Leslie D. Knecht

ORCID: 0000-0001-9504-1769
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About
Contact & Profiles
Research Areas
  • bioluminescence and chemiluminescence research
  • 3D Printing in Biomedical Research
  • Bacterial Genetics and Biotechnology
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Infant Health and Development
  • Micro and Nano Robotics
  • Gut microbiota and health
  • Advanced biosensing and bioanalysis techniques
  • Mycorrhizal Fungi and Plant Interactions
  • Bacillus and Francisella bacterial research
  • Plant Parasitism and Resistance
  • Clostridium difficile and Clostridium perfringens research
  • Problem and Project Based Learning
  • Various Chemistry Research Topics
  • Cell Image Analysis Techniques
  • Bacterial biofilms and quorum sensing
  • Electrohydrodynamics and Fluid Dynamics
  • Advanced Biosensing Techniques and Applications
  • Cancer Research and Treatments
  • Innovative Teaching Methods
  • Vagus Nerve Stimulation Research
  • Allelopathy and phytotoxic interactions
  • Biosensors and Analytical Detection

University of Miami
2012-2023

University of Kentucky
2011

Bacteria in humans play an important role health and disease. Considerable emphasis has been placed understanding the of bacteria host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood brain motility gut, can also act as a bacterial signaling molecule pathogenic bacteria. Specifically, found serotonin acts via quorum sensing it stimulates production virulence factors increases biofilm formation vitro vivo novel mouse infection model. This discovery...

10.1016/j.ebiom.2016.05.037 article EN cc-by-nc-nd EBioMedicine 2016-05-29

Nanomaterials have found numerous applications as tunable, remotely controlled platforms for drug delivery, hyperthermia cancer treatment, and various other biomedical applications. The basis the interest lies in their unique properties achieved at nanoscale that can be accessed via remote stimuli. These could then exploited to simultaneously activate secondary systems are not actuatable. In this work, iron oxide nanoparticles encapsulated a bisacrylamide cross-linked polyacrylamide hydrogel...

10.1021/nn303308v article EN ACS Nano 2012-09-18

Allelopathy is a common and important stressor that shapes plant communities can alter soil microbiomes, yet little known about the direct effects of allelochemical addition on bacterial fungal or potential for allelochemical-selected microbiomes to mediate performance responses, especially in habitats naturally structured by allelopathy. Here, we present first community-wide investigation microbial mediation testing how allelopathy affects microbiome structure these changes impact...

10.1111/nph.19249 article EN cc-by-nc New Phytologist 2023-09-22

Herein, we describe our experience transitioning two multi-instructor, multisection courses in both general and organic chemistry online during the COVID-19 pandemic from face-to-face instruction methods to an content delivery format. Beyond challenges of common assessments, also had coordinate discussion sections hosted by teaching assistants workshops undergraduate peer facilitators. We discuss difference attendance assessments before after transition learning. Additionally, different uses...

10.1021/acs.jchemed.0c00670 article EN Journal of Chemical Education 2020-08-06

Many microbial phenotypes are differentially or exclusively expressed on agar surfaces, including biofilms, motility, and sociality. However, agar-based assays limited by their low throughput, which increases costs, lab waste, space requirements, the time required to conduct experiments. Here, we demonstrate use of wax-printed microfluidic paper-based analytical devices (μPADs) measure linear growth rate microbes an media as a means circumventing aforementioned limitations. The main...

10.1371/journal.pone.0225020 article EN cc-by PLoS ONE 2020-10-08

Arsenic poses a major threat to both human populations and the environment. It is carcinogenic potent toxin. Because of its hydrophilicity, dangerous levels arsenic can be found in drinking water many communities, especially areas where collected from wells. As such, developing methods quickly reliably assess wide variety matrices for presence very important. The current gold standard detection inductively‐coupled plasma‐mass spectrometry (ICP‐MS). Due limitations ICP‐MS, chiefly expense...

10.1096/fasebj.31.1_supplement.lb125 article EN The FASEB Journal 2017-04-01
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