A5014537908- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Ultrasound and Hyperthermia Applications
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Orthopaedic implants and arthroplasty
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Antenna Design and Analysis
- Tendon Structure and Treatment
- Congenital Ear and Nasal Anomalies
- Ultrasound and Cavitation Phenomena
- Bone health and treatments
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Ultrasound Imaging and Elastography
- Bone Metabolism and Diseases
- interferon and immune responses
- Hydrogels: synthesis, properties, applications
- Neonatal skin health care
Massachusetts Institute of Technology
2024-2025
Brigham and Women's Hospital
2024-2025
Harvard University
2024-2025
Ben-Gurion University of the Negev
2014-2024
We hypothesize that the biomechanical properties of cells can predict their viability, with Young's modulus representing former and cell sensitivity to ultrasound latter. Using atomic force microscopy, we show stiffness measure is significantly lower for superficial cancer (squamous carcinomas melanoma) compared noncancerous keratinocyte cells. In vitro findings reveal a significant difference between cancerous viability at four energy levels evaluated, different lines exhibiting...
Abstract Starch‐based nanoparticles are highly utilized in the realm of drug delivery taking advantage their biocompatibility and biodegradability. Studies have Quaternized starch (Q‐starch) for small interfering RNA (siRNA) delivery, which quaternary amines enable interaction with negatively charged siRNA, resulting self‐assembly complexation. Although reports present numerous applications, demonstrated efficacy is nonetheless limited due to undiscovered cellular mechanistic delivery. In...
Introduction Over 6.8 million fractures occur annually in the US, with 10% experiencing delayed- or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and small molecule salt inducible kinase (SIK) inhibitors mimic action. This study tests whether SIK inhibitor YKL-05-099 accelerates callus osteogenesis. Methods 126 female mice underwent femoral shaft pinning midshaft fracture, receiving daily injections of PBS, YKL-05-099, PTH. Callus tissues were analyzed via...
RNA interference (RNAi) therapy has emerged as a promising cancer platform; however, there is an ongoing need for safe and effective delivery carrier siRNA. The present study demonstrates the first time systemic in vivo of nanosized complexes quaternized starch (Q-starch) siRNA to effectively target murine model. Our results show that Q-starch/siRNA composite nanoparticle are administration, with no evident toxicities. Encouragingly, demonstrate their cellular uptake tumor 63% gene silencing...
In this research, combined effect of chlorin e6 and noninvasive 20 kHz, low-powered ultrasound on melanoma cells is proposed for the first time. The combination incorporates application safe low-frequency that used transdermal drug delivery. We demonstrate impact kHz leads to strong sonodynamic in cells. also show keeps its monomeric form does not aggregate after exposure ultrasound. propose a two-step model where sonoluminescence serves as an internal light source photoactivation.
The tetrapyrrole chlorin e6 (Ce6) is actively used in photodynamic therapy (PDT) and as a test drug for sonodynamic due to its ability generate singlet oxygen. In this work, we have analyzed the absorption, photoluminescence (PL), PL excitation spectra of Ce6 molecules nutrient medium inside melanoma cells. An analysis results shows that cancer cells with low pH remains monomeric form. A has also been conducted confirmed effect produced by changing signals from absorption spectra.
In this research, combined effect of chlorin e6 and noninvasive 20 kHz, low-powered ultrasound on melanoma cells is proposed for the first time. The combination incorporates application safe low-frequency that used transdermal drug delivery. We demonstrate impact kHz leads to strong sonodynamic in cells. also show keeps its monomeric form does not aggregate after exposure ultrasound. propose a two-step model where sonoluminescence serves as an internal light source photoactivation.