A5012045807- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Systemic Lupus Erythematosus Research
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Bone and Joint Diseases
- Protease and Inhibitor Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Medical and Biological Sciences
- Immune Cell Function and Interaction
- Skin Diseases and Diabetes
- Spine and Intervertebral Disc Pathology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chemokine receptors and signaling
- Orthopedic Infections and Treatments
Institute of Rheumatology
2014-2024
Charles University
2004-2024
Centre Hospitalier Universitaire de Besançon
2023
Inserm
2023
<h3>Background</h3> Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression joint structure and symptom changes in knee osteoarthritis, as previously suggested. <h3>Methods</h3> Two hundred two patients (using American College Rheumatology criteria) were randomized receive oral sulfate, 1500...
Objective To investigate the effect of glucosamine sulfate on long-term symptoms and structure progression in postmenopausal women with knee osteoarthritis (OA). Design This study consisted a preplanned combination two three-year, randomized, placebo-controlled, prospective, independent studies evaluating modification OA post-hoc analysis results obtained OA. Minimal joint space width was assessed at baseline after 3 years from standing anteroposterior radiographs. Symptoms were scored by...
Dickkopf-1 (DKK-1) is an inhibitor of osteoblastogenesis, and its lower levels are linked to new bone formation. The aim this study was therefore explore serum DKK-1 evaluate DKK-1's association with the severity spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH).Serum total functional C-reactive protein (CRP) were measured 37 patients DISH 22 healthy age sex-matched controls. Plain radiographs cervical thoracic spine performed, diagnosis defined using Resnick criteria....
Summary The aim of the study was to examine relation between polymorphisms and serum levels selected cytokines ( IL ‐6, ‐13 ‐15), production autoantibodies factors describing rheumatoid arthritis RA ), such as DAS 28 Total Sharp Score. A total 156 patients with according ACR criteria, 200 control subjects were recruited into study. measurements CRP , anti‐ CCP presence RF s), radiographs both hands calculation Score TSS ) obtained from all . In total, five in genes coding ‐15) detected....
Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from disease-affected tissue. We investigated whether were associated with disease activity and could distinguish non-radiographic(nr)-axSpA ankylosing spondylitis (AS). A total 193 axSpA patients (nr-axSpA, n = 121 AS, 72) asymptomatic controls (n 100) included. Serum levels metalloproteinase (MMP)-degraded type I (C1M), II (C2M), III (C3M) IV (C4M2) quantified by enzyme-linked immunosorbent...
Objective This study compared demographic, clinical and laboratory characteristics between patients with radiographic non-radiographic axial spondyloarthritis (axSpA). Methods In this single-centre cross-sectional study, a total of 246 axSpA fulfilling the imaging arm Assessment SpondyloArthritis International Society classification criteria were recruited. A 140 diagnosed as (nr-axSpA), 106 had ankylosing spondylitis (AS). Sociodemographic characteristics, disease manifestations, activity...
Abstract : Matrix metalloproteinases (MMPs) as a family of zinc‐dependent endopeptidases have been involved in remodeling the extracellular matrix (ECM) rheumatoid arthritis (RA). In RA patients synovial fluid and serum include enhanced levels MMP‐3. The 5A/6A polymorphism MMP‐3 gene promoter can contribute to severity on account higher activity 5A allele vitro . aim study was associate with radiographic progression RA. A total 128 according ACR criteria were available for study. Radiographs...
The aim of study was to examine relationship among levels cytokines (IL-6, IL-13, IL-15, TNF-α) and chemokine (IL-8), production autoantibodies, radiographic progression, factors describing rheumatoid arthritis (RA). A total 156 RA patients according ACR criteria, 55 control subjects were recruited into study. We observed higher IL-15 within compared healthy controls. Correlations cytokine the measures factors, anti-CCP, disease activity, progression observed. conclude that level in...