A5002476381- Prostate Cancer Treatment and Research
- Multiple Myeloma Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Sesame and Sesamin Research
- Phytoestrogen effects and research
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Hematological disorders and diagnostics
- Bone Metabolism and Diseases
- Colorectal Cancer Treatments and Studies
- Bioactive natural compounds
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Nanoparticle-Based Drug Delivery
- Synthesis and bioactivity of alkaloids
- Drug Solubulity and Delivery Systems
- Cancer-related Molecular Pathways
- Psoriasis: Treatment and Pathogenesis
- Autopsy Techniques and Outcomes
- Chromatography in Natural Products
- Machine Learning in Healthcare
Hampshire Hospitals NHS Foundation Trust
2022-2025
Central Drug Research Institute
2024-2025
Chestnut Hill College
2023
Manipal Academy of Higher Education
2019-2022
Basingstoke and North Hampshire Hospital
2019-2022
Narsee Monjee Institute of Management Studies
2021
University of Sheffield
2021
Johns Hopkins University
2014
Abstract Objectives Multi-centre, multi-vendor validation of artificial intelligence (AI) software to detect clinically significant prostate cancer (PCa) using multiparametric magnetic resonance imaging (MRI) is lacking. We compared a new AI solution, validated on separate dataset from different UK hospitals, the original multidisciplinary team (MDT)-supported radiologist’s interpretations. Materials and methods A Conformité Européenne (CE)-marked deep-learning (DL) computer-aided detection...
Introduction Novel injectables possess applications in both local and systemic therapeutics delivery. The advancement utilized materials for construction of complex has tremendously upgraded their safety efficacy.
Abstract Resveratrol obtained in grape seed and skin is structurally similar to a synthetic estrogen diethylstilbestrol. The endogenous estrogen, 17β-estradiol, induces cellular responses by binding the receptor alpha beta. bone fracture due decreased mineral density postmenopausal women linked reduced estrogen. adverse drug reactions of hormone replacement therapy warrant identifying unique natural compounds with ER-subtype specificity improve health. considered phytoestrogen; however, its...
Abstract Background Whole-body (WB) MRI, which includes diffusion-weighted imaging (DWI) and T 1 -w Dixon, permits sensitive detection of marrow disease in addition to qualitative quantitative measurements response treatment bone marrow. We report on the first study embed standardised WB-MRI within a prospective, multi-centre myeloma clinical trial (IMAGIMM trial, sub-study OPTIMUM/MUKnine) explore use detect minimal residual after treatment. Methods The MY-RADS protocol was set up local 1.5...
Abstract Background The Myeloma Response Assessment and Diagnosis System (MY-RADS) guidelines establish a standardised acquisition analysis pipeline for whole-body MRI (WB-MRI) in patients with myeloma. This is the first study to assess image quality multi-centre prospective trial using MY-RADS. Methods cohort consisted of 121 examinations acquired across ten sites range prior WB-MRI experience, three scanner manufacturers two field strengths. Image was evaluated qualitatively by radiologist...
Objective: To evaluate the anticancer potentials of Annona muricata fruit by in vitro and vivo methods. Methods: The ethanolic extract was prepared Soxhlet extraction method further fractionated with petroleum ether, ethyl acetate chloroform. fractions were tested for cytotoxicity, apoptosis, scratch wound assay, cell cycle analysis. IC50, apoptotic index percentage migration determined using HepG2 cells. For studies, hepatocellular carcinoma induced administering 0.01% diethylnitrosamine...
Pharmacognosy Magazine ,2019,15,64,250-255.DOI:10.4103/pm.pm_619_18Published:August 2019Type:Original Article Authors:Aarti Abhishek Shah, Karthik Gourishetti, and Yogendra Nayak Author(s) affiliations:Aarti Department of Pharmacology, Manipal College Pharmaceutical Sciences, Academy Higher Education, Manipal, Karnataka, India Abstract:Background: Resveratrol (RSV) is a polyphenolic phytomolecule naturally present in the skin grapes fruit. It reported to be phytoestrogen because its...
Background: Morphine tolerance on long-term usage leads to chronic pain conditions. Preclinical studies demonstrated that the upregulation of HDACs is associated with a decrease in sensitivity μ-opioid receptors, which results morphine tolerance. Objective: The present study was designed assess influence selected known HDAC inhibitors (NMJ2 and NMJ3) induced by administration Balb/c mice. Methods: In study, administered incremental doses 1, 2, 3.6, 6.5, 11.2, 21, 21 mg/kg daily for seven...
This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy.
Abstract: Background: Trans-resveratrol is a naturally occurring polyphenolic compound extensively marketed as nutraceutical. It highly explored molecule in the research community with vast therapeutic potential. Therefore, many inventions were made by pharma-industries for its clinical use and to bring it market drug. Objectives: In this study, simple, rapid sensitive Reverse Phase High Performance Liquid chromatographic (RP-HPLC) method quantitative determination of resveratrol was...
The clinical application of Doxorubicin (DOX) is restricted due to the incidence myelotoxicity and cardiotoxicity.Damages caused by free radicles cardiac muscle tissues are more permanent.The potent ROS scavenger, Sesamol (SM) has been proven be effective in diseases related oxidative stress.Thus, SM can a good choice for myocardial protection against stress.3′,4′-(Methylenedioxy) acetophenone (3'MA) being derivative have our lab antioxidant.Thus, both 3'MA may having scavenging potential.In...
Introduction: Basingstoke was a participating centre in the MRC funded PROMIS trial between 2013 and 2015 recruiting 130 patients. In response to perceived change prostate biopsy histological grading following introduction of pre-biopsy magnetic resonance imaging at our centre, we decided undertake retrospective analysis histology before after participation study. Methods: We identified 206 patients both 2012 2016 who had undergone biopsy. reviewed type performed (transrectal or...
Novel biomarkers for tumour burden and bone disease are required to guide clinical management of plasma cell dyscrasias. Recently, turnover markers (BTMs) Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) have been explored, although their role in the prospective assessment multiple myeloma (MM) monoclonal gammopathy undetermined significance (MGUS) is unclear. Here, we conducted a pilot observational cohort feasibility study combining serum BTMs DW-MRI addition standard assessment....
Abstract Androgen signaling is essential for the development of prostate cancer (PCa) initiated from prostatic basal cells with collocation androgen receptor gene mutations. Phytoestrogens, naturally occurring compounds are AR antagonist. These downregulate prostate-specific antigen (PSA) expression and cell proliferation. Thus, this gives a track to research these as possible treatment PCa. In work, STITCH molecular docking predict conformation ligands inside suitable target binding site....
Pharmacological treatment for BPH includes 5-α reductase inhibitors as Finasteride and Dutasteride a monotherapy or in combination with antimuscarinic drugs, alpha-blockers, 5-phosphodiesterase inhibitor drugs. Androgen receptor revealed several adverse events decreased libido, erectile dysfunction, ejaculatory gynecomastia. Hence, the emergence of complementary alternative medications having safety profile-preferably, edible natural products-would be highly desirable. In-silico studies...
An assessment of image quality is presented from a multicentre WB-MRI study. A radiologist assessed and the presence/severity several common artefacts/image issues metrics were also defined to measure these quantitatively. Image was consistently good or excellent, with only one DWI examination deemed non-diagnostic. In case most artefacts, quantitative measurements found correlate radiological statistically significant ordinal regression model predict DW score using measurements. These could...