A5030633258- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Autism Spectrum Disorder Research
- Enterobacteriaceae and Cronobacter Research
- Gut microbiota and health
- Escherichia coli research studies
- Infant Nutrition and Health
- Bacterial biofilms and quorum sensing
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Genetics and Neurodevelopmental Disorders
- Bacterial Infections and Vaccines
- Sinusitis and nasal conditions
- Neuroscience and Neural Engineering
- Meningioma and schwannoma management
- Biochemical Analysis and Sensing Techniques
- Antimicrobial Peptides and Activities
- RNA regulation and disease
- Vibrio bacteria research studies
- Retinal Development and Disorders
- Family and Disability Support Research
- Diet and metabolism studies
- Diabetes and associated disorders
University of Miami
2016-2025
Rutgers, The State University of New Jersey
2024-2025
Cochlear (United States)
2020-2024
Cochlear (Australia)
2021-2022
Florida International University
2020-2021
Henan Provincial People's Hospital
2018
Zhengzhou University
2018
Neurological Surgery
2018
Rajasthan Technical University
2015
Children's Hospital of Los Angeles
2008-2012
While the infection rate of coronavirus disease 2019 (COVID-19) rises exponentially around globe, individuals with autism spectrum disorder are being identified as part a group at higher risk for complications from COVID-19.1Chow N Fleming-Dutra K Gierke R et al.Preliminary estimates prevalence selected underlying health conditions among patients Coronavirus 2019—United States, February 12–March 28, 2020.MMWR Morb Mortal Wkly Rep. 2020; 69: 382-386Crossref PubMed Google Scholar Furthermore,...
Bacteria in humans play an important role health and disease. Considerable emphasis has been placed understanding the of bacteria host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood brain motility gut, can also act as a bacterial signaling molecule pathogenic bacteria. Specifically, found serotonin acts via quorum sensing it stimulates production virulence factors increases biofilm formation vitro vivo novel mouse infection model. This discovery...
Hearing loss is the most common sensory deficit in humans. We show that a point mutation DCDC2 (DCDC2a), member of doublecortin domain-containing protein superfamily, causes non-syndromic recessive deafness DFNB66 Tunisian family. Using immunofluorescence on rat inner ear neuroepithelia, DCDC2a was found to localize kinocilia hair cells and primary cilia nonsensory supporting cells. fluorescence distributed along length kinocilium with increased density toward tip. DCDC2a-GFP overexpression...
OPINION article Front. Cell. Neurosci., 27 March 2018Sec. Cellular Neuropathology Volume 12 - 2018 | https://doi.org/10.3389/fncel.2018.00078
During hematogenously disseminated disease, Candida albicans infects most organs, including the brain. We discovered that a C. vps51Δ/Δ mutant had significantly increased tropism for brain in mouse model of disease. To investigate mechanisms this enhanced trafficking to brain, we studied interactions wild-type and with microvascular endothelial cells vitro. These studies revealed invasion is mediated by fungal invasins, Als3 Ssa1. binds gp96 heat shock protein, which expressed on surface...
Significance Concerted action of thousands proteins is required for the inner ear to convert acoustic waves into electrical signals hearing. Many these are currently unknown. This study uses a genetic approach identify FAM65B as gene mutated in family with sensorineural hearing loss. Characterization shows that it component plasma membrane stereocilia hair bundle, essential organelle which originate ear. Thus, previously unrecognized crucial
Type 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities. However, the precise trigger autoimmunity disease onset remain incompletely elucidated. This integrative perspective article synthesizes cumulative role gene-environment interaction in pathophysiology T1D. Genetics plays T1D susceptibility, particularly at major histocompatibility (MHC) locus cathepsin H (CTSH) locus. In addition...