A5028083751- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Cancer-related cognitive impairment studies
- Parkinson's Disease Mechanisms and Treatments
- Gut microbiota and health
- Family Support in Illness
- Autism Spectrum Disorder Research
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Vaccine Coverage and Hesitancy
- Sexual function and dysfunction studies
- Diabetes Management and Education
- Complementary and Alternative Medicine Studies
- COVID-19 and Mental Health
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
Chinese University of Hong Kong
2016-2025
University of Hong Kong
2020
McCarthy Family Foundation
2019
University of Bath
2017
Ten Chen Hospital
2017
Kwong Wah Hospital
2017
University College London
2013
CARE Canada
2012
University of London
2010
Medway School of Pharmacy
2009
A collection of 2,209 isolates six polysaccharide capsule types Haemophilus influenzae, including 1,975 serotype b recovered in 30 countries was characterized for electrophoretically demonstrable allele profiles at 17 metabolic enzyme loci. Two hundred eighty distinct multilocus genotypes were distinguished, and cluster analysis revealed two primary phylogenetic divisions. The population structure encapsulated H. influenzae is clonal. Currently, most the invasive disease worldwide caused by...
A ten-year series of 142 homicidal fatalities caused by sharp force injury was studied with the aim to systematize information inherent in characteristics victim and pattern injuries. The population victims consisted 112 males (79%) 30 females (21%); among perpetrators, 125 (88%) were males. Among as well persons non-Swedish origin overrepresented relation their share nonselected population. In 82 cases (58%), one or two wounds had been inflicted; 23 (16%), ten more wounds. latter group,...
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain exhibits GTPase activity controlling kinase via an intramolecular process. We report interaction with dishevelled family phosphoproteins (DVL1-3), key regulators Wnt (Wingless/Int) signalling pathways important for axon guidance, synapse formation and neuronal maintenance. Interestingly, DVLs can interact mediate activation small GTPases structural similarity to Roc...
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are most prevalent known cause of autosomal dominant Parkinson's disease. The LRRK2 encodes a Roco protein featuring Ras complex proteins (ROC) GTPase and domain linked by C-terminal ROC (COR) domain. Here, we explored effects Y1699C pathogenic mutation COR on activity interactions within catalytic core LRRK2. We observed decrease for comparable to R1441C mutant T1348N dysfunctional mutant. To study underlying mechanism, dimerization...
This study assessed the knowledge, attitudes and practices (KAP) towards coronavirus disease 2019 (COVID-19) among South Asians in Hong Kong examined factors that affect KAP COVID-19 this population. cross-sectional descriptive recruited participants with assistance from Asian community centres organisations. A total of 352 completed questionnaires to assess their level COVID-19. The mean knowledge score was 5.38/10, indicating a relatively low level. expressed certain misconceptions...
In a prospective study of 1,000 people treated by vasectomy at the Margaret Pyke Centre under local anaesthesia as outpatients minor sepsis occurred in 12 cases, an abscess one, and haematoma needing drainage seven. Spontaneous recanalization vasa six patients unsuspected third vas was found one.Except with or semen always free from motile spermatozoa within three months, but non-motile have so far persisted for up to 17 months few cases.
Background Head and neck cancer (HNC) survivors face increasing challenges to adjust the diagnosis late effects of treatment. Identifying unmet needs among HNC is therefore important provide a comprehensive supportive care service for them. Objective The aim this study was examine (SCNs) in first year after Methods An explanatory sequential mixed-method design with 2 phases used. In quantitative phase, standardized questionnaires were administered 285 Chinese solicit their demographic...
Rice bran exhibits chemopreventive properties that may help to prevent colorectal cancer (CRC), and a short-term rice dietary intervention promote intestinal health via modification of the microbiota. We conducted pilot, double-blind, randomised placebo-controlled trial assess feasibility implementing long-term (24-week) in Chinese subjects with high risk CRC, examine its effects on composition their Forty were into group (n = 19) or control 20). The participants consumed 30 g over 24-h...
Abstract Background Cancer patients often experience severe financial distress due to the high cost of their treatment, and strategies are needed objectively measure this distress. The COmprehensive Score for Toxicity-Functional Assessment Chronic Illness Therapy (COST-FACIT) is one instrument used such This study aimed translate COST-FACIT (Version 2) [COST-FACIT-v2] into traditional Chinese (COST-FACIT-v2 [TC]) evaluate its psychometric properties. Methods Functional (FACIT) translation...