A5058370509- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Advanced Glycation End Products research
- Mechanical stress and fatigue analysis
- Metallurgy and Material Forming
- Tryptophan and brain disorders
- Library Science and Information Systems
- Diet, Metabolism, and Disease
- Antimicrobial Peptides and Activities
- Vitamin C and Antioxidants Research
- Renal Transplantation Outcomes and Treatments
- Hip and Femur Fractures
- Organ Transplantation Techniques and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- Redox biology and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Animal testing and alternatives
- Heme Oxygenase-1 and Carbon Monoxide
University of Alabama at Birmingham
2014-2024
St. Vincent's Birmingham
2020
Department of Physiological Sciences
1958
Acute lung injury (ALI) is characterized by exuberant proinflammatory responses and mitochondrial dysfunction. However, the link between dysfunction inflammation in ALI not well understood. In this report, we demonstrate a critical role for NAD+-dependent deacetylase, sirtuin-3 (SIRT3), regulating macrophage bioenergetics, ROS formation, responses. We found that SIRT3 expression was significantly diminished lungs of mice subjected to LPS-induced ALI. SIRT3-deficient (SIRT3-/-) develop more...
Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious prolonged respiratory complications survivors. Given that endoplasmic reticulum (ER) stress is a hallmark sepsis-related alveolar epithelial cell (AEC) dysfunction, we tested if AMP-activated protein kinase (AMPK) affects recovery from ER apoptosis AECs during post-bacterial infection.
Abstract Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK Parkin ubiquitin ligase are known regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it not if this evolutionarily conserved mechanism has been coopted by the host defense eradicate pathogens influence post-sepsis immunosuppression. Parkin, levels, effects activators were investigated in human leukocytes from...
Trauma and sepsis are frequent causes of immunosuppression risk secondary bacterial infections mortality among critically ill patients. Reduced activity neutrophil NADPH oxidase 2 (NOX2) impaired killing the major indices immunosuppression. We hypothesize that NOX2-decoy peptides disrupt inhibition NOX2 by plasma patients with severe trauma immunosuppression, thereby preserving respiratory burst is a central antimicrobial mechanism. demonstrate from trauma/hemorrhage (T/H) patients, but not...
Background : Trauma and blood loss are frequently associated with organ failure, immune dysfunction, a high risk of secondary bacterial lung infections. We aim to test if plasma metabolomic flux monocyte bioenergetics altered in association trauma related Methods Plasma samples were collected from patients at three time points: days 0, 3, 7 postadmission. Metabolites (140) measured survivors ( n = 24) healthy control individuals (HC, 10). Further analysis within the cohort included subsets...
Abstract The earliest phases of humoral defense are orchestrated by splenic marginal zone (MZ) and body cavity-derived B1 B cells. These frontline responders have been termed “innate-like” given their broadly-reactive natural antibody repertoires capacity for rapid responses to T cell-independent (TI) antigens. Despite key contributions primary responses, why these cells possess such prompt responsivity innate-stimulation is poorly understood. discovery a family Fc receptor-like (FCRL)...
Abstract At homeostasis and during primary responses to pathogens, humoral host defense is chiefly coordinated by body cavity-derived B-1 splenic marginal zone (MZ) B cells. These early responders have been termed “innate-like” due their broadly-reactive natural antibody repertoires rapid T cell-independent (TI) antigens. However, what regulates these functions in specialized cells remains unclear. Fc receptor-like (FCRL) molecules homology the classical FCRs for IgG IgE, exhibit complex...
Abstract Background Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious prolonged respiratory complications survivors. Given that endoplasmic reticulum (ER) stress is a hallmark sepsis-related alveolar epithelial cell (AEC) dysfunction, we tested if AMP-activated protein kinase (AMPK) affects recovery from ER apoptosis AECs during post-bacterial infection. Methods In murine model by P. aeruginosa...