A5045863759- Ion channel regulation and function
- Bone health and treatments
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Toxin Mechanisms and Immunotoxins
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Circadian rhythm and melatonin
- Multiple Myeloma Research and Treatments
- Biochemical effects in animals
- Bone and Joint Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
Nuffield Orthopaedic Centre
2022
University of Oxford
2022
University of Siena
2010-2013
University of Padua
2011
Ca2+ release, which is necessary for muscle contraction, occurs at the j-SR (junctional domain of sarcoplasmic reticulum). It requires assembly a large multiprotein complex containing RyR (ryanodine receptor) and additional proteins, including triadin calsequestrin. The signals drive these proteins to how they assemble form this are poorly understood. To address aspects questions we studied localization, dynamic properties molecular interactions triadin. We identified three regions, named...
Novel biomarkers for tumour burden and bone disease are required to guide clinical management of plasma cell dyscrasias. Recently, turnover markers (BTMs) Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) have been explored, although their role in the prospective assessment multiple myeloma (MM) monoclonal gammopathy undetermined significance (MGUS) is unclear. Here, we conducted a pilot observational cohort feasibility study combining serum BTMs DW-MRI addition standard assessment....