Immunotherapy is a leading approach for treating advanced non-small cell lung cancer (NSCLC) by targeting the PD-1/PD-L1 checkpoint signaling pathway, particularly in tumors expressing high levels of PD-L1 (Jug et al. J Am Soc Cytopathol 9:485-493, 2020; Perrotta Chest 158: 1230-1239, 2020). Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) minimally invasive method to obtain tissue molecular studies, including analysis, unresectable (Genova Front Immunol 12:...

Abstract Purpose The use of endobronchial ultrasound (EBUS) is standard practice for lung cancer diagnosis and staging. Next generation sequencing (NGS) detection genetic alterations recommended in advanced, non-squamous, non-small-cell (NSCLC). Existing protocols NGS testing are minimal reported yields vary. This study aimed to determine the yield EBUS samples obtained using a sampling protocol at our institution assess predictive factors form collection protocols. Methods We reviewed...

We present a case of 63-year-old male with an 8-year history left-sided cystic facial mass which recurred despite multiple drainage procedures. Imaging findings showed in the left parotid gland and it was surgically resected. Pathology confirmed to represent mammary analogue secretory carcinoma, relatively newly described entity. This illustrates that carcinoma can masquerade as cyst within gland.

Myeloid sarcoma (MS) is an extramedullary manifestation of acute myeloid leukemia (AML) and commonly occurs in sites such as the lymph nodes, skin, soft tissues, bone. It more rarely manifests pancreas, with less than 20 cases reported literature since 1987. Despite its rarity, MS should be considered differential diagnosis a tissue mass causing obstructive jaundice, especially if patient has known hematologic disease. Isolated pancreatic have been to progress AML; therefore, it crucial...

Hamid, Ramiz N. MD, MPH; Dorrell, Deborah MD; Niehaus, Angela G. Savas, Jessica A. MD Author Information

Without prompt diagnosis and treatment, patients with Lyme disease may develop life threatening multi-organ system complications. As such, we discuss the key diagnostic features of condition along patient-specific suggested treatment protocols. Additionally, is reportedly expanding to regions that were previously not impacted, epidemiological are outlined. We a patient severe who presented widespread cutaneous involvement atypical pathologic findings within an uncharacteristic geographic...

Pena, Joseph MS*; Zameza, Priscila Arellano Ogbonna, Chiagoziem BS*; Niehaus, Angela MD*,†; Ahn, Christine MD*,† Author Information

Pena, Joseph MS*; Zameza, Priscila Arellano Ogbonna, Chiagoziem BS*; Niehaus, Angela MD*,†; Ahn, Christine MD*,† Author Information

Purpose: To evaluate the influence of isotope and prostate size on International Prostate Symptom Score (IPSS) normalization, catheter dependency need for surgical intervention following permanent brachytherapy. Method Materials: 976 consecutive patients underwent brachytherapy clinical stage T1b‐T3a cancer. Of these, 789 were implanted with Pd‐103 187 I‐125. Patients stratified into cohorts ⩽ 25.0 cm 3 , 25–35 35–45 > 45.0 . 418 received androgen deprivation therapy (ADT). 486...

Significant advances in targeted therapy have been made recent years for patients with lung adenocarcinoma. These therapies molecular testing of paramount importance to drive therapeutic decisions. Material is often limited, particularly cytology specimens and small core biopsies. A reliable screening tool invaluable triaging limited tissue selection epidermal growth factor receptor ( EGFR) mutation testing. We hypothesized that the immunohistochemistry (IHC) profile adenocarcinoma predicts...

Departments of *Dermatology, and †Pathology, Wake Forest School Medicine, Winston-Salem, NC. Correspondence: Jeremy K. Bray, BA, Department Dermatology, Medical Center Boulevard, NC 27157-1071 (e-mail: [email protected]). The authors declare no conflicts interest.

Departments of *Dermatology, and †Pathology, Wake Forest School Medicine, Winston-Salem, NC. Correspondence: Jeremy K. Bray, BA, Department Dermatology, Medical Center Boulevard, NC 27157-1071 (e-mail: [email protected]). The authors declare no conflicts interest.

Introduction: Obstructive jaundice is a common clinical manifestation of pancreatic cancer (PC), over 90% which are ductal adenocarcinoma. Myeloid sarcoma (MS) an extramedullary acute myeloid leukemia rarely occurs in the pancreas. We report rare cause obstructive jaundice- MS pancreas oldest patient and second to require endoscopic retrograde cholangiopancreatography (ERCP) reported literature.1 Case Description/Methods: A 70-year-old man with recently diagnosed eyelid presented epigastric...

Introduction: Retroperitoneal sarcomas are a rare clinical finding, accounting for only 1-2% of solid malignancies.1 The proximity these tumors to nearby retroperitoneal organs may lead false or delayed diagnoses; however, endoscopic ultrasound (EUS) is useful tool in characterization and surgical planning lesions. We report case patient with mass thought be originating from the pancreatic parenchyma, but ultimately recognized as leiomyosarcoma, independent pancreas. Case...