A5079401712- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Total Knee Arthroplasty Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Poverty, Education, and Child Welfare
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Muscle Physiology and Disorders
- Lower Extremity Biomechanics and Pathologies
- Cholinesterase and Neurodegenerative Diseases
- Microfluidic and Bio-sensing Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hernia repair and management
- African studies and sociopolitical issues
- Bone fractures and treatments
- Manufacturing Process and Optimization
- Mesenchymal stem cell research
- Child Nutrition and Water Access
- Connective tissue disorders research
- Intestinal and Peritoneal Adhesions
- Periodontal Regeneration and Treatments
- Carbon Nanotubes in Composites
Sanofi (Mexico)
2024
Manufacturing Institute
2022
Cornell University
2016-2019
Worcester Polytechnic Institute
2012
Carnegie Mellon University
2012
Abstract Background Bone marrow mesenchymal stem cells (MSCs) have shown positive therapeutic effects for meniscus regeneration and repair. Preliminary in vitro work has indicated results MSC applications tissue engineering; however, more information is needed on how to direct behavior. The objective of this study was examine the effect co-culture with primary meniscal fibrochondrocytes (FCCs) a three-dimensional collagen scaffold fibrochondrogenic media. Co-culture MSCs FCCs hypothesized...
Mesenchymal stem cells (MSCs) have been investigated with promising results for meniscus healing and tissue engineering. While MSCs are known to contribute extracellular matrix (ECM) production, less is about how produce align large organized fibers application engineering the meniscus. The goal of this study was investigate capability organize ECM molecules compared meniscal fibrochondrocytes (FCCs). Bovine FCCs were encapsulated in an anatomically accurate collagen using monoculture...
Single-wall carbon nanotubes (SWCNTs) have been dispersed with proteins to increase biocompatibility and specificity, but examinations of dispersion parameters on functional cellular uptake are required for utilization SWCNTs in biological applications. Here we correlate conditions SWCNT various these NIH-3T3 fibroblasts J774A.1 macrophage-like cells. We varied protein types (bovine serum albumin – BSA, lysozyme LSZ, γ-globulins γG), : ratio sonication time. Each created stable, high yield...
Abstract Tissue‐engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation the native bone. The insertion meniscus into bone is critical for meniscal function and inclusion soft tissue‐to‐bone interface in tissue engineered implant can aid process. characterized by gradients composition, architecture, cellular phenotype, which are all difficult replicate. In this study, with gradient fibrochondrocytes mesenchymal stem cells subjected...
Materials engineering can generally be divided into "bottom-up" and "top-down" approaches, where current state-of-the-art methodologies are bottom-up, relying on the advent of atomic-scale technologies. Applying bottom-up approaches to biological tissues is challenging due inherent complexity these systems. Top-down provide many advantages over for tissues, given that some already built system. Here, we generate interfacial scaffolds by spatially controlled removal mineral content from...
Abstract Analysis of real-world data (RWD) is attractive for its applicability to scenarios but RWD typically used drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neuroinflammatory diseases with relatively patients such as amyotrophic lateral sclerosis (ALS), which characterized by progressive muscle weakness death no disease-modifying treatments available. We previously reclassified drugs their simulated effects on proteins...
The goal of this project is to create an accurate model for skeletal muscle in vitro, with a specific focus enable mechanical stimulation the tissue. began by creating list functions, objectives, and constraints based upon client needs statement. Conceptual designs were then brainstormed tested feasibility order select components final design. design currently assembly testing phases including tissue formation.
In article number 1800806 by Lawrence J. Bonassar and co-workers, a tissue engineered meniscal insertion is generated using compositional, cellular, chemical gradients. Constructs are subjected to mechanical conditioning through custom bioreactor. Utilization of cellular gradients results in constructs with localized interfacial structuring, collagen fiber development, improved performance respect controls.