A5091615543- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Veterinary Practice and Education Studies
- Nosocomial Infections in ICU
- Bacterial Infections and Vaccines
- Orthopedic Infections and Treatments
- Ear Surgery and Otitis Media
- Infection Control in Healthcare
- Family and Patient Care in Intensive Care Units
- Leptospirosis research and findings
- Brucella: diagnosis, epidemiology, treatment
- Infectious Diseases and Tuberculosis
- Bacterial biofilms and quorum sensing
- Zoonotic diseases and public health
- Pharmaceutical Practices and Patient Outcomes
- Emergency and Acute Care Studies
- Bacterial Identification and Susceptibility Testing
- COVID-19 Impact on Reproduction
- Agriculture and Farm Safety
- Human-Animal Interaction Studies
- Infection Control and Ventilation
- Clinical Reasoning and Diagnostic Skills
- Rabies epidemiology and control
The University of Queensland
2018-2024
Sunshine Coast University Hospital
2017-2024
Queensland Health
2020-2023
Institute of Infection and Immunity
2018
The University of Sydney
2018
The University of Melbourne
2018
Hunter New England Local Health District
2018
James Cook University
2018
Sullivan Nicolaides Pathology
2018
Toowoomba Hospital
2018
In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These led the inclusion of dose optimization recommendations international clinical practice guidelines. The last survey describing dosing, administration and monitoring commonly prescribed antibiotics for critically ill was published 2015 (ADMIN-ICU 2015). This study aimed describe evolution since this time.
Sepsis bundles, promulgated by Surviving Campaign have not been widely adopted because of variability in sepsis identification strategies, implementation challenges, concerns about excess antimicrobial use, and limited evidence benefit.A 1-hour septic shock a 3-hour bundle were implemented using Breakthrough Series Collaborative 14 public hospitals Queensland, Australia. A before (baseline) after (post-intervention) study evaluated its impact on outcomes prescription patients with confirmed...
Therapeutic drug monitoring (TDM) is an effective method for individualising antimicrobial therapy in critically ill patients. The 2021 ADMIN-intensive care unit survey studied a wide range of intensive clinicians worldwide to gain their perspectives on TDM. This article reports the responses from this relating TDM access, utilisation, and barriers.
BRUCELLOSIS IS A DISEASE caused by the intracellular, Gram-negative bacteria, Brucella species.Numerous species and biotypes (biovars) have been identified, but most important ones from human health perspective are: .abortus
We report the first case of COVID-19 in a pregnant patient with cystic fibrosis. describe diagnosis, clinical course and management their family regards to clinical, social infection control measures around delivery. This highlights importance cooperation multidisciplinary teams achieve good outcomes complex patients COVID-19.
Staphylococcus schleiferi bacteremia is an underappreciated cause of septic shock in the critical care department. Although nominally a coagulase variable and associated with otitis externa infections canine species, it has been metastatic infection including osteomyelitis, endocarditis, nephritis, meningitis humans. This report records possible zoonotic case S . subspecies coagulans following endovascular precipitating intensive admission for vasopressor support immunocompetent male.
This study aimed to compare the achievement of pharmacokinetic-pharmacodynamic (PK-PD) exposure targets for vancomycin using a newly developed dosing guideline with product-information-based in treatment adult patients serious infections.In silico product-information- and guideline-based simulations were performed across range doses patient characteristics, including body weight, age, renal function at 36-48 96 hours, pharmacokinetic model derived from seriously ill population. The median...
Abstract Study Objective The aim of this study was to compare the achievement therapeutic pharmacokinetic–pharmacodynamic (PK‐PD) exposure targets for beta‐lactam antibiotics using product information dosing or guideline‐based treatment serious infections. Design In silico study. Data Source ID‐ODS TM (Individually Designed Optimum Dosing Strategies). Patients and Intervention None. Measurements Main Results simulations cefepime, ceftazidime, flucloxacillin, meropenem,...
To determine if the introduction of an emergency department (ED) sepsis screening tool and management bundle affects antibiotic prescribing use.Multicentre, cohort, before-and-after study design.Three tertiary hospitals in Queensland, Australia (median bed size 543, range 520-742).Adult patients, presenting to ED with symptoms signs suggestive who had blood cultures collected. These participants were further assessed stratified as having septic shock, or infection alone, using Sepsis-3...
Background Managing risk effectively within small animal veterinary practice is integral for staff, patient and client safety. Veterinary personnel are exposed to many risks, including bites, scratches, sharps injuries exposure zoonotic diseases multi-resistant organisms. Patients may also be healthcare-associated infections, While owners/managers have a duty of care under legislated Workplace Health Safety requirements, all staff responsibility contribute assessing minimizing risk. The...
Background: Implementing 1-hour and 3-hour sepsis bundles for patients presenting with bacteraemia to public hospital emergency departments in the State of Queensland resulted improved bundle compliance a reduced need ICU admission post-implementation phase as compared baseline. Detailed investigation impact implementation on antibiotic prescribing has not previously been reported.Methods: A nested cohort study three hospitals evaluating prescription. The primary outcome was adherence...