A5002475633- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Laser-induced spectroscopy and plasma
- Radiation Dose and Imaging
- Nuclear reactor physics and engineering
- Hemodynamic Monitoring and Therapy
- Radiopharmaceutical Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Orthopaedic implants and arthroplasty
- Head and Neck Cancer Studies
- Laser-Plasma Interactions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Electron and X-Ray Spectroscopy Techniques
- Radiation Detection and Scintillator Technologies
- High-pressure geophysics and materials
- Cardiovascular and exercise physiology
McGill University
2016-2024
Jewish General Hospital
2024
Université de Montréal
2022
Centre Hospitalier de l’Université de Montréal
2022
McGill University Health Centre
2019
Abstract Laser-driven particle acceleration, obtained by irradiation of a solid target using an ultra-intense ( I > 10 18 W/cm 2 ) short-pulse (duration <1 ps) laser, is growing field interest, in particular for its manifold potential applications different domains. Here, we provide experimental evidence that laser-generated particles, protons, can be used stress testing materials and are particularly suited identifying to harsh conditions. We show these protons produce, very short...
Despite being considered the gold standard for brachytherapy dosimetry, Monte Carlo (MC) has yet to be implemented into a software treatment planning. The purpose of this work is present RapidBrachyMCTPS, novel planning system (TPS) applications equipped with graphical user interface (GUI), optimization tools and Geant4-based MC dose calculation engine, RapidBrachyMC. Brachytherapy sources applicators were in RapidBrachyMC made available via source applicator library GUI. To benchmark...
The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. Tracks monoenergetic with kinetic energies ranging from 100 eV 1 MeV were in an infinite spherical water phantom Geant4-DNA extension included Geant4 toolkit version 10.2 (patch 02). obtained through random sampling transfer points and overlaying scoring volumes within associated volume tracks. Relative frequency deposition f(>E)/f(>0)...
Purpose Intensity modulated brachytherapy (IMBT) is a novel high dose rate (HDR BT) technique which incorporates static or dynamic shielding to increase tumor coverage and/or spare healthy tissues. The purpose of this study present delivery system (AIM‐Brachy) design that can enable dynamic‐shield IMBT for prostate cancer. Methods AIM‐Brachy dynamically controls the rotation platinum shields, placed within interstitial catheters, partially collimate radiation emitted from an 169 Yb source....
To analyze mechanical adaptations that must occur in the cardiovascular system to reach high cardiac outputs known at peak aerobic performance, we adapted a computational model of circulation by adding second parallel venous compartment as proposed August Krogh 1912. One has large compliance and slow time constant emptying; it is representative splanchnic circulation. The other low fast emptying muscle beds. Fractional distribution between two compartments an important determinant output....
This study compares conventional
Purpose A prototype Yb source was developed in combination with a dynamic rotating platinum shield system (AIM‐Brachy) to deliver intensity modulated brachytherapy (IMBT). The purpose of this study evaluate the dosimetric characteristics bare/shielded using Monte Carlo (MC) simulations and perform an independent dose verification dosimetry platform based on multipoint plastic scintillator detector (mPSD). Methods TG‐43U1 parameters were calculated for model RapidBrachyMCTPS. Real‐time rate...
Intensity-modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide additional degree of freedom, but also introduce additional, directional, type uncertainty, compared conventional high-dose-rate (HDR BT).We propose and evaluate a robust optimization approach mitigate effects rotational uncertainty with respect planning criteria.A previously suggested prototype...
Fully coupled photon-electron-positron computational schemes are needed in a broad range of domains, from radiotherapy and radiosurgery treatment planning to nuclear-reactor safety analysis. Industrial deployment such remains problematic because the prohibitively time-consuming charged-particle-transport aspects both Monte Carlo algorithms Boltzmann-Fokker-Planck solvers. In this paper, partially scheme based on reactor-physics models for secondary photons (RPSPs) is presented. RPSPs include...
______________________________________________________________________________________________________spectral photon fluence and of the contributions by scattered primary photons were evaluated.The effects phantom material composition, especially organic polymer density amount inorganic additives, also studied in terms resulting linear attenuation coefficient μ.Results: Significant differences seen degree water equivalence between materials covered this study.While RW1, RW3, Solid Water, HE...
ConclusionOverall, good agreement is found between ACE and MC dose calculations in front of the eye plaques water.The consistent difference ~3-4% observed for all comparisons with simulations potentially due to differences simulation codes used generate data, scaling distribution water match TG-43 data OcB.Updated seed models will be investigate this discrepancy.The level indicates that further investigation applications involving a virtual, voxelized phantom, patient CT datasets, warranted.