Abstract Metal–organic frameworks (MOFs) are hybrid porous crystalline networks with tunable chemical and structural properties. However, their excellent potential is limited in practical applications by hard‐to‐shape powder form, making it challenging to assemble MOFs into macroscopic composites mechanical integrity. While a binder matrix enables materials, such materials have MOF content thus functionality. To overcome this challenge, nanoMOFs combined tailored same‐charge...

Natural extracellular matrix (ECM) consists of complex signals interacting with each other to organize cellular behavior and responses. This sophisticated microenvironment can be mimicked by advanced materials presenting essential biochemical physical properties in a synergistic manner. In this work, we developed facile fabrication method for novel nanofibrous self-assembled peptide amphiphile (PA) poly(ethylene glycol) (PEG) composite hydrogel system independently tunable biochemical,...

Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA have significant advantages controlled delivery applications due to their high capacity retain water, biocompatibility, biodegradability. In this study, we demonstrate injectable drug applications. Doxorubicin (Dox), as widely used chemotherapeutic breast cancer treatment, was encapsulated within the prepared at...

Multifunctional, light-weight, responsive materials show promise in a range of applications including soft robotics, therapeutic delivery, advanced diagnostics and charge storage. This paper presents novel, scalable, efficient sustainable approach for the preparation cellulose nanofibril-based aerogels via facile ice-templating, solvent exchange air-drying procedure, which could replace existing inefficient drying processes. These ambient-dried (∼99% porosity) exhibit high specific...

Interpolymer association in aqueous solutions is essential for many industrial processes, new materials design, and the biochemistry of life. However, our understanding mechanism limited. Classical theories do not provide molecular details, creating a need detailed mechanistic insights. This work consolidates previous literature with complementary isothermal titration calorimetry (ITC) measurements dynamics (MD) simulations to investigate mechanisms such The large body ITC data shows that...

Label free imaging of the chemical environment biological specimens would readily bridge supramolecular and cellular scales, if a fingerprint technique such as Raman scattering can be coupled with super resolution imaging. We demonstrate possibility label-free super-resolution imaging, by applying stochastic reconstruction to temporal fluctuations surface enhanced (SERS) signal which originate from biomolecular layers on large-area plasmonic surfaces high uniform hot-spot density (>1011/cm2,...

Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical biotechnological applications, including tissue engineering, regenerative medicine, or drug delivery. In this study, authors report fabrication of hybrid multilayered biomaterials, comprising high‐molecular‐weight biopolymers oppositely charged low‐molecular‐weight peptide amphiphiles (PAs), combination...

There are many bioelectronic applications where the additive manufacturing of conductive polymers may be use. This method is cheap, versatile and allows fine control over design wearable electronic devices. Nanocellulose has been widely used as a rheology modifier in bio-based inks that to print electrical components However, preparation nanocellulose energy time consuming. In this work an easy-to-prepare, 3D-printable, bio-ink; based on modified cellulose fibers poly(3,4-ethylene...

Amyloid peptides are important components in many degenerative diseases as well maintaining cellular metabolism. Their unique stable structure provides new insights developing materials. Designing bioinspired self-assembling is essential to generate forms of hierarchical nanostructures. Here we present oppositely charged amyloid inspired (AIPs), which rapidly self-assemble into nanofibers at pH 7 upon mixing water caused by noncovalent interactions. Mechanical properties the gels formed...

Abstract Synthetic vaccines utilize viral signatures to trigger immune responses. Although the responses raised against biochemical of viruses are well characterized, mechanism how they affect response in context physical is not studied. In this work, we investigated ability zero- and one-dimensional self-assembled peptide nanostructures carrying unmethylated CpG motifs (signature DNA) for tuning response. These represent two most common shapes, spheres rods. The nanofibrous structures were...

For the successful commercialisation of microfibrillated cellulose (MFC) it is utmost importance to carefully characterise constituent particles. This could for instance lead development MFC grades with size distributions tailored specific applications. Characterization challenging due heterogeneous chemical and structural nature MFC. study describes a fractionation approach that combines two steps physical sieving larger particles final centrifugation step separate out smallest, colloidally...

Controlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up possibility developing biocompatible functional materials for various applications. In this study, we show that self-assembly histidine- (His-) functionalized PAs containing d- or l-amino acids can be controlled by both solution pH and molecular chirality building blocks. An increase in resulted structural transition His-functionalized chiral PA assemblies from...

Guidance of neurite extension and establishment neural connectivity hold great importance for tissue regeneration conduit implants. Although bioactive-epitope functionalized synthetic or natural polymeric materials have been proposed the induction regeneration, chemical modifications these differentiation still remain a challenge due to harsh conditions reactions, along with non-homogeneous surface modifications. In this study, facile noncovalent functionalization method is by exploiting...

Abstract Industrial production of low-charge microfibrillated cellulose (MFC) typically results in wide fibril size distributions. This polydispersity influences viscosity, overall colloidal stability, and rheological properties MFC suspensions gels aqueous systems. In this work, a systematic analysis is performed for industrially prepared fractions different Gel formation flow characteristics (e.g., shear-thinning) each fraction are examined under neutral acidic conditions compared with the...

Mussel-inspired polydopamine (PDA) initiates a multifunctional modification route that leads to the generation of novel advanced materials and their applications. However, existing PDA deposition techniques still exhibit poor spatial control, have very limited capability micropatterning, do not allow local tuning topography. Herein, based on multiphoton lithography (MPL) is demonstrated, which enables full temporal control with nearly total freedom patterning design. Using MPL, 2D...

Abstract Background Renewable materials made using environmentally friendly processes are in high demand as a solution to reduce the pollution created by fashion industry. In recent years, there has been growing trend research on renewable focused bio-based derived from fungi. Results Recently, fungal cell wall material of chitosan producing fungus wet spun monofilaments. This paper presents modification for monofilament spinning process, development benign method, dry gel spinning, produce...

Characterization of amyloid-like aggregates through converging approaches can yield deeper understanding their complex self-assembly mechanisms and the nature strong mechanical stability, which may in turn contribute to design novel supramolecular peptide nanostructures as functional materials. In this study, we investigated coassembly kinetics oppositely charged short amyloid-inspired peptides (AIPs) into by using confocal fluorescence imaging thioflavin T binding, turbidity assay situ...

The fabrication of reusable, sustainable adsorbents from low-cost, renewable resources via energy efficient methods is challenging. This paper presents wet-stable, carboxymethylated cellulose nanofibril (CNF) and amyloid (ANF) based aerogel-like prepared through green processes for the removal metal ions dyes water. aerogels exhibit tunable densities (18–28 kg m–3), wet resilience, an interconnected porous structure (99% porosity), with a pH controllable surface charge adsorption both...

Peptide nanomaterials have received a great deal of interest in drug-delivery applications due to their biodegradability, biocompatibility, suitability for large-scale synthesis, high drug-loading capacities, targeting ability, and ordered structural organization. The covalent conjugation drugs peptide backbones results prolonged circulation time improved stability drugs. Therapeutic efficacy gemcitabine, which is used breast cancer treatment, severely compromised its rapid plasma...

Peptide–polymer nanofibrous networks can be developed to obtain hybrid systems providing both functionalities of peptides and stability processability the polymers. In this work, a bio-inspired heavy metal binding peptide was synthesized noncovalently immobilized on water-insoluble electrospun hydroxypropyl-beta-cyclodextrin nanofibers (CDNF). The functionalized were able bind ions facilitated removal from water. peptide–polymer scavenging system has potential for development further...

The successful buildup of biomimetic supramolecular multilayered nanobiomaterials comprising high-molecularweight alginate biopolymer and low-molecular-weight selfassembling peptide amphiphile is reported by João Borges, F. Mano, co-workers in article number 1605122, through combination self-assembly a layer-by-layer approach. amphiphile-ending nanostructures demonstrate to be privileged environment for cells, constituting promising nanoplatforms biomedical healthcare applications.