A5029032791- Drug Solubulity and Delivery Systems
- Sesame and Sesamin Research
- Phytoestrogen effects and research
- RNA Interference and Gene Delivery
- Analytical Methods in Pharmaceuticals
- Synthesis and bioactivity of alkaloids
- Dendrimers and Hyperbranched Polymers
- Bioactive natural compounds
- Pharmacological Effects of Medicinal Plants
- Wound Healing and Treatments
- Neuropeptides and Animal Physiology
- Chemical Thermodynamics and Molecular Structure
- Pharmacological Receptor Mechanisms and Effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Phytochemicals and Medicinal Plants
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Advanced Chemical Sensor Technologies
- Cancer, Lipids, and Metabolism
- Antimicrobial agents and applications
- Breast Lesions and Carcinomas
- Protein Hydrolysis and Bioactive Peptides
- Advancements in Transdermal Drug Delivery
- Boron Compounds in Chemistry
Manipal Academy of Higher Education
2018-2022
Western Connecticut Health Network
2019
Danbury Hospital
2019
International Neuromodulation Society
2018
Birla Institute of Technology and Science, Pilani
2013
Pharmac
2013
NTL Institute for Applied Behavioral Science
2013
Narsee Monjee Institute of Management Studies
2010-2011
Terminalia tomentosa bark belongs to the family Combretaceae. The plant is astringent and useful in treatment of ulcers, vata, fractures, hemorrhages, bronchitis, diarrhea. Phytochemical investigation T. confirms presence flavonoids, polyphenols, tannins. has not been investigated for its anti-inflammatory antiarthritic activity. present study was undertaken explore possible Anti-inflammatory activity alcoholic aqueous extracts assessed by vivo methods. In potential evaluated Complete...
Abstract: Antioxidant potential of sesamol has led to being studied extensively in recent decades for its beneficial role vast aliments. There been a renewed interest this compound recently, due activities such as hepatoprotective, neuroprotective, chemopreventive, anti-inflammatory, cardioprotective, skin protective and antiaging properties which were established various preclinical models. Further studies may be required develop underlying mechanisms investigate biological an optimal dose...
Abstract Resveratrol obtained in grape seed and skin is structurally similar to a synthetic estrogen diethylstilbestrol. The endogenous estrogen, 17β-estradiol, induces cellular responses by binding the receptor alpha beta. bone fracture due decreased mineral density postmenopausal women linked reduced estrogen. adverse drug reactions of hormone replacement therapy warrant identifying unique natural compounds with ER-subtype specificity improve health. considered phytoestrogen; however, its...
The various Indian systems of medicine in addition to numerous local health traditions have been successful managing cancer across the globe using herbs. Keeping all this mind, present study has taken up, cytotoxic potential B.lanzan and A.lebbeck barks. objective is explore scientific basis both plant bark for its anti-carcinogenic utility. Different extracts plants were screened MTT assay technique, potent subjected HPTLC HPLC evaluate total phenolic flavonoid crude bark. In our study, we...
The aim of this study was to predict the in vivo plasma drug level milnacipran (MIL) from vitro dissolution data immediate release (IR 50 mg and IR 100 mg) matrix based controlled (CR formulations. Plasma concentrations these formulations were predicted by numerical convolution method. method uses derive levels using reported pharmacokinetic (PK) parameters a test product. bioavailability (Cmax AUC) found be 106.90 ng/mL, 1138.96 ng/mL h for 209.80 2280.61 which are similar those literature....
The objective of this study was to design oral controlled release (CR) matrix tablets Milnacipran using hydroxypropyl methylcellulose (HPMC) as the retardant polymer and effect various formulation factors such proportion, viscosity, compression force also pH dissolution medium on in-vitro drug. Two viscosity grade HPMC (15 K 100 K) were used in proportion 50, 100, 150 200 mg per CR tablet. In-vitro rate characterized model dependent approaches independent parameters [T50% T80% time, mean...
Background: Morphine tolerance on long-term usage leads to chronic pain conditions. Preclinical studies demonstrated that the upregulation of HDACs is associated with a decrease in sensitivity μ-opioid receptors, which results morphine tolerance. Objective: The present study was designed assess influence selected known HDAC inhibitors (NMJ2 and NMJ3) induced by administration Balb/c mice. Methods: In study, administered incremental doses 1, 2, 3.6, 6.5, 11.2, 21, 21 mg/kg daily for seven...
Milnacipran hydrochloride (MIL) is a selective serotonin and norepinephrine dual reuptake inhibitor used for the treatment of depression fibromyalgia. The aim present work was to carry out comparative pharmacokinetics evaluation in-house developed oral controlled release (CR) marketed immediate (IR) tablet formulation MIL. Three prototype CR formulations (i) MIL with HPMC 100K, single hydrophilic polymeric matrix [MSH], (ii) 100K sodium CMC, binary [MBH] (iii) hydrophobic wax tablets using...
• When two or more primary tumors arise at the same time, they are considered synchronous. A metachronous tumor in a new that develops after an initial cancer diagnosis. The diagnosis of vulvar breast is primarily histopathologic, based on morphology and immunostaining. Identifying as metastasis versus synchronous/metachronous significantly impacts staging treatment.
Abstract: Aim/Background: The anomalous production of dihydrotestosterone (DHT) observed in benign prostatic hyperplasia and prostate cancer particularly tissues the gland. primary male sex hormone, testosterone (T) is improved to a metabolite cells by 5a-reductase (5aR) type II enzyme through NADPH. A DHT which more potent than T. Drug therapy best alternative for treatment (BPH). act dropping formation inhibiting 5aR enzyme. Thus, this research work was undertaken design novel inhibitor...
Abstract Androgen signaling is essential for the development of prostate cancer (PCa) initiated from prostatic basal cells with collocation androgen receptor gene mutations. Phytoestrogens, naturally occurring compounds are AR antagonist. These downregulate prostate-specific antigen (PSA) expression and cell proliferation. Thus, this gives a track to research these as possible treatment PCa. In work, STITCH molecular docking predict conformation ligands inside suitable target binding site....
Pharmacological treatment for BPH includes 5-α reductase inhibitors as Finasteride and Dutasteride a monotherapy or in combination with antimuscarinic drugs, alpha-blockers, 5-phosphodiesterase inhibitor drugs. Androgen receptor revealed several adverse events decreased libido, erectile dysfunction, ejaculatory gynecomastia. Hence, the emergence of complementary alternative medications having safety profile-preferably, edible natural products-would be highly desirable. In-silico studies...