A5006467807- Pharmacological Effects of Medicinal Plants
- Protein Degradation and Inhibitors
- Bone Metabolism and Diseases
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
University of Göttingen
2020-2023
Abstract Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% all DIPG characterized by a lysine-to-methionine substitution histone 3, which leads to global H3K27 hypomethylation accompanied hyperacetylation. Hyperacetylation favors action Bromodomain and Extra-Terminal (BET) protein BRD4, reprogramming enhancer landscape contributing activation super enhancer-driven oncogenes. The activity...
Pediatric high-grade gliomas (pedHGG) comprise a very poor prognosis. Thus, parents of affected children are increasingly resorting to complementary and alternative medicine (CAM), among those Boswellia extracts. However, nothing is known about the therapeutic effectiveness their active substances, Boswellic acids (BA) in pedHGG. we aimed investigate if three main present plants, alpha-boswellic acid (α-BA), beta-boswellic (β-BA) 3-acetyl-11-keto-beta-boswellic (AKBA) hold any promising...