Lei Huang

ORCID: 0000-0001-9464-8577
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About
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Research Areas
  • Silk-based biomaterials and applications
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Synthesis and properties of polymers
  • Electrospun Nanofibers in Biomedical Applications
  • Advanced Polymer Synthesis and Characterization
  • Land Use and Ecosystem Services
  • Blood Coagulation and Thrombosis Mechanisms
  • Nanoparticle-Based Drug Delivery
  • Advanced Sensor and Energy Harvesting Materials
  • Concrete and Cement Materials Research
  • Dielectric materials and actuators
  • Magnesium Oxide Properties and Applications
  • Polymer Nanocomposites and Properties
  • Drilling and Well Engineering
  • Ginkgo biloba and Cashew Applications
  • Remote Sensing in Agriculture
  • Ferroelectric and Piezoelectric Materials
  • Vitamin K Research Studies
  • Conservation, Biodiversity, and Resource Management
  • Colorectal Cancer Treatments and Studies
  • Species Distribution and Climate Change
  • Microfluidic and Capillary Electrophoresis Applications
  • Lung Cancer Treatments and Mutations
  • Diabetes Treatment and Management
  • Gastrointestinal motility and disorders

Nanjing Drum Tower Hospital
2019-2025

Zhejiang A & F University
2024-2025

Fluor (United States)
2012-2024

The Affiliated Yongchuan Hospital of Chongqing Medical University
2024

Chongqing Medical University
2024

Central South University
2012-2023

Jimei University
2023

National University of Defense Technology
2023

China Medical University
2023

Nanchang University
2020-2022

Type I collagen-PEO fibers and non-woven fiber networks were produced by the electrospinning of a weak acid solution purified collagen at ambient temperature pressure. As determined high-resolution SEM TEM, morphology was influenced viscosity, conductivity, flow rate. Uniform with diameter range 100-150 nm from 2-wt% rate 100 μl min-1. Ultimate tensile strength elastic modulus resulting fabrics dependent upon chosen weight ratio blend. 1H NMR dipolar magnetization transfer analysis suggested...

10.1163/156856201753252516 article EN Journal of Biomaterials Science Polymer Edition 2001-01-01

Land Use and Cover Change (LUCC) has emerged as a primary driver of terrestrial carbon storage changes. However, the contributions LUCC to Above-Ground Carbon (AGC) in subtropical forests remain unclear due complex diverse trajectory. Quantitative assessment impact different trajectories on is essential for regional cycle mechanisms. Therefore, this study focuses Zhejiang Province, representative forest region China, accurately assess contribution AGC changes from 1984 2019. We first mapped...

10.1080/10095020.2024.2440615 article EN cc-by Geo-spatial Information Science 2025-01-10

Elastin-mimetic peptide polymers have been synthesized, and the morphological properties of fabricated small diameter fibers nonwoven fabrics characterized. An 81 kDa recombinant protein based upon repeating elastomeric sequence elastin (Val-Pro-Gly-Val-Gly)4(Val-Pro-Gly-Lys-Gly) was obtained through bacterial expression an oligomerized gene coding for tandem repeats monomer. The processed into by electrospinning technique morphology defined SEM TEM. choice processing parameters influenced...

10.1021/ma991858f article EN Macromolecules 2000-03-24

Rattle-type nanostructures with movable cores, porous shells, and hollow interiors have become attractive nanoplatforms in the field of nanomedicine, especially for targeted stimuli-responsive drug delivery. In this work, rattle-type gold nanorods@void@porous-SiO2 (GVPS) nanocomposites were fabricated facilely using surface-protecting etching method exhibited high photothermal conversion efficiency. Taking advantage shell interior, abundant space loading successfully improved capacity up to...

10.1021/acs.molpharmaceut.8b01298 article EN Molecular Pharmaceutics 2019-03-27

Context As a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in phase Ib clinical study for its ability to reduce postprandial blood glucose patients with type 2 diabetes mellitus (T2DM). However, the effects of on human plasma metabolomics are still unknown. Objective This aimed explore T2DM and potential metabolic regulatory mechanism involved. Study design In study, total 50 participants were enrolled randomly assigned 0.5 mg BID, 1 QD, QD dose groups, 4:1 random allocation...

10.3389/fendo.2025.1487058 article EN cc-by Frontiers in Endocrinology 2025-01-28

Abstract Collagen nanofibers were generated at ambient temperature and pressure by electrospinning a 1wt% solution of type I collagen polyethylene oxide. Products imaged with high‐resolution scanning electron microscopy (HRSEM) medium (∼30,000 ×) high magnifications (∼100,000 transmission (TEM). The capacity to produce may lead the generation extracellular matrix‐based fabrics applications in fields wound healing tissue engineering.

10.1002/sca.4950230603 article EN Scanning 2001-11-01

The formation mechanism of RSF alcogel was elucidated from morphological observations using TEM, AFM and confocal laser scanning microscopy (CLSM) as well the kinetic studies by Thioflavin T fluorescence rheological methods. An intriguing dual-structure—a nanofibrillar network on nanoscale a floc-like microscale—was observed within alcogel. Based our study, fractal dimension ramified fibrillar aggregate found to be 2.4–2.8 depending concentration. Meanwhile, through scaling analysis...

10.1039/b913510c article EN Soft Matter 2010-01-01

Introduction: TT-01025-CL is an oral, irreversible small molecule that potently inhibits vascular adhesion protein-1 (VAP-1) for the treatment of inflammation associated with non-alcoholic steatohepatitis (NASH). The objectives this study were to evaluate safety/tolerability, pharmacokinetics, and pharmacodynamics TT-01025-CL, a VAP-1 inhibitor, in healthy Chinese volunteers. Methods: Double-blind, placebo-controlled, dose-escalation studies conducted subjects randomized receive oral...

10.3389/fphar.2024.1327008 article EN cc-by Frontiers in Pharmacology 2024-04-29

Purpose: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR2285, first oral coagulation factor XIa (FXIa) inhibitor developed in China combination with aspirin, clopidogrel or ticagrelor healthy subjects. Methods: This study was a single-center, randomized, double-blind, placebo-controlled (only SHR2285) design (NCT04945616). A total 52 subjects, 29 male 23 female, were completed this study. The subjects divided into three groups: A, B C, 16 group [aspirin +...

10.3389/fphar.2022.1027627 article EN cc-by Frontiers in Pharmacology 2022-10-19

Abstract This article is focused on the analysis of Al-Li alloy powder’s thermal oxidation reactivity. The Scanning electron microscope (SEM) results show that particles are uniform and spherical. phase transformation powder during process was characterized by X-ray Diffraction (XRD), composition oxide mainly oxides such as LiAlO 2 LiAl 5 O 8 , indicating fully burned. Differential scanning calorimetry (DSC) thermogravimetric (TG) performed coupled with thermodynamic calculations. Li can...

10.1088/1742-6596/2478/3/032067 article EN Journal of Physics Conference Series 2023-06-01

The purpose of this study was to evaluate the effects sintering temperature and time on mineral composition high-alite white Portland cement clinker hydration activity clinker. Effects composition, C3S polymorph size heat release rate were analyzed by X-ray diffraction (XRD), scanning electron microscope (SEM), differential calorimetry&Thermogravimetric Analysis (DSC-TG) isothermal heat-conduction calorimetry. Results shown that, with increase (1450-1525 °C) (60-240 min), free lime (f-CaO)...

10.3390/ma13030494 article EN Materials 2020-01-21

Due to the advantages of a large filtration area, elongated filter cartridges are gradually replacing bags in dust collectors. However, production standards for these lack clarity determining various parameters. Therefore, this paper combines experimental validation with computational fluid dynamics simulations analyze resistance characteristics cartridges, aiming establish recommended parameter combinations their optimal design. Single factor analysis and Response Surface Methodology (RSM)...

10.1016/j.enbenv.2024.03.008 article EN cc-by-nc-nd Energy and Built Environment 2024-04-01

Vegetation phenology refers to the cyclical changes of plant development in different seasons year, and is result interaction between environmental factors biological internal regulatory mechanisms. Current large-scale studies mainly use vegetation indices for remote sensing retrieval, while greenness information subtropical forests inconspicuous, causing regular retrieve their ineffectively. SIF (Solar-induced chlorophyll fluorescence) strongly coupled with GPP (Gross Primary Productivity),...

10.1016/j.agrformet.2024.110182 article EN cc-by-nc-nd Agricultural and Forest Meteorology 2024-08-07

Camellia osmantha is a new species of the genus and an economically important ornamental plant. Its activity ingredients are less studied than other plants. This study investigated antithrombotic effect chemical components C. fruit cores using platelet aggregation assays coagulation function tests. The fruits were extracted with ethanol to obtain crude extract. extract was dissolved in water further eluted different concentrations methanol on MCI resin column three fractions. These samples...

10.1002/fsn3.2769 article EN Food Science & Nutrition 2022-03-21
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