A5056192021- Pharmacogenetics and Drug Metabolism
- Chemical Reactions and Isotopes
- Microbial bioremediation and biosurfactants
- Analytical Chemistry and Chromatography
- Plant-based Medicinal Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Chemical Synthesis and Reactions
- Plant tissue culture and regeneration
- Sulfur-Based Synthesis Techniques
- Radioactive contamination and transfer
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Synthesis of Indole Derivatives
- Education in Diverse Contexts
- Per- and polyfluoroalkyl substances research
- Eicosanoids and Hypertension Pharmacology
- Methemoglobinemia and Tumor Lysis Syndrome
- Radioactivity and Radon Measurements
- Natural Compounds in Disease Treatment
- Bone Tissue Engineering Materials
- Chemical Reactions and Mechanisms
- Distributed systems and fault tolerance
- Poisoning and overdose treatments
- Inflammatory mediators and NSAID effects
Charles University
1998-2021
Czech Academy of Sciences, Institute of Biotechnology
1990
Institute of Chemical Technology
1986
Sanguinarine is an alkaloid with known antibiotic and anti-inflammatory activity its pharmacokinetics have been studied in the rat after a single oral dose (10 mg kg−1 body weight). Alkaloid determination plasma liver was carried out by high-performance liquid chromatography–electrospray ionization mass spectrometry (HPLC/ESI-MS). The pharmacokinetic parameters (tmax, cmax, AUC0→t AUC0→∞) were determined for sanguinarine dihydrosanguinarine, major components detected plasma. first step...
Efficient copper mediated arylation of sugar thiols by o-haloaryl triazenes under mild conditions is described. The developed method allows the preparation symmetrical and unsymmetrical 1,3-bis(glycopyranosylthio)benzene derivatives.
AbstractThe series of diamondoids: adamantane, diamantane, triamantane, 2-isopropenyl-2-methyladamantane and 3-isopropenyl-3-methyldiamantane (3-IPMDIA), were employed to elucidate the molecular basis their interaction with active site cytochromes P450 (CYP) a 2B subfamily. These potent inhibitors CYP2B enzymes docked into homology model CYP2B4. Apparent dissociation constants calculated for complexes CYP2B4 diamandoids agreed closely experimental data showing inhibition potency compounds...
Radiopharmaceuticals represent an attractive and efficient treatment of oncological diseases. Medical radionuclide use might bring a particular safety issue with penetration radioactive material into environment via urinal colonal excretion. Therefore, the waste water cleaning decontamination food chain ought to be studied. Radium-223 is FDA EMA approved therapeutic for bone metastases originating from castration resistant prostate cancer. Its introduction clinical praxis opened possibility...
The preparation of iodinated tricyclic antidepressive drug amitriptyline as the substrate for isotopic exchange labelling is described. Direct iodination 10,11-dihydro-5 H -dibenzo[ a,d ]-cycloheptene-5-one leads mainly to 3,7-diiododerivative ( III ). Its structure was confirmed by means single crystal X-ray diffraction analysis: monoclinic, P2 1 / c ; a = 13.315(2), b 7.852(1), 13.584(2) Å, β 103.67(2)°, Z 4, R 0.064 2 474 observed independent reflections. Iodinated ketone transformed...
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Condensation of 2,3,3-trimethyl-3 H -indole ( I ) with 1,2-dibromoethane gave base V , affording perchlorate III . In strongly acid solutions both the and its got converted into disalt IV
Abstract Unconjugated bilirubin (UCB) is the end-product of heme catabolism in intravascular compartment. Although beneficial for human health when mildly elevated body, present at greater than a critical threshold concentration, UCB exerts toxic effects that are related to its physico-chemical properties, particularly affecting central nervous system. The aim study was characterize bilirubin-10-sulfonate (ranarubin), naturally occurring bile pigment, including determination mixed acidity...
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