A5008288127- Renal and related cancers
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Medicinal plant effects and applications
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Advanced NMR Techniques and Applications
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Silymarin and Mushroom Poisoning
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- NMR spectroscopy and applications
- Metabolomics and Mass Spectrometry Studies
Instituto Nacional do Câncer
2017-2022
Universidade Federal de Ouro Preto
2014
University of California, San Francisco
1987
Neurological Surgery
1987
Abstract An experimental protocol for the quantitation of lactate is demonstrated in vivo 1 H NMR surface coil spectroscopy. The concentration can be calculated by comparing and vitro ratios N‐acetylaspartate (NAA) signals. With this protocol, approximately 25% present hypoxic or ischemic rat brain observed NMR. © 1987 Academic press Inc.
To identify underlying mechanisms involved with metastasis formation in Wilms tumors (WTs), we performed comprehensive DNA methylation and gene expression analyses of matched normal kidney (NK), WT blastemal component, metastatic tissues (MT) from patients treated under SIOP 2001 protocol. A linear Bayesian framework model identified 497 differentially methylated positions (DMPs) between groups that discriminated NK WT, but MT samples were divided two groups. Accordingly, variance grouped...
Abstract In vivo 1 H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/ N ‐acetylaspartate (NAA) ratio correlated with survival after and subsequent reperfusion. lactate/NAA that predicted death rats was estimated be approximately 1.3. © 1987 Academic Press, Inc.
Wilms tumor (WT) is a curable pediatric renal malignancy, but there need for new molecular biomarkers to improve relapse risk-directed therapy. Somatic alterations occur at relatively low frequencies whereas epigenetic changes 11p15 are the most common aberration. We analyzed long interspersed element-1 (LINE-1) methylation levels in blastemal component of WT and normal kidney samples explore their prognostic significance. presented hypomethylated pattern all five CpG sites compared matched...
Phosphorus-31 magnetic resonance (31P MR) spectroscopy was used to obtain serial in vivo measurements of cerebral adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi), and intracellular pH levels rats during temporary global ischemia reperfusion. Three groups 4 each that recovered from permanent bilateral vertebral artery occlusion were placed a MR spectrometer subjected remotely controlled carotid lasting 6, 15, or 30 minutes followed by 1 hour Four additional...
Pediatric cancer NMR-metabonomics might be a powerful tool to discover modified biochemical pathways in tumor development, improve diagnosis, and, consequently, treatment. Wilms (WT) is the most common kidney young children whose genetic and epigenetic abnormalities lead cell metabolism alterations, but, so far, investigation of metabolic WT scarce. We aimed explore high-resolution magic-angle spinning nuclear magnetic resonance (HR-MAS NMR) metabonomics normal (NK) samples. For this study,...