A5101897450- Amyloidosis: Diagnosis, Treatment, Outcomes
- Natural Language Processing Techniques
- Cardiovascular Function and Risk Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Sepsis Diagnosis and Treatment
- Platelet Disorders and Treatments
- Cardiomyopathy and Myosin Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemodynamic Monitoring and Therapy
- Multimodal Machine Learning Applications
- Clinical Laboratory Practices and Quality Control
- Parathyroid Disorders and Treatments
- Meta-analysis and systematic reviews
- Pain Mechanisms and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- PARP inhibition in cancer therapy
- Healthcare Operations and Scheduling Optimization
- Cancer Immunotherapy and Biomarkers
- Genetics, Aging, and Longevity in Model Organisms
- Acupuncture Treatment Research Studies
- Topic Modeling
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
Shanghai Artificial Intelligence Laboratory
2024
ShangHai JiAi Genetics & IVF Institute
2024
Washington University in St. Louis
2017-2023
The University of Texas Southwestern Medical Center
2022-2023
Biogen (United States)
2014-2022
Harborview Medical Center
2021
University of Wisconsin–Madison
2019
University of South Florida
2012
Olive View-UCLA Medical Center
2012
The ancient mind and body healing methods of yoga recently sparked fervor in the scientific community as an alternative complementary means therapy. Since World Health Organization officially began promoting developing countries 1978, has been cited for its therapeutic potential widely recognized Western culture. However, increasing number people practice remedial purposes, researchers raise two important questions: 1) Is a valid management rehabilitation treatment modality? 2) What...
In the Phase 3 DEFINE study, delayed-release dimethyl fumarate (DMF) 240 mg twice (BID) and three times daily (TID) significantly reduced mean number of new or enlarging T2-hyperintense lesions gadolinium-enhancing (Gd+) lesion activity at 2 years in patients (MRI cohort; n = 540) with relapsing–remitting MS. The analyses described here expand on these results by considering additional MRI measures (number T1-hypointense lesions; volume T2-hyperintense, Gd+, brain atrophy), delineating time...
Alcohol consumption synergistically increases the risk and severity of liver damage in obese patients. To gain insight into cellular or molecular mechanisms underlying development fatty caused by ethanol-obesity synergism, we have carried out animal experiments that examine effects ethanol administration genetically mice. Lean wild-type (WT) (ob/ob) mice were subjected to feeding for 4 wk using a modified Lieber-DeCarli diet. After feeding, ob/ob displayed much more pronounced changes terms...
The popularity of pre-trained large models has revolutionized downstream tasks across diverse fields, such as language, vision, and multi-modality. To minimize the adaption cost for tasks, many Parameter-Efficient Fine-Tuning (PEFT) techniques are proposed language 2D image models. However, specialized PEFT method 3D is still under-explored. this end, we introduce Point-PEFT, a novel framework adapting point cloud with minimal learnable parameters. Specifically, model, freeze most its...
Recently, Large Language Models (LLMs) and Multimodal (MLLMs) have shown promise in instruction following 2D image understanding. While these models are powerful, they not yet been developed to comprehend the more challenging 3D physical scenes, especially when it comes sparse outdoor LiDAR data. In this paper, we introduce LiDAR-LLM, which takes raw data as input harnesses remarkable reasoning capabilities of LLMs gain a comprehensive understanding scenes. The central insight our LiDAR-LLM...
There is a clinically unmet need for effective treatments triple-negative breast cancer (TNBC), as it remains the most aggressive subtype of cancer. Herein, we demonstrate promising strategy using tumor-targeting alkylphosphocholine (NM600) targeted radionuclide therapy TNBC. Methods: NM600 was radiolabeled with 86Y PET imaging and 177Lu therapy. 86Y-NM600 performed on female BALB/C mice bearing syngeneic 4T07 (nonmetastatic) 4T1 (metastatic) TNBC tumor grafts (n = 3-5). Quantitative data...
Abstract Background Intravenous (IV) fluid contamination is a common cause of preanalytical error that can delay or misguide treatment decisions, leading to patient harm. Current approaches for detecting rely on delta checks, which require prior result, manual technologist intervention, inefficient and vulnerable human error. Supervised machine learning may provide means detect contamination, but its implementation hindered by reliance expert-labeled training data. An automated approach...
Pain from rib fractures is associated with significant pulmonary morbidity. Epidural and paravertebral blocks (EPVBs) have been recommended as part of a multimodal approach to fracture pain, but their utility often challenging in the trauma intensive care unit (ICU). The serratus anterior plane block (SAPB) has potential an alternative for chest wall analgesia.This retrospective study compared critically injured adults sustaining multiple who had SAPB (n=14) EPVB (n=25). Patients were...
Due to accuracy concerns, the Food and Drug Administration issued guidances manufacturers that resulted in Center for Medicare Medicaid Services stating use of meters critically ill patients is "off-label" constitutes "high complexity" testing. This causing significant workflow problems ICUs nationally. We wished determine whether real-world modern glucose worse ICU compared with non-ICU inpatients.We reviewed results over preceding 3 years, comparing from paired meter central laboratory...
Abstract Polarization of the mammalian embryo at right developmental time is critical for its development to term and would be valuable in assessing potential human embryos. However, tracking polarization requires invasive fluorescence staining, impermissible vitro fertilization clinic. Here, we report use artificial intelligence detect from unstained time-lapse movies mouse We assembled a dataset bright-field movie frames 8-cell-stage embryos, side-by-side with corresponding images...
Key Points HLA-DRB1*03:01-DQB1*02:01 haplotype patients develop higher anti–platelet factor 4/heparin (PF4/H) levels following IV heparin exposure. HLA-restricted antigen presentation may play a role in the formation of anti-PF4/H antibodies.
Abstract Background The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patient samples is critical importance the management patients and monitoring transmission population. However, data on analytical performance characteristics for SARS-CoV-2 clinical specimens between individual targets within same platform, among different platforms, are limited. Methods Here we evaluated 6 sample-to-answer methods—Roche cobas 6800, Cepheid GeneXpert, Diasorin Simplexa,...
2607 Background: Both pembrolizumab and anthracyclines (AC) can cause adverse cardiovascular events; combination therapy is approved for high-risk, early-stage, triple-negative breast cancer (TNBC) may further increase real-world risk. Cardiac surveillance with serial troponin measurements has been advocated in this population, though evidence supporting approach lacking. Methods: High-sensitivity I (hs-TnI) was prospectively measured at baseline each treatment cycle patients receiving...
Abstract Background Therapeutic plasma exchange (TPE) utilizes an extracorporeal circuit to remove pathologic proteins causing serious illness. When processing a patient's entire blood volume through circuit, responsible for maintaining hemostatic system homeostasis can reach critically low levels if replacement fluid types and volumes are not carefully titrated, which may increase complications. Methods The charts from 27 patients undergoing 46 TPE procedures were reviewed evaluate the...
Objective: To present baseline data from initially enrolled participants in CHARM, a Phase 3 study evaluating whether intravenous (IV) glibenclamide (BIIB093) improves functional outcomes at 90 days individuals with large hemispheric infarction (LHI) compared placebo. Background: In preclinical models, reduces cerebral edema due to LHI by inhibiting the SUR1/TRPM4 cation channel. 2 trial suggested that placebo may reduce 30-day mortality and increase rates of favorable outcomes....
Abstract Laboratory testing is integral to the diagnosis and treatment of disease. Advances in electronic medical records computation have initiated an era ‘big data’ for laboratory medicine. However, most health data continues exist isolated inaccessible information silos, limiting public utility. To address this gap, we developed a large, de-identified, longitudinal dataset results from over one million patients, called Million Patient Labset (MPL), which free open public. The MPL was...
The burgeoning field of Multimodal Large Language Models (MLLMs) has exhibited remarkable performance in diverse tasks such as captioning, commonsense reasoning, and visual scene understanding. However, the deployment these large-scale MLLMs on client devices is hindered by their extensive model parameters, leading to a notable decline generalization capabilities when models are compressed for device deployment. Addressing this challenge, we introduce Cloud-Device Collaborative Continual...