A5009605360- Ophthalmology and Visual Impairment Studies
- Retinal Development and Disorders
- Corneal surgery and disorders
- Circadian rhythm and melatonin
- Retinopathy of Prematurity Studies
- Spaceflight effects on biology
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Visual perception and processing mechanisms
- Traditional Chinese Medicine Studies
- Glycosylation and Glycoproteins Research
- Advanced Fluorescence Microscopy Techniques
- Pharmacological Effects of Natural Compounds
- Ocular and Laser Science Research
- Intraocular Surgery and Lenses
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Down syndrome and intellectual disability research
- Hearing, Cochlea, Tinnitus, Genetics
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Retinal and Optic Conditions
- Ophthalmology and Visual Health Research
- Ubiquitin and proteasome pathways
- Advanced Optical Imaging Technologies
National Institutes of Health
2022-2024
Atlanta VA Health Care System
2016-2021
Emory University
2015-2021
Veterans Health Administration
2018
Atlanta Medical Center
2017
Atlanta VA Medical Center
2015-2017
Cornell University
1985-1992
NewYork–Presbyterian Hospital
1992
Rockefeller University
1985
Memorial Sloan Kettering Cancer Center
1985
Purpose: Exposure to high-intensity or outdoor lighting has been shown decrease the severity of myopia in both human epidemiological studies and animal models. Currently, it is not fully understood how light interacts with visual signaling impact myopia. Previous work performed mouse retina demonstrated that functional rod photoreceptors are needed develop experimentally-induced myopia, alluding an essential role for refractive development. Methods: To determine whether dim rod-dominated...
Experimental myopia in animal models suggests that bright light can influence refractive error and prevent myopia. Additionally, research indicates activation of rod pathways circadian rhythms may eye growth. In children, objective measures personal exposure, recorded by wearable sensors, have been used to examine the effects exposure on The effect time spent a broad range intensities childhood development is not known. This study aims evaluate dim myopia.We reanalyzed previously published...
Purpose: Exposure to short-wavelength light influences refractive development and inhibits myopic in many animal models. Retinal mechanisms underlying this response remain unknown. This study used a mouse model of lens-induced myopia evaluate the effect different wavelength on dopamine levels retina. A possible retinal pathway is tested using mutant with dysfunctional cones. Methods: Wild-type C57BL/6J (WT) ALS/LtJ/Gnat2cpfl3 (Gnat2−/−) mice were exposed one three conditions beginning at...
The pathophysiology of refractive errors is poorly understood. Myopia (nearsightedness) in particular both blurs vision and predisposes the eye to many blinding diseases during adulthood. Based on past findings diurnal variations dimensions eyes humans other vertebrates, altered rhythms these ocular with experimentally induced myopia, evolving evidence that ambient light exposures influence development, we assessed whether disturbances circadian signals might alter development eye. In mice,...
The neuromodulator dopamine (DA) has been implicated in the prevention of excessive ocular elongation and myopia various animal models. This study used retina-specific DA knockout mice to investigate role retinal refractive development susceptibility experimental myopia.Measurements error, corneal curvature, biometrics were obtained as a function age for both untreated form-deprived (FD) groups tyrosine hydroxylase (rTHKO) control (Ctrl) mice. Retinas from each group analyzed by HPLC levels...
Purpose: We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. hypothesized this protective effect varies with intensity. To test this, mice undergoing LIRD were run at different speeds and function was assessed. Methods: BALB/c assigned to groups varying speeds—0, 5, 10, or 20 m/min labeled inactive, low, medium, high, respectively—and compared naïve exposed standard lighting (50 lux; naïve). Following 2...
O1 Changes in peripheral refraction associated with decreased ocular axial growth rate marmosets Alexandra Benavente-Perez, Ann Nour, Tobin Ansel, Kathleen Abarr, Luying Yan, Keisha Roden, David Troilo O2 PPARα activation suppresses myopia development by increasing scleral collagen synthesis--a new drug target to suppress Chanyi Lu, Miaozhen Pan, Min Zheng, Jia Qu, Xiangtian Zhou O3 Evidence and possibilities for local regulating signal pathways Christine F Wildsoet O4 Myopia researches at...