A5085511614- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Physiological and biochemical adaptations
- Insect Utilization and Effects
- Olfactory and Sensory Function Studies
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Circadian rhythm and melatonin
- Insect behavior and control techniques
- Regulation of Appetite and Obesity
- Insect and Pesticide Research
- Biomedical Ethics and Regulation
- Multisensory perception and integration
- Plant biochemistry and biosynthesis
- Silkworms and Sericulture Research
- Adipose Tissue and Metabolism
- Papaya Research and Applications
- Mosquito-borne diseases and control
- Plant and animal studies
- Pluripotent Stem Cells Research
- Ubiquitin and proteasome pathways
- 3D Printing in Biomedical Research
- Genetics, Aging, and Longevity in Model Organisms
- Agriculture Market Analysis Ukraine
- Insect Resistance and Genetics
Emory University
2022-2025
Columbia University
2013-2024
Brain (Germany)
2023
Georgetown University Medical Center
2016
Georgetown University
2016
University of California, San Francisco
2009-2013
Selection of appropriate oviposition sites is essential for progeny survival and fitness in generalist insect species, such as Drosophila melanogaster, yet little known about the mechanisms regulating how environmental conditions innate adult preferences are evaluated balanced to yield final substrate choice egg-deposition. Female D. melanogaster attracted food containing acetic acid (AA) an substrate. However, our observations reveal that this egg-laying preference a complex process, it...
Taste circuits are genetically determined to elicit an innate appetitive or aversive response, ensuring that animals consume nutritious foods and avoid the ingestion of toxins. We have examined response Drosophila melanogaster acetic acid, a tastant can be metabolic resource but also toxic fly. Our data reveal flies accommodate these conflicting attributes acid by virtue hunger-dependent switch in their behavioral this stimulus. Fed show taste aversion whereas starved robust response. These...
A fundamental question in sensory processing is how different channels of input are processed to regulate behavior. Different may converge onto common downstream pathways drive the same behaviors, or they activate separate distinct behaviors. We investigated this Drosophila bitter taste system, which contains diverse bitter-sensing cells residing organs. First, we optogenetically activated subsets neurons within each organ. These elicited broad and highly overlapping behavioral effects,...
Abstract Our sense of taste is critical for regulating food consumption. The fruit fly Drosophila represents a highly tractable model to investigate mechanisms processing, but circuits beyond sensory neurons are largely unidentified. Here, we use whole-brain connectome the organization circuits. We trace pathways from four populations that detect different modalities and project subesophageal zone (SEZ), primary region brain. find second-order primarily located within SEZ segregated by...
The relationship between alcohol consumption, sensitivity, and tolerance is an important question that has been addressed in humans rodent models. Studies have shown consumption risk of abuse may correlate with (1) increased sensitivity to the stimulant effects alcohol, (2) decreased depressant (3) tolerance. However, many conflicting results observed. To complement these studies, we utilized a different organism approach analyze ethanol other responses. Using set 20 Drosophila melanogaster...
In mammalian and insect models of ethanol intoxication, low doses stimulate locomotor activity whereas high induce sedation. Sex differences in acute responses, which occur humans, have not been characterized Drosophila. this study, we find that male flies show increased hyperactivity greater resistance to sedation compared with females. We the sex determination gene transformer (tra) acts developing nervous system, likely through regulation fruitless (fru), at least partially mediate sexual...
Alcohol abuse is a pervasive problem known to be influenced by genetic factors, yet our understanding of the mechanisms underlying alcohol addiction far from complete. Drosophila melanogaster has been established as model for studying molecular that mediate acute and chronic effects alcohol. However, not extended include more complex alcohol-related behaviors such self-administration. We recently paradigm characterize ethanol consumption preference in flies. demonstrated flies prefer consume...
Our sense of taste is critical for regulating food consumption. The fruit fly
SUMMARY A single sensory cue can elicit diverse behavioral responses. For example, the taste of sugar robustly promotes feeding 1, 2 but also influences other behaviors, such as altering locomotor patterns to maximize food-finding 3, 4 or conferring a rewarding value onto associated contexts cues. 5–7 Here, we investigate how sweet elicits multiple appetitive behaviors in Drosophila . Are different sugar-evoked coordinately regulated? At what point does circuit diverge into pathways that...
ABSTRACT The Arc genes — which include Drosophila Arc1 and Arc2 ( dArc ) evolved from Ty3 retrotransposons encode proteins that form virus-like capsids. These capsids enable a novel of intercellular communication by transferring RNAs between cells. However, the specific neuronal circuits brain processes signaling regulates remain unknown. Here, we show loss both in melanogaster enhances associative learning an appetitive conditioning paradigm, where flies associate odor with sugar rewards....
In both mammalian and insect models of ethanol intoxication, high doses induce motor impairment eventually sedation. Sensitivity to the sedative effects is inversely correlated with risk for alcoholism. However, genes regulating sensitivity are largely unknown. Based on a previous genetic screen in Drosophila sedation mutants, we identified novel gene, tank ( CG15626 ), homolog tumor suppressor EI24/PIG8 , which has strong role sensitivity. Genetic behavioral analyses revealed that acts...
Taste cues regulate immediate feeding behavior, but their ability to modulate future behavior has been less well studied. Pairing one taste with another can subsequent responses through associative learning, this requires simultaneous exposure both stimuli. We investigated whether modulates other tastes even when they do not overlap in time. Using Drosophila, we found that brief sugar enhanced responses, whereas bitter suppressed them. This modulation relies on neural pathways distinct from...
ABSTRACT The brain creates internal representations that translate sensory stimuli into appropriate behavior. Most studies of processing focus on which subsets neurons are activated by a stimulus, but the temporal features neural response also important for In taste system, timing peripheral responses has rarely been examined. We investigated properties in Drosophila melanogaster and discovered different types show striking differences their dynamics. Strong to stimulus onset (ON responses)...
ABSTRACT A fundamental question in sensory processing is how different channels of input are processed to regulate behavior. Different may converge onto common downstream pathways drive the same behaviors, or they activate separate distinct behaviors. We investigated this Drosophila bitter taste system, which contains diverse bitter-sensing cells residing organs. First, we optogenetically activated subsets neurons within each organ. These elicited broad and highly overlapping behavioral...