A5021996888- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Knee injuries and reconstruction techniques
- Conducting polymers and applications
- Tendon Structure and Treatment
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Muscle activation and electromyography studies
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Music Therapy and Health
- Infrared Thermography in Medicine
- Tactile and Sensory Interactions
- Nerve Injury and Rehabilitation
- Healthcare Technology and Patient Monitoring
- Problem and Project Based Learning
- Mechatronics Education and Applications
- Connective tissue disorders research
- Advanced Memory and Neural Computing
- Gastrointestinal motility and disorders
- Anatomy and Medical Technology
- Hearing Loss and Rehabilitation
- Embodied and Extended Cognition
University of Cambridge
2020-2025
Dartmouth College
2024-2025
University of Central Lancashire
2023
Cornell University
2017-2021
Hollister (United States)
2021
Addressing the mechanical mismatch between biological tissue and traditional electronic materials remains a major challenge in bioelectronics. While rigidity of such limits biocompatibility, supramolecular polymer networks can harmoniously interface with tissues as they are soft, wet, stretchable. Here, an electrically conductive network that simultaneously exhibits both ionic conductivity while maintaining tissue-mimetic properties, providing ideal human body, is introduced. Rational design...
Abstract Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long‐term interfaces between electronics body remains a challenge. Implantation of bioelectronic device typically initiates foreign response, which can limit recording stimulation efficacy. Techniques from regenerative medicine have shown high propensity promoting integration implants with surrounding tissue, but these lack capabilities sophisticated actuation afforded by electronics....
Implantable devices interfacing with peripheral nerves exhibit limited longevity and resolution. Poor nerve-electrode interface quality, invasive surgical placement development of foreign body reaction combine to limit research clinical application these devices. Here, we develop cuff implants a conformable design that achieve high-quality stable in chronic implantation scenarios. When implanted sensorimotor the arm awake rats for 21 days, record nerve action potentials fascicle-specific...
Fabricating flexible bioelectronics remains an ongoing challenge in pursuing a cost-effective, efficient, scalable, and environmentally friendly approach for research commercial applications. The current dominant method, lithography, presents challenges due to its incompatibility with solvent-sensitive biomaterials the phase mismatch between photoresist substrates, such as elastomers. This study proposes simplified, cleanroom-free toolkit potential alternative lithography fabricating...
Recently, the scientific community has shown considerable interest in engineering tissues with organized compositional and structural gradients to mimic hard-to-soft tissue interfaces. This effort is hindered by an incomplete understanding of construction native In this work, we combined Raman microscopy confocal elastography map compositional, structural, mechanical features across stiff-to-compliant interface attachments meniscus knee. study provides new insight into methods which biology...
3D cell models have made strides in the past decades response to failures of 2D cultures translate targets during drug discovery process. Here, we report on a novel multiwell plate bioelectronic platform, namely, e-transmembrane, capable supporting and monitoring complex architectures. Scaffolds PEDOT:PSS [poly(3,4-ethylenedioxythiophene):polystyrene sulfonate] are microengineered function as separating membranes for compartmentalized cultures, well electronic components real-time situ...
Abstract Tissue‐engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation the native bone. The insertion meniscus into bone is critical for meniscal function and inclusion soft tissue‐to‐bone interface in tissue engineered implant can aid process. characterized by gradients composition, architecture, cellular phenotype, which are all difficult replicate. In this study, with gradient fibrochondrocytes mesenchymal stem cells subjected...
Articular cartilage is a collagen-rich tissue that provides smooth, lubricated surface for joints and also responsible load bearing during movements. The major components of are water, collagen, proteoglycans. Osteoarthritis degenerative disease articular cartilage, in which an early-stage indicator the loss proteoglycans from collagen matrix. In this study, confocal Raman microspectroscopy was applied to study degradation specifically focused on spatially mapping glycosaminoglycans (GAGs)....
Abstract The enteric nervous system represents a primary point of contact for host factors that influence bodily health and behavior. This division the autonomic is unique in both its extensivity, with neurons distributed throughout gastrointestinal tract from esophagus to rectum, capability local information processing. Here, we show construction validation bioelectronic device access neural produced processed tract. We designed an implant concurrent surgical procedure place recording...
Materials engineering can generally be divided into "bottom-up" and "top-down" approaches, where current state-of-the-art methodologies are bottom-up, relying on the advent of atomic-scale technologies. Applying bottom-up approaches to biological tissues is challenging due inherent complexity these systems. Top-down provide many advantages over for tissues, given that some already built system. Here, we generate interfacial scaffolds by spatially controlled removal mineral content from...
Abstract Implantable devices interfacing with peripheral nerves exhibit limited longevity and resolution. Poor nerve-electrode interface quality, invasive surgical placement development of foreign body reaction combine to limit research clinical application these devices. Here, we develop cuff implants an ultraconformable design that achieve high-quality stable in chronic implantation scenarios. When implanted sensorimotor the arm awake rats for 21 days, recorded nerve action potentials...
Cochlear implants are a life-changing technology for those with severe sensorineural hearing loss, partially restoring through direct electrical stimulation of the auditory nerve. However, they known to elicit an immune response resulting in fibrotic tissue formation cochlea that is linked residual loss and suboptimal outcomes. Intracochlear fibrosis difficult track without postmortem histology, no specific marker exists. In this study, tissue-engineered model cochlear developed following...
Recapitulating the collagen fiber structure of native menisci is one major challenges in development tissue-engineered menisci. Native fibers are developed by complex interplay biochemical and biomechanical signals. In this study, we optimized glucose transforming growth factor-β1 (TGF-β1) concentrations combination with mechanical anchoring to balance contributions proteoglycan synthesis contractile behavior assembly. Glucose had a profound effect on final dimensions collagen-based...
Cellular contraction is a universal phenomenon that drives various processes in the body. As such, measurement of cell contractility great interest to scientific community. However, contracting cells apply very small stresses, which can be difficult monitor. Various techniques have been developed overcome these issues, with resolutions extending single level. Despite significant progress this field, many limitations remain, including ability measure instantaneously and vivo. Bioelectronics...
Bioelectronics offer unprecedented spatiotemporal resolution in medicine, opening new doors to electronic therapies and monitoring systems. However, the development of bioelectronic medicine requires construction a stable interface between device tissue. Here, we focus on generating framework from which view this interface, specifically for case implants. We discuss general criteria that are important consider when constructing implant, with major structure as it pertains categorize...
Digestion is a fundamentally important process for an individual's life. However, the physical of digestion hidden inside body, making it challenging to understand and particularly difficult topic students learn in classroom. Traditional approaches teaching body processes include mixture textbook visual learning. not visual. This activity designed engage using combination visual, inquiry-based, experiential learning introduces scientific method secondary school. The laboratory simulates...
Abstract Since Dr. Theodor Schwann posed the extension of Cell Theory to mammals in 1839, scientists have dreamt up ways interface with and influence cells. Recently, considerable ground this area is gained, particularly scope bioelectronics. New advances provided a means record electrical activity from cells, examining neural firing or epithelial barrier integrity, stimulate cells through applied fields. Many these applications utilize invasive implantation systems perform interaction close...
Peripheral nerve neurotechnologies hold significant promise as avenues for new closed-loop clinical treatments. However, analysis tools recordings - a key component of technologies remain underdeveloped compared to brain-focused methods. This study introduces and explores the performance two novel signal techniques which rely on defining feature peripheral signals: reliable conduction velocity signals transmitted by axons in nerves. We test capabilities introduced cross-correlation spike...
Elementary and middle school science curricula typically focus on generating an interest in engineering through the use of hands-on activities that demonstrate specific concepts. Laboratory designed this manner often circumvent some main challenges engineers scientists face, namely balancing advantages disadvantages for a variety potential solutions to solve problem. This activity was show students different given problem can exist, must manage priorities when choosing best solution....