A5009908799- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Machine Learning in Bioinformatics
- Robotics and Sensor-Based Localization
- RNA and protein synthesis mechanisms
- Robotic Path Planning Algorithms
- Protein Structure and Dynamics
- Distributed and Parallel Computing Systems
- Fractal and DNA sequence analysis
- interferon and immune responses
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Modular Robots and Swarm Intelligence
- Interconnection Networks and Systems
- Synthesis and Characterization of Heterocyclic Compounds
- Parallel Computing and Optimization Techniques
- Porphyrin and Phthalocyanine Chemistry
- Crystallization and Solubility Studies
- Transgenic Plants and Applications
- Embedded Systems Design Techniques
- Insect Resistance and Genetics
- Various Chemistry Research Topics
- Bacterial Genetics and Biotechnology
- RNA regulation and disease
- Genetics, Bioinformatics, and Biomedical Research
University of Utah
2021-2024
L'Oréal (France)
2016
University of Massachusetts Dartmouth
2011
University of Rochester
2011
Oak Ridge National Laboratory
1987-2003
Albert Einstein College of Medicine
1992
University of Tennessee at Knoxville
1979
Columbia College
1962-1963
Columbia University
1960-1961
Abstract Current models of learning and memory have focused on cell-autonomous regulation synaptic strength; however, intercellular signaling between cells in the brain is critical for normal cognition. The immediate early gene Arc a repurposed retrotransposon long-term forms plasticity memory. protein virus-like capsids released extracellular vesicles (EVs) that signal cell-to-cell. Here, we find potentiation (LTP) stimuli induce biogenesis EVs by recruiting I-BAR IRSp53 to dendrites, which...
Identifying genes within large regions of uncharacterized DNA is a difficult undertaking and currently the focus many research efforts. We describe gene localization modeling system, called GRAIL. GRAIL multiple sensor-neural network-based system. It localizes in anonymous sequence by recognizing features related to protein-coding boundaries coding regions, then combines recognized using neural network Localized are "optimally" parsed into model. Through years extensive testing consistently...
Research focused on the development and experimental validation of intelligent control techniques for autonomous mobile robots able to plan perform a variety assigned tasks in unstructured environments is presented. In particular, an robot, HERMIES-IIB intelligence experiment series, described. It self-powered, wheel-driven platform containing onboard 16-node Ncube hypercube parallel processor interfaced effectors sensors through VME-based system Motorola 68020 processor, phased sonar array,...
In Drosophila, the transport regulator Klar displays tissue-specific localization: photoreceptors, it is abundant on nuclear envelope; in early embryos, absent from nuclei, but instead present lipid droplets. Differential targeting of appears to be due isoform variation. Droplet targeting, particular, has been suggested occur via a variant C-terminal region, LD domain. Although domain necessary and sufficient for droplet cultured cells, lack specific reagents had made previously impossible...
Nontoxic abrus lectin has been prepared by a new purification procedure. The method is accomplished 45% saturation ammonium sulfate fractionation from 5% acetic acid extract of the seeds Abrus precatorius followed diethylaminoethyl-Sephadex A-50 and Sepharose 4B affinity chromatography. appeared homogeneous as judged electrophoresis, analytical ultracentrifugation, isoelectric focusing. molecule weight 126,000 determined sedimentation equilibrium. It composed four subunits, which two pairs...
Abstract The ability to cleave specifically a human κ type Bence-Jones protein (LEN) into its amino-terminal (variant) half and carboxyl-terminal (constant) made possible the preparation isolation of variant in quantities sufficient for immunochemical physicochemical studies on properties light polypeptide chain. (Vl) was readily crystallized form suitable x-ray diffraction studies. Vl crystals were monoclinic with space group P2; unit cell dimensions from 13° precession photographs = 65.6 ±...
SUMMARY HERMIES-III is an autonomous robot comprised of a seven degree-of-freedom (DOF) manipulator designed for human scale tasks, laser range finder, sonar array, omnidirectional wheel-driven chassis, multiple cameras, and dual computer system containing 16-node hypercube expandable to 128 nodes. The current experimental program involves performance human-scale tasks (e.g., valve manipulation, use tools), integration dexterous platform motion in geometrically complex environments,...
ABSTRACT The Arc genes — which include Drosophila Arc1 and Arc2 ( dArc ) evolved from Ty3 retrotransposons encode proteins that form virus-like capsids. These capsids enable a novel of intercellular communication by transferring RNAs between cells. However, the specific neuronal circuits brain processes signaling regulates remain unknown. Here, we show loss both in melanogaster enhances associative learning an appetitive conditioning paradigm, where flies associate odor with sugar rewards....
We present an analysis of the protein fold recognition experiment using PROSPECT in The Third Community Wide Experiment on Critical Assessment Techniques for Protein Structure Prediction (CASP3). is a computer program we have recently developed finding optimal alignment between sequence and structural fold. Two unique features are (a) that it guarantees to find globally sequence–structure does so efficient manner, when alignment-scoring function consists three additive terms: (i) singleton...
A device has been designed and built to maintain a crystal in equilibrium with an atmosphere of constant relative humidity during X-ray photography the Buerger precession camera. The employs small constant-temperature enclosure, mounted directly on goniometer head resistance-wire winding is used supply amount heat enclosure. temperature maintained by thermistor-controlled electronic circuit. Temperature control not interrupted adjustments nor when film changed.
Protein threading provides an effective method for fold recognition and backbone structure prediction. But its application is currently limited due to level of prediction accuracy scope applicability. One way significantly improve usefulness through the incorporation underconstrained (or partial) NMR data. It well known that protein determination applies only small proteins effectiveness decreases rapidly as mass increases beyond about 30 kD. We present, in this paper, a computational...
Abstract A new crystalline form of abrin has been obtained from the most toxic constituent seed extract Abrus precatorius. An x-ray diffraction study shows that toxin crystallizes in a monoclinic unit cell probable symmetry P21 and parameters = 113 A, b 72 c 71 β 103°. The asymmetric contains 2 protein molecules molecular weight 63,800 solvent content approximately 45% by volume.