A5103117305- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Neonatal Respiratory Health Research
- Pituitary Gland Disorders and Treatments
- Circadian rhythm and melatonin
- Ocular Oncology and Treatments
- Corneal surgery and disorders
- Neonatal and fetal brain pathology
- Glaucoma and retinal disorders
University of Pennsylvania
2016-2019
Penn Presbyterian Medical Center
2016
The pathophysiology of refractive errors is poorly understood. Myopia (nearsightedness) in particular both blurs vision and predisposes the eye to many blinding diseases during adulthood. Based on past findings diurnal variations dimensions eyes humans other vertebrates, altered rhythms these ocular with experimentally induced myopia, evolving evidence that ambient light exposures influence development, we assessed whether disturbances circadian signals might alter development eye. In mice,...
Purpose: The hypothesis that outdoor exposure might protect against myopia has generated much interest, although available data find only modest clinical efficacy. We tested the effect of rearing on form-deprivation in chicks, a model markedly inhibited by high-intensity indoor laboratory lighting. Methods: Unilaterally goggled cohorts White Leghorn chicks were maintained species-appropriate, rural setting during daylight hours to extent permitted weather. Control reared indoors with...
To determine whether there is a measurable change in hyperopia children with accommodative esotropia over time.A retrospective cohort of fully or partially diagnosed by age 7 years, followed to 10 older, and at least two cycloplegic refractions, one before years after years. The annual was calculated from linear mixed-effect models, overall during periods subgroup analysis baseline refractive error (<4D, ≥4D) type (partial, full) esotropia.405 subjects were studied. Mean first last visit 3.2...