A5075838950- Smoking Behavior and Cessation
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Behavioral Health and Interventions
- Consumer Attitudes and Food Labeling
- Obesity, Physical Activity, Diet
- Global Health Care Issues
- Nutritional Studies and Diet
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Genetic factors in colorectal cancer
- Long-Term Effects of COVID-19
- HER2/EGFR in Cancer Research
- Healthcare cost, quality, practices
- Optimism, Hope, and Well-being
- Health Policy Implementation Science
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
University of Michigan
2021-2025
Georgetown University Medical Center
2018-2021
Georgetown University
2018-2021
Georgetown Lombardi Comprehensive Cancer Center
2021
Metastatic breast cancer (MBC) treatment has changed substantially over time, but we do not know whether survival post-metastasis improved at the population level.We searched for studies of MBC patients that reported after metastasis in least two time periods between 1970 and present. We used meta-regression models to test improvement four disease groups: recurrent, recurrent estrogen (ER)-positive, ER-negative, de novo stage IV. performed sensitivity analyses based on bias some could lead...
Background: Screening mammography guidelines do not explicitly consider racial differences in breast cancer epidemiology, treatment, and survival. Objective: To compare tradeoffs of screening strategies Black women versus White under current guidelines. Design: An established model from the Cancer Intervention Surveillance Modeling Network simulated outcomes using race-specific inputs for subtype distribution; density; performance; age-, stage-, subtype-specific treatment effects; non–breast...
Introduction The US Food and Drug Administration most recently announced its intention to ban menthol cigarettes cigars nationwide in April 2021. Implementation of the will require evidence that it would improve public health. This paper simulates potential health impact a on through impacts smoking initiation, cessation switching nicotine vaping products (NVPs). Methods After calibrating an established simulation model reflect recent use trends cigarette NVP use, we extended incorporate...
Guidelines recommend offering cessation interventions to smokers eligible for lung cancer screening, but there is little data comparing specific approaches in this setting. We compared the benefits and costs of different smoking help screening programs select approaches.
We estimated the prevalence and mortality risks of preserved ratio impaired spirometry (PRISm) chronic obstructive pulmonary disease (COPD) in US adult population. linked three waves pre-bronchodilator data from National Health Nutritional Examination Survey (2007-2012) with Death Index. The analytic sample included adults ages 20 to 79 without missing on age, sex, height, BMI, race/ethnicity, smoking status. defined COPD (GOLD 1, 2, 3-4) PRISm using FEV1/FVC cut points by Global Initiative...
Abstract Introduction The US Food and Drug Administration announced its intention to ban menthol in cigarettes. However, information is needed on how a federal would affect population health. Aims Methods We conducted an expert elicitation gauge the impact of cigarette cigar United States. developed pilot tested questionnaire that focused tobacco use transitions current smokers (age 18–24 menthol, age 35–54 nonmenthol) potential 12–24). Using structured elicitation, we estimated mean net...
Objective: This study aimed to measure changes in preferences regarding health-related quality of life associated with COVID-19 and RSV illness children adults from 2021 (during the pandemic) 2023 (post-pandemic). Methods: A stated-preference survey elicited time trade-off (TTO) values US spring (n = 1014) summer 1186). Respondents were asked indicate how much they would hypothetically be willing trade end their avoid effects varying severities for: (1) children; (2) parents an ill child...
Abstract Objectives Novel non-invasive machine learning algorithms may improve accuracy and reduce the need for biopsy when diagnosing idiopathic pulmonary fibrosis (IPF). We conducted a cost-effectiveness analysis of diagnostic strategies IPF. Methods developed decision analytic model to evaluate IPF in United States. To assess full spectrum costs benefits, we compared four interventions: algorithm, genomic classifier, biopsy-all strategy, treat-all strategy. The was from health sector...
Introduction While much of the concern with tobacco industry marketing has focused on direct media advertising, a less explored form strategy is to discount prices. Price discounting important because it keeps purchase price low and can undermine impact tax increases. Methods We examine annual US expenditures from 1975 2019 by largest cigarette smokeless companies as reported Federal Trade Commission. consider three categories: promotional allowances discounting. In addition considering...
To identify differences in the approaches and results of studies that elicit equity-efficiency trade-offs can inform equity-informative cost-effectiveness analysis for healthcare resource allocation.We searched Ovid (Medline), EconLit, Scopus prior to June 25, 2021. Inclusion criteria were: (1) peer-reviewed or (2) gray literature; (3) published English; (4) survey-based; (5) parameterized a social welfare function quantify inequality aversion (6) elicited trade-off equity efficiency...
Tumor genomic expression profile data are used to guide chemotherapy choice, but there gaps in evidence for women aged 65 years and older. We estimate effects by age comorbidity level among with early-stage, hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers Oncotype DX scores of 26 or higher.A discrete-time stochastic state transition simulation model synthesized from population studies clinical trials outcomes over a 25-year horizon subgroups...
With the increasing changes in tobacco use patterns, "current use" definition and survey used may have important implications for monitoring population trends.
The public health impact of nicotine vaping products (NVPs) is subject to complex transitions between NVP and cigarette use. To circumvent the data limitations parameter instability challenges in modeling transitions, we indirectly estimate NVPs' on smoking prevalence resulting smoking-attributable deaths using SimSmoke simulation model. Canada uses age- sex-specific Canadian population, tobacco control policies. model incorporates cigarette-oriented policies but not explicit contribution...
In May 2020, the European Union Tobacco Products Directive mandated that EU member states, including Poland, ban sale of menthol cigarettes. With making up 28% cigarette sales before ban, Poland is country with likely largest share in world to their sale. We analyze how this changed Polish tobacco market.We use monthly NielsenIQ data (May 2018-April 2021) on cigarettes and roll-your-own by standard flavor eight regions Poland. set a bite-style regression model controlling for pre-ban share,...
Background Area-level indices are widely used to assess the impact of socio-environmental characteristics on cancer outcomes. While area-level measures socioeconomic status (SES) have been previously in settings, fewer studies focused evaluating health services supply (HSS) Moreover, there is significant variation methods and constructs create indices. Methods In this study, we introduced a psychometrically-induced, reproducible approach develop HSS SES We assessed utility these detecting...
In this study, we examined the effects of individual-level and area-level characteristics on advanced prostate cancer diagnosis among Medicare eligible older men (ages 70+ years). We analyzed patients from linked Surveillance, Epidemiology, End Results (SEER)-Medicare database (2000-2007) to US Census County Business Patterns data. Cluster-adjusted logistic regression models were used quantify individual preventive health behavior, clinical demographic characteristics, services supply,...