A5055396535- Listeria monocytogenes in Food Safety
- Microbial Inactivation Methods
- Essential Oils and Antimicrobial Activity
- Salmonella and Campylobacter epidemiology
- Microbial Metabolic Engineering and Bioproduction
- African history and culture studies
- Christian Theology and Mission
- CRISPR and Genetic Engineering
- Religion, Society, and Development
- Bacteriophages and microbial interactions
- Clinical Laboratory Practices and Quality Control
- Global Maritime and Colonial Histories
- Bacterial Genetics and Biotechnology
- Antibiotic Use and Resistance
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Biofuel production and bioconversion
- Multiculturalism, Politics, Migration, Gender
- Complementary and Alternative Medicine Studies
- Contemporary Christian Leadership and Education
- Parasitic Infections and Diagnostics
- Colonialism, slavery, and trade
- Bacterial Identification and Susceptibility Testing
- History of Colonial Brazil
- Probiotics and Fermented Foods
Technical University of Denmark
2022-2025
University of Southern Denmark
2017-2025
Fundação de Apoio à Universidade Federal de São Paulo
2010-2021
Universidade Federal de São Paulo
2012-2020
Universidade Sénior Contemporânea
2020
Universidade do Porto
2020
National Council for Scientific and Technological Development
2020
Union des Industries Ferroviaires Européennes
2020
Abbott (Sweden)
2020
Ordem dos Médicos
2020
The Gram-positive bacterium Listeria monocytogenes is a highly adaptable pathogen capable of causing severe foodborne infections, particularly in vulnerable populations. During infection, L. uses variety virulence factors to invade and multiply within host cells. transcriptional regulator PrfA controls the expression these essential for intracellular lifestyle . Long-chain unsaturated free fatty acids (FFAs) have long been recognized their antimicrobial activity were recently shown inhibit...
External quality assurance (EQA) is an objective tool to assess laboratories' diagnostic performance and their adherence recognized international standards. Quality Assessment in Asia (EQASIA) EQA network South South-East established 2020 with the aim of improving bacteriology diagnostics across all One Health sectors region. The this paper provide a comprehensive overview results collected from EQASIA improvements among participating laboratories. Six rounds were conducted between 2021...
The facultative intracellular pathogen Listeria monocytogenes can persist and grow in a diverse range of environmental conditions, both outside within its mammalian host. alternative sigma factor Sigma B (σB) plays an important role this adaptability is critical for the transition into While some functions σB regulon facilitating are understood σB-dependent small regulatory RNAs (sRNAs) remain poorly characterized. In study, we focused on elucidating function Rli47, sRNA that highly induced...
The LhrC family of small regulatory RNAs (sRNAs) is known to be induced when the foodborne pathogen Listeria monocytogenes exposed infection-relevant conditions, such as human blood. Here we demonstrate that excess heme, core component hemoglobin in blood, leads a strong induction members LhrC1-5. heme-dependent activation lhrC1-5 relies on response regulator LisR, which play role virulence and stress tolerance. Importantly, our studies revealed LhrC1-5 LisR contribute adaptation L. heme....
Naturally occurring free fatty acids (FFAs) are recognized as potent antimicrobial agents that also affect the production of virulence factors in bacterial pathogens. In foodborne pathogen Listeria monocytogenes, some medium- and long-chain FFAs act well signaling compounds, causing a repression transcription genes. We previously observed master regulator PrfA is involved both virulence-inhibitory response L. monocytogenes to selected FFAs, but underlying mechanisms presently unknown. Here,...
The bacterial pathogen Listeria monocytogenes encodes seven homologous small regulatory RNAs, named the LhrC family of sRNAs. LhrCs are highly induced under infection-relevant conditions and known to inhibit expression multiple target mRNAs encoding virulence-associated surface proteins. In all cases studied so far, use their CU-rich regions for base pairing complementary AG-rich sequences ribosomal binding site (RBS) specific mRNAs. Consequently, LhrC-mRNA interaction results in inhibition...
For pathogenic bacteria, host-derived heme represents an important metabolic cofactor and a source for iron. However, high levels of are toxic to bacteria. We have previously shown that excess has growth-inhibitory effect on the Gram-positive foodborne pathogen Listeria monocytogenes, we learned LhrC1-5 family small RNAs, together with two-component system (TCS) LisRK, play role in adaptation L. monocytogenes stress conditions. broader knowledge how this responds toxicity is still lacking....
Free fatty acids (FFAs) are known to exhibit antimicrobial and anti-virulent properties against bacterial pathogens. Specific FFAs, such as lauric acid (LA; C12:0), exert both effects the foodborne pathogen Listeria monocytogenes: at low levels, LA acts inhibit activity of virulence regulator PrfA, whereas higher inhibits growth. Deletion prfA is promote tolerance toward suggesting that response L. monocytogenes FFAs could be linked. In this study, we explored holding an anti-virulence by...
All organisms contain RNA modifications in their ribosomal (rRNA), but the importance, positions and exact function of these are still not fully elucidated. Various functions such as stabilizing structures, controlling ribosome assembly facilitating interactions have been suggested some cases substantiated. Bacterial rRNA contains much fewer than eukaryotic rRNA. The modification patterns bacteria differ from each other, too few mapped to draw general conclusions. This study maps 23S...
ABSTRACT Listeria monocytogenes is a food-borne pathogen responsible for the disease listeriosis. It ubiquitously found in environment and soil one of its natural habitats. highly capable coping with various stressful conditions. We hypothesized that stress-responsive two-component systems such as LisRK might contribute to adaptation L. environment. Indeed, investigations population dynamics wild-type mutant strains suggest an important role optimal fitness sterile soil. Results from...
Abstract Background Strengthening external quality assessment (EQA) services across the One Health sector supports implementation of effective antimicrobial resistance (AMR) control strategies. Here we describe and compare 2 different approaches for conducting virtual laboratory follow-up assessments within an EQA program to evaluate management system (QMS) procedures pathogen identification susceptibility testing (AST). Methods During coronavirus disease 2019 (COVID-19) pandemic in 2021...
Free fatty acids (FFAs) have strong antimicrobial properties against pathogenic bacteria and are known as natural protective agents bacterial infections. Growth of the foodborne pathogen Listeria monocytogenes is highly affected by presence FFAs, however, response L. toward FFAs not fully understood. Here, we explore how gains tolerance present a novel mechanism conferring protection FFA toxicity. Strains tolerant palmitoleic acid were isolated whole genome sequenced, mutations found in...
O artigo consiste no estudo da trajetória constituição das escolas coloniais território que corresponde, atualmente, aos países do Sudão e Sul (decretado autônomo ano de 2011). ensino colonial desenvolvido pelas missões católicas foi fundamental para hierarquizaçãode populações a consagração divisão política territorialdos povos sudaneses. processo escolar também desenvolveu formação quadros elite produziu conteúdos históricos escolares circularam além fronteiras coloniais, foram ensinados...
During the contestation processes against colonialisms, in second part of twentieth century, studies departments and centers emerging countries known Third World were pivotal importance to build networks scientific, economic political solidarity. Among these institutions, it stands out Department African Studies Delhi University. In following interview planned by Center History on Contemporary Africa (Nucleo de Historia sobre Contemporânea - NHAC) UNIFESP, Suresh Kumar, current director...
Este dossiê propõe-se problematizar a emergência do princípio da “Promoção Humana”, que se origina nos anos 60 século XX com orientação das missões AD GENTES (para todos os povos e culturas), como uma resposta à crítica ao colonialismo na África Ásia envolvimento Igrejas cristãs esse processo. A Humana” seria tradução cristã ideia de autodeterminação dos propiciou importantes diálogos no campo religioso sobre o fim tutela colonial favorecimento reivindicações singularidades não brancos eram cristãos.
Entrevista concedida em 14 de abril 2018 pelo Professor Dr. Silvio Almeida Carvalho Filho (Professor História da África na Universidade Federal do Rio Janeiro e Estado Janeiro, Presidente Associação Estudos Africanos, entre 2016 2018) 2018.