A5045799159- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Infant Health and Development
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Pediatric Pain Management Techniques
- Congenital Diaphragmatic Hernia Studies
- Nitric Oxide and Endothelin Effects
- Hospital Admissions and Outcomes
- Epilepsy research and treatment
- SARS-CoV-2 and COVID-19 Research
- Stress Responses and Cortisol
- Neonatal and Maternal Infections
- Kawasaki Disease and Coronary Complications
- Advanced Neuroimaging Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
Université de Reims Champagne-Ardenne
2015-2025
Centre Hospitalier Universitaire de Reims
2015-2025
Centre de Recherche en Sciences et Technologies de l'Information et de la Communication
2019-2025
Centre de Recherche en Économie et Statistique
2019-2025
Inserm
2008-2024
Centre d'Excellence en Technologies de l'Information et de la Communication
2018-2019
Hôpital Maison Blanche
2019
Hôpital Robert-Debré
2009-2018
Centre Hospitalier Universitaire Sainte-Justine
2015
Université de Montréal
2015
Activated microglia play a central role in the inflammatory and excitotoxic component of various acute chronic neurological disorders. However, mechanisms leading to their activation latter context are poorly understood, particularly involvement N-methyl-D-aspartate receptors (NMDARs), which critical for excitotoxicity neurons. We hypothesized that express functional NMDARs would trigger neuronal cell death brain by modulating inflammation.We demonstrate murine human nervous system these...
Objective To investigate the effects of melatonin treatment in a rat model white matter damage (WMD) developing brain. Additionally, we aim to delineate cellular mechanisms effect on oligodendroglial cell lineage. Methods A unilateral ligation uterine artery pregnant at embryonic day 17 induces fetal hypoxia and subsequent growth restriction (GR) neonatal pups. GR control pups received daily intra-peritoneal injection from birth post-natal (P) 3. Results Melatonin administration was...
Background Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates. However, little information known about its impact on developing brain submitted to excitotoxic challenge. Methodology/Principal Findings We investigated here effect iNO a neonatal model lesions. Rat pups and their dams were placed chamber containing 20 ppm NO during first week life. At postnatal day (P)5, rat intracranial injection glutamate agonists. P10, exposed exhibited significant decrease...
Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates, but there little information available about its effect on developing brain. We explored effects both iNO and endogenous NO white matter rodents. Rat or mouse pups their mothers were placed a chamber containing 5 to 20 ppm for 7 days after birth. Neonatal exposure was associated with transient increase central nervous system myelination rats C57BL/6 mice without any deleterious at low doses (5 ppm) behavioral...
SUMMARY Context: Non‐invasive ventilation (NIV) is increasingly used in pediatric intensive care units to limit the complications associated with intubation. However, NIV may fail, and delay initiating invasive be adverse outcomes. The objective of this retrospective study was evaluate safety tracheal intubation after failure. Methods: Consecutive procedures were prospectively evaluated our PICU from 01/2011 02/2012, as part National Emergency Airway Registry for Children (NEAR4KIDS)...
Depending on the initial pathology, hypovolemia, intra-abdominal hypertension, and sepsis are often encountered in neonatal digestive surgery. Accurate newborn monitoring during after surgery is essential to adapt resuscitation protocols. Near infrared spectroscopy (NIRS) non-invasive can detect hypoperfusion which indicates a low circulatory blood flow, regardless of cause.Evaluating changes cerebral renal regional oxygen saturation surgeries, conducted according normal practices, with...
To assess the ability of amplitude-integrated electroencephalography monitoring within 24 hours return spontaneous circulation to prognosticate neurologic outcomes in children following cardiac arrest DESIGN:: Retrospective review prospectively recorded data. An background score was calculated according activity during first after circulation, a higher correlating with more impaired activity. The primary endpoint outcome as defined by Pediatric Cerebral Performance Category at PICU discharge...
<h3>Importance</h3> An international expert committee recently revised its recommendations on amino acid intake for very preterm infants, suggesting that more than 3.50 g/kg/d should be administered only to infants in clinical trials. However, the optimal during first week after birth these is unknown. <h3>Objective</h3> To evaluate association between early and cognitive outcomes at age 5 years. <h3>Design, Setting, Participants</h3> Using EPIPAGE-2 (Epidemiologic Study...
Cerebellum injury is a severe and underestimated complication in very low birth-weight infants. Six cases of extreme premature babies are reported: 3 them died during the neonatal period; other survived with neurological disabilities. Microcephaly, strabismus, developmental delay without major motor handicap peculiar for preterm long-term outcome . Easy diagnosis possible by specific ultrasound windows early required regarding prognosis to organize precisely follow-up.
Abstract Objective Perinatal infections and the systemic inflammatory response to them are critical contributors white matter disease (WMD) in developing brain despite use of highly active antibiotics. Fluoroquinolones including ciprofloxacin (CIP) have intrinsic anti‐inflammatory effects. We hypothesized that CIP, addition its antibacterial activity, could exert a neuroprotective effect by modulating inflammation sepsis. Methods adapted an Escherichia coli sepsis model 5‐day‐old rat pups...
Purposes: Amplitude-integrated EEG (aEEG) has been widely developed in neonatal intensive care unit, but few studies focused on pediatric unit. Furthermore, reliability of aEEG under real-life conditions is unknown. Methods: Participants were nurses from a 12-bed unit referral university hospital France. Amplitude was implemented after standardized training, including e-learning course, individual feedback and bedside teaching concerning monitoring installation, background classification...
Inhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some evidence of its neuroprotective properties has been reported both mature and immature brains subjected to injury. NO key mediator the VEGF pathway, angiogenesis may be involved reduced vulnerability injury white matter cortex conferred by iNO. Here, we report effect iNO on developing brain potential effectors. We found that promotes during critical window P14 rat pups. This shift developmental program...
Objective: To investigate the effects of melatonin treatment in a rat model white matter damage (WMD) developing brain.Additionally, we aim to delineate cellular mechanisms effect on oligodendroglial cell lineage.Methods: A unilateral ligation uterine artery pregnant at embryonic day 17 induces fetal hypoxia and subsequent growth restriction (GR) neonatal pups.GR control pups received daily intra-peritoneal injection from birth post-natal (P) 3.Results: Melatonin administration was...
Background: Brain magnetic resonance imaging (MRI) is a key tool for the prognostication of encephalic newborns in context hypoxic−ischemic events. The purpose this study was to finely characterize brain injuries context. Methods: We provided complete, descriptive analysis MRIs infants included French national, multicentric cohort LyTONEPAL. Results: Among 794 eligible infants, 520 (65.5%) with MRI before 12 days life, grade II or III encephalopathy and gestational age ≥36 weeks were...