A5060130159- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Helicobacter pylori-related gastroenterology studies
- Escherichia coli research studies
- Genomics, phytochemicals, and oxidative stress
- Hemoglobin structure and function
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Quinazolinone synthesis and applications
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Actinomycetales infections and treatment
University of Geneva
2023-2024
Université de Versailles Saint-Quentin-en-Yvelines
2021-2023
Inserm
2021-2023
Université Paris-Saclay
2021-2023
Institut Pasteur
2021
Centre National de la Recherche Scientifique
2021
Cells have two purine pathways that synthesize adenine and guanine ribonucleotides from phosphoribose via inosylate. A chemical hybrid between guanine, 2-aminoadenine (Z), replaces in the DNA of cyanobacterial virus S-2L. We show S-2L Vibrio phage PhiVC8 encode a third pathway catalyzed by PurZ, distant paralog succinoadenylate synthase (PurA), enzyme condensing aspartate inosylate pathway. PurZ condenses with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes...
Mycobacterium abscessus is the most pathogenic species among predominantly saprophytic fast-growing mycobacteria. This opportunistic human pathogen causes severe infections that are difficult to eradicate. Its ability survive within host was described mainly with rough (R) form of M . , which lethal in several animal models. R not present at very beginning disease but appears during progression and exacerbation mycobacterial infection, by transition from a smooth (S) form. However, we do...
Non-tuberculous mycobacteria (NTM) are a large group of micro-organisms comprising more than 200 individual species. Most NTM saprophytic organisms and found mainly in terrestrial aquatic environments. In recent years, have been increasingly associated with infections both immunocompetent immunocompromised individuals, prompting significant efforts to understand the diverse pathogenic signalling traits these emerging pathogens. Since discovery Type VII secretion systems (T7SS), there...
ESX type VII secretion systems are complex machineries spanning across the mycobacterial membrane and play an important role in pathogenicity, nutrient uptake conjugation. We previously reported of ESX-4 modulating Mycobacterium abscessus intracellular survival. The loss EccB4 was associated with limited two effector proteins belonging to WXG-100 family, EsxU EsxT, encoded by esx-4 locus. This prompted us investigate function M . EsxT vitro vivo Herein, we show that substrates form a stable...
Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is a significant threat to public health worldwide. The primary reservoir for CR-Kp the intestinal tract. There, bacterium usually present at low density but can bloom following antibiotic treatment, mostly in hospital settings. impact of disturbances environment on fitness, survival, expansion, and drug susceptibility this pathogen not well-understood, yet it may be relevant devise strategies tackle colonization infection. Here, we adopted...
Establishing the rapid and accurate diagnosis of sepsis is a key component to improvement clinical outcomes. The ability analytical platforms rapidly detect pathogen-associated molecular patterns (PAMP) in blood could provide powerful host-independent biomarker sepsis. A novel concept was investigated based on idea that pre-bound fluorescent ligand be released from lectins contact with high-affinity ligands (such as PAMPs). To create precise avidity, kinetically followed TEMPO oxidation...