A5058250895- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neurological Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Prenatal Substance Exposure Effects
- Prion Diseases and Protein Misfolding
- Neurotransmitter Receptor Influence on Behavior
- Nutritional Studies and Diet
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medicinal Plants and Neuroprotection
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Atherosclerosis and Cardiovascular Diseases
- Neuroendocrine regulation and behavior
- Diabetes Treatment and Management
- 14-3-3 protein interactions
- Consumer Attitudes and Food Labeling
- Lipoproteins and Cardiovascular Health
Christian Brothers University
2025
La Trobe University
2020
University of California, Irvine
1999-2009
Various environmental and genetic factors influence the onset progression of Alzheimer’s disease (AD). Dysregulation hypothalamic–pituitary–adrenal (HPA) axis, which controls circulating levels glucocorticoid hormones, occurs early in AD, resulting increased cortisol levels. Disturbances HPA axis have been associated with memory impairments may contribute to cognitive decline that although it is unknown whether such effects involve modulation amyloid β-peptide (Aβ) tau. Using vitro vivo...
Transgenic mouse models of Alzheimer's disease (AD), such as the 3xTg-AD mice, are instrumental for elucidating genetic, pharmacologic, environmental, and behavioral factors that affect cognitive phenotype. Here we present novel findings longitudinal water-maze spatial training produces a significant, albeit transient, improvement in subsequent learning performance reduces amyloid β (Aβ) tau neuropathology. The mice were trained tested at 3 month intervals from 2 to 18 months. Separate...
<title>Abstract</title> Cannabis use during pregnancy is common as many pregnant women consider cannabis a safe way to alleviate symptoms associated with because it “natural”. However, clinical evidence links perinatal exposure externalizing behavior in offspring including impulsivity, hyperactivity, and substance use. In preclinical research, most studies focus on the psychoactive constituent of cannabis, delta-9-tetrahydrocannabinol (THC). THC lipophilic allowing cross placental barrier be...
The globus pallidus (GP) consists of two neuron populations, distinguished according to their immunoreactivity for parvalbumin (PV). PV-immunoreactive (PV+) neurons project preferentially “downstream” targets such as the subthalamic and entopeduncular nuclei, whereas lacking PV (PV– neurons) striatum, suggesting a role PV– cells in feedback striatal neurons. Although dopamine D2 antagonist administration induces immediate early gene expression GP neurons, little is known about long-term...
The M1 muscarinic receptor (M1 mAChR), preserved in Alzheimer's disease (AD), is a pivotal target that links major hallmarks of AD, e.g. cholinergic deficiency, cognitive dysfunctions, β–amyloid (Aβ) and tau pathologies. Some agonists, although effective had limited clinical value due to adverse effects lack selectivity. M1–selective agonists AF102B [Cevimeline], AF150(S) AF267B lead to: i) elevated αAPPs, decreased Aβ levels hyperphosphorylation, blocked Aβ–induced neurotoxicity, vitro, via...
Alzheimer's disease is characterized by deficits in brain systems related to memory and other cognitive functions. Transgenic models are instrumental for elucidating the genetic, pharmacologic, environmental, behavioral factors that affect phenotype. The 3xTg–AD mice develop age–dependent region–specific Aβ tau pathology, early at 4 months of age, dependent upon appearance intraneuronal Aβ. Our goals were determine how learning/memory was impacted as a function age evaluate various modulate...