A5059058382- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Hearing, Cochlea, Tinnitus, Genetics
- 3D Printing in Biomedical Research
- Ear Surgery and Otitis Media
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Blood properties and coagulation
- Cellular Mechanics and Interactions
- Surgical Sutures and Adhesives
- Hearing Impairment and Communication
- Ultrasonics and Acoustic Wave Propagation
- Education Systems and Policy
- Enzyme Catalysis and Immobilization
- Construction Project Management and Performance
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neural Engineering
- Public-Private Partnership Projects
- CAR-T cell therapy research
- E-commerce and Technology Innovations
- Protein Hydrolysis and Bioactive Peptides
- Additive Manufacturing and 3D Printing Technologies
- RNA Interference and Gene Delivery
University of Cambridge
2020-2023
University of Manchester
2018-2023
Stevenage Bioscience Catalyst
2019-2022
Biochemical Society
2012
University College London
2012
Polycaprolactone (PCL) scaffolds have been widely investigated for tissue engineering applications, however, they exhibit poor cell adhesion and mechanical properties. Subsequently, PCL composites produced to improve the material This study utilises a natural material, Bombyx mori silk microparticles (SMP) prepared by milling fibre, produce composite enhance Silk is biocompatible biodegradable with excellent However, there are no studies using SMPs as reinforcing agent in 3D printed...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Goal:</i> Advances in computational models of biological systems and artificial neural networks enable rapid virtual prototyping neuroprostheses, accelerating innovation the field. Here, we present an end-to-end model for predicting speech perception with cochlear implants (CI), most widely-used neuroprosthesis. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> The integrates CI signal...
Abstract Viral vectors such as adenovirus have successful applications in vaccines and gene therapy but the manufacture of high‐quality virus remains a challenge. It is desirable to use adsorption‐based chromatographic separations that so effectively underpin therapeutic protein manufacture. However fundamental differences size stability this class product mean it necessary revisit design sorbent's morphology surface chemistry. In study, behaviour cellulose nanofiber ion‐exchange sorbent...
Cochlear implants use electrical stimulation of the auditory nerve to restore sensation hearing deaf people. Unfortunately, current spreads extensively within cochlea, resulting in "blurring" signal, and that is far from normal. Current spread can be indirectly measured using implant electrodes for both stimulating sensing, but this provides incomplete information near electrode due electrode-electrolyte interface effects. Here, we present a 3D-printed "unwrapped" physical cochlea model with...
(1) Background: During a cochlear implant insertion, the mechanical trauma can cause residual hearing loss in up to half of implantations. The forces on cochlea during insertion lead this but be highly variable between subjects which is thought due differing anatomy, namely scala tympani. This study presents systematic investigation influence different geometrical parameters tympani force. these were determined by testing within 3D-printed, optically transparent models with geometric...
Cochlear implants are a life-changing technology for those with severe sensorineural hearing loss, partially restoring through direct electrical stimulation of the auditory nerve. However, they known to elicit an immune response resulting in fibrotic tissue formation cochlea that is linked residual loss and suboptimal outcomes. Intracochlear fibrosis difficult track without postmortem histology, no specific marker exists. In this study, tissue-engineered model cochlear developed following...
This paper is about the effects of reactive oxygen species (ROS) - and their nanoparticle-mediated extracellular removal in TGF-β1-induced differentiation fibroblasts (human dermal HDFa) to more contractile myofibroblasts, maintenance this phenotype. Here, poly(propylene sulfide) (PPS) nanoparticles have been employed on 2D 3D vitro models, showing extremely low toxicity undergoing negligible internalization, thereby ensuring an extracellular-only action. Firstly, PPS abrogated ROS-mediated...
The invasion of a matrix by migrating cells is key step in its remodelling. At least 2D migration models, tend to localize stiffer areas (durotaxis). Here, we show that mechanical properties affect differently the 3D rate: non-proteolytic cell facilitated softer matrices. In these gels, modulus was varied introducing defects fibres, leaving largely intact nanostructure. matrices derive from fibrin via functionalization with bioinert polymer [poly(ethylene glycol), PEG] through an affinity...
To investigate the value of scalp surface potentials to identify and manage partial short circuits ground in cochlear implant electrodes.A retrospective review patients with suspected circuits.Electrical output individual electrodes was measured using for reporting a change hearing function. Electrical compared functional performance impedance measurements determine if devices were experiencing decrease as result reduced electrical output. checked an artificial cochlea two implants following...
Abstract The cochlea is one of the most complex organs in human body, exhibiting a interplay characteristics acoustic, mechanical, electrical, and biological functions. Functional models are an essential platform for studying hearing mechanics crucial developing next-generation auditory prostheses artificial systems sensorineural restoration. Recent advances additive manufacturing, organ-on-a-chip models, drug delivery platforms, intelligence have provided valuable insights into how to...
An engineered mouse embryonic stem cell model with survivin as a molecular marker
Abstract Cold marine environments are abundant on earth and represent a rich resource for low temperature enzymes. Here we apply in silico bioprospecting methods followed by vitro expression biochemical analyses to characterise novel lipase from the Antarctic tunicate Salpa thompsoni . A 586 amino acid pancreatic lipase-like gene was identified S. transcriptomic data, expressed as hexahistadine fusion protein Escherichia coli at 10°C purified affinity chromatography. Hydrolysis of synthetic...