A5009240573- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Advanced Glycation End Products research
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Neuroscience of respiration and sleep
- Microtubule and mitosis dynamics
- Nitric Oxide and Endothelin Effects
- Cellular Mechanics and Interactions
- Bone and Dental Protein Studies
- S100 Proteins and Annexins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Microbial metabolism and enzyme function
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
Institute of Science and Technology Austria
2024
Universidad Autónoma de Madrid
2015-2023
Hospital Universitario de La Princesa
2016-2020
Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is involved the maintenance of lung homeostasis. New work identified a role for TSP1 promoting PAH. Nonetheless, it largely unknown how hypoxia regulates whether this contributes to pathological events during PAH.In cell animal experiments, we found that induces lungs, artery smooth muscle cells endothelial...
Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1−/− mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1–CD47 axis upregulated in human PH promotes arterial vasculopathy. analyzed molecular signature functional response of lung tissue distal arteries (PAs) individuals with (n = 23) without 16) PH. Compared controls, lungs PAs patients showed induction endothelin-1/endothelin A receptor (ET-1/ETA) protein mRNA. In control PAs, treatment exogenous TSP1 inhibited...
Abstract Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing form localization, this affects organization shape remains unclear. Here we show that in ascidian oocytes, cooperative activities actomyosin deformation mitochondria-rich myoplasm drive oocyte reorganization changes following fertilization. We vegetal-directed...
Vascular cell adhesion molecule 1 (VCAM-1) is an assigned to the activated endothelium mediating immune cells and extravasation. However, its expression in renal carcinomas inversely correlates with tumor malignancy. Our experiments clear carcinoma (ccRCC) lines demonstrated that von Hippel Lindau (VHL) loss, hypoxia, or PHD (for prolyl hydroxylase domain-containing proteins) inactivation decreased VCAM-1 levels through a transcriptional mechanism was independent of hypoxia-inducible factor...
Rationale: Cigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on progressive deterioration airways has been extensively studied, but its direct effects vasculature are less known. Objectives: To prove that arterial remodeling in patients with COPD not just a consequence alveolar hypoxia also due to cigarette vascular bed. Methods: We have used different molecular and cell biology approaches, as well traction force microscopy,...
Abstract Thrombospondin-1 (TSP-1) is a multifunctional matrix protein with antitumor activities due in part to its ability inhibit angiogenesis, which turn contributes determine the fate of many tumours. Previous studies have shown that TSP-1 expression supports normal kidney angiostasis, and decreased levels contribute angiogenic phenotype renal cell carcinomas (RCC). The loss von Hippel-Lindau tumour suppressor gene ( VHL ) these tumours favours stabilization Hypoxia Inducible Factors...
Abstract Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no curative therapies nowadays. Exposure to cigarette smoking considered the chief leading cause of COPD. Current drugs improve patient quality life, however they do not revert progression disease. Therefore, deeper study cellular and molecular mechanisms that underlie this pathology required be able carry out targeted effective treatments. Although effects smoke in progressive deterioration airway have been...
Smoking is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on progressive deterioration airways has been extensively studied. However, its direct effects vasculature have not studied in deep, part due to classic conception that vascular damage a consequence alveolar hypoxia and loss capillary bed. We used different molecular cell biology approaches, as well tissue studies from vivo models human samples analyse how cigarette smoke extract (CSE)...
Smoking is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on progressive deterioration airways has been extensively studied. However, its direct effects vasculature have not studied in deep, part due to classic conception that vascular damage a consequence alveolar hypoxia and loss capillary bed. We used different molecular cell biology approaches, as well tissue studies from vivo models human samples analyse how cigarette smoke extract (CSE)...