A5070809593- Sulfur Compounds in Biology
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Connexins and lens biology
- Biochemical effects in animals
- Cellular transport and secretion
- Autoimmune and Inflammatory Disorders Research
- Amino Acid Enzymes and Metabolism
- Lysosomal Storage Disorders Research
- Drug Transport and Resistance Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- Aldose Reductase and Taurine
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience and Neuropharmacology Research
- Glutathione Transferases and Polymorphisms
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Advanced Glycation End Products research
- Redox biology and oxidative stress
University of California, Los Angeles
2018-2022
Doheny Eye Institute
2020
University of Auckland
2012-2017
Significance Cell nonautonomous toxicity is involved in various neurodegenerations, but mechanistic understanding limited. Here, we provide insight into cellular mechanisms underlying a dominant macular degeneration, which results from mutant ELOVL4 , and represents an unusual case of two separate cell events. We demonstrate that the first event involves RPE phagocytosis photoreceptor disc membranes contain mislocalized protein. show phagosomes are degraded inefficiently, thus introducing to...
The photoreceptor outer segment (OS) is the phototransductive organelle in vertebrate retina. OS tips are regularly ingested and degraded by adjacent retinal pigment epithelium (RPE), offsetting addition of new disk membrane at base OS. This catabolic role RPE essential for health, with defects ingestion or degradation underlying different forms degeneration blindness. Although proteins required tip have been identified, spatiotemporal analysis process live cells lacking; hence, literature...
Purpose: To identify and functionally characterize transporters involved in the release of glutathione (GSH) conjugates from rat lens. Methods: Polymerase chain reaction Western blotting were used to screen for presence multidrug resistance–associated protein (Mrp) organic anion transporting polypeptide (Oatp) isoforms, immunohistochemistry localize Mrp isoforms. test function, lenses loaded with 5-chloromethylfluorescein diacetate monochlorobimane form fluorescent GSH methylfluorescein...
Chediak–Higashi syndrome, caused by mutations in the Lys osome T rafficking Regulator ( Lyst ) gene, is a recessive hypopigmentation disorder characterized albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of lysosomes lysosome-related organelles. Although recent studies have suggested that impair regulation sizes lysosome organelle, underlying pathogenic mechanism syndrome still unclear. Here we show striking evidence deficiency LYST protein...
ABSTRACT Chediak–Higashi syndrome, caused by mutations in the Lys osome T rafficking Regulator ( Lyst ) gene, is a recessive hypopigmentation disorder characterized albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of lysosomes lysosome-related organelles. Although recent studies have suggested that impair regulation sizes lysosome organelle, underlying pathogenic mechanism syndrome still unclear. Here we show striking evidence deficiency LYST...