A5100697615- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Global Public Health Policies and Epidemiology
- Mast cells and histamine
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Carcinogens and Genotoxicity Assessment
- Genetic Mapping and Diversity in Plants and Animals
- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- Cardiovascular Health and Risk Factors
- Hippo pathway signaling and YAP/TAZ
- Genetics and Plant Breeding
- Antibiotic Resistance in Bacteria
- Paraquat toxicity studies and treatments
- Health Promotion and Cardiovascular Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
Sichuan University
2025
West China Hospital of Sichuan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Kunming Medical University
2024
Fuwai Yunnan Cardiovascular Hospital
2024
Jiangsu Academy of Agricultural Sciences
2021-2023
University of Kansas Medical Center
2016-2023
University of California, San Diego
2021
Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver macrophages and directly binds complement component C3b or Gram-positive bacteria to mediate phagocytosis. CRIg plays important roles in several immune-mediated diseases, but it not clear how its pathogen recognition phagocytic functions maintain homeostasis prevent disease. We previously associated cytolysin-positive Enterococcus faecalis with severity alcohol-related Here, we demonstrate that reduced tissues...
To analyze the risk factors for mortality in patients with acute diquat (DQ) poisoning and construct a nomogram prediction model clinical assessment treatment. A retrospective analysis was performed on data of 110 DQ who were admitted from March 2022 to April 2024. The enrolled divided into training set 80 cases validation 30 cases. survival group death established, within days as endpoint. Among these, group, there 67 13 group. This study further analyzed compared baseline two groups...
Wound healing consists of three overlapping phases: inflammation, proliferation, and matrix synthesis remodeling. Prolonged alcohol abuse can cause liver fibrosis due to deregulated Previous studies demonstrated that moderate ethanol feeding enhances fibrogenic markers frank independent differences in CCl4-induced injury. Our objective was determine whether or not other phases the hepatic wound response were affected by after CCl4 exposure. Mice fed (2% v/v) for two days then exposed...
Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated HAS3 promotes inflammation pathogenic in animal models of human lung intestinal disease. Liver fibrosis common endpoint to chronic liver injury for which there no cure. Although plasma commonly used biomarker disease, if how contributes disease pathogenesis remains unclear. Here, we tested the hypothesis that enhances...
Biological differences exist between strains of laboratory mice, and it is becoming increasingly evident that there are substrains. In the C57BL/6 mouse, primary substrains called 6J 6N. Previous studies have demonstrated 6N mice differ in response to many experimental models human disease. The aim our study was determine if terms their acute carbon tetrachloride (CCl 4 ) exposure. Mice were given CCl once euthanized 12 96 h later. Relative we found had increased liver injury but more rapid...
Autosomal recessive polycystic kidney disease/congenital hepatic fibrosis (ARPKD/CHF) is a rare but fatal genetic disease characterized by progressive cyst development in the kidneys and liver. Liver cysts arise from aberrantly proliferative cholangiocytes accompanied pericystic inflammation. Yes-associated protein (YAP), downstream effector of Hippo signaling pathway, implicated human malignancies such as hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, its role cystogenesis...
Under the background of similar geography and culture in Lancang-Mekong countries rapid changes regional economy lifestyle, this study aimed to describe compare prevalence, awareness, treatment, control hypertension assess care cascade three provinces China, Laos, Cambodia. A cross-sectional was conducted between 2021 2023 Lancang–Mekong River using consistent investigative procedures. We included 11,005 participants aged ≥ 18 years from provinces, data were collected through questionnaires,...
Autosomal recessive polycystic kidney disease (ARPKD) is a monogenic characterized by development of hepatorenal cysts, pericystic fibrosis, and inflammation. Previous studies show that mast cell (MC) mediators such as histamine induce proliferation cholangiocytes. We observed robust MC accumulation around liver but not in (PCK) rats (an animal model ARPKD). Therefore, we hypothesized MCs contribute to hepatic cyst growth ARPKD. To test this hypothesis, treated PCK with 1 2 different...
Abstract Background Heterosis has been widely used in maize breeding. However, we know little about the heterotic quantitative trait loci and their roles genomic prediction. In this study, sought to identify for seedling biomass-related traits using triple testcross design compare prediction accuracies by fitting molecular markers loci. Results A population comprised of 366 genotypes was constructed crossing each 122 intermated B73 × Mo17 with B73, Mo17, Mo17. The mid-parent heterosis...
Congenital hepatic fibrosis / Autosomal recessive polycystic kidney disease (CHF/ARPKD) is an inherited neonatal induced by mutations in the PKHD1 gene and characterized cysts, robust pericystic liver kidney. The PCK rat excellent animal model which carries a Pkhd1 mutation exhibits similar pathophysiology. We performed RNA-Seq analysis on samples from rats over time course of postnatal day (PND) 15, 20, 30, 90 using age-matched Sprague-Dawley (SD) as controls to characterize molecular...
Congenital hepatic fibrosis/Autosomal recessive polycystic kidney disease (CHF/ARPKD) is an inherited neonatal induced by mutations in the PKHD1 gene and characterized cysts robust pericystic fibrosis liver kidneys. The PCK rat excellent animal model that carries a Pkhd1 mutation exhibits similar pathophysiology. We performed RNA-Seq analysis on samples from rats over time course of postnatal day (PND) 15, 20, 30, 90 using age-matched Sprague Dawley (SD) as controls to characterize molecular...