learning methods each up 100 inhibitory ligands. Across all teams, 1957 compounds were predicted subsequently procured commercial catalogs...
The synthetically convenient strain promoted double azide cycloaddition of the Sondheimer‐Wong diyne produces resolvable chiral dibenzo‐cycloocta‐bis‐triazoles whose stereogenicity, to date, has gone unrecognised. Enantiomers were separable by HPLC and showed no racemization at 100 °C. This unique method produce substrates was exploited for synthesis resolution a fluorescent BF2‐azadipyrromethene, with absorption emission spanning important spectral range 600 700 nm. fluorophore properties...
Novel atropisomeric N -chloroamides were prepared by efficient halogenation reactions and shown to racemize via a pathway involving geared bond rotation.
Four-component reactions at room temperature delivered C–N atropisomeric peptide analogues possessing both central and axial chirality with complete diastereocontrol. Reactions elevated selectively afforded the other diastereoisomer.