Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity.In the current study, we investigated whether calprotectin is better than CRP for predicting clinical activity and ultrasound parameters in patients with RA.A total 160 RA underwent (swollen joint count-SJC, tender count-TJC, Disease Activity Score-DAS28, Clinical Index-CDAI, simplified Index-SDAI) (German US7) examination. laboratory measures were correlated findings using Spearman´s correlation...

Objective Interleukin (IL)-40 is a new cytokine related to immune system function and malignancies. Recently, an association of IL-40 with rheumatoid arthritis (RA) externalisation neutrophil extracellular traps (NETosis) was found. As neutrophils are implicated in RA development, we investigated early stages (ERA). Methods determined serum treatment naïve patients ERA at baseline (n=60) 3 months after initiation conventional therapy healthy controls (HC; n=60). Levels IL-40, cytokines...

Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It unknown, whether extent synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for functioning. To answer this question we investigated longitudinal relationship between function assessed health assessment questionnaire (HAQ) and German 7-joint score (US7S) prospective cohort patients with RA. Patients RA (n = 185 (46 incident...

The aims of this study were to analyse the serum concentrations clusterin (CLU) in patients with hand osteoarthritis (OA) and healthy controls, compare CLU levels between erosive non-erosive disease, examine association clinical laboratory parameters.A total 135 OA (81 54 disease) 53 individuals included study. All underwent joint ultrasound examination. Australian/Canadian (AUSCAN) index, algofunctional index a visual analogue scale (VAS) for measurement pain assessed. Serum measured by an...

Interleukin-21 (IL-21) plays an important role in the pathogenesis of rheumatoid arthritis (RA). The aim our study was to assess serum levels IL-21 patients with recent-onset RA relation disease activity and response treatment. We analyzed 51 patients, both before 12 weeks after initiation treatment 36 healthy individuals. Disease assessed at baseline 24 using Activity Score for 28 joints, C-reactive protein, total swollen joint count. found that were not increased compared controls, but...

Objective Clinical remission in some patients with rheumatoid arthritis (RA) may be associated ongoing synovial inflammation that is not always detectable on clinical examination or reflected by laboratory tests but can visualized musculoskeletal ultrasound. The goal of our study was to determine the levels serum calprotectin, a major leukocyte protein, RA and investigate ability calprotectin distinguish ultrasound-defined from those residual ultrasound subclinical inflammation. Methods...

Abstract Clusterin (CLU) is a molecular chaperone that participates in variety of biological processes. Recent studies indicate its possible involvement the development bone erosions and autoimmunity. The aim this study was to investigate serum concentrations patients with early rheumatoid arthritis (RA) explore their potential relationship disease activity treatment response. Serum levels CLU were measured 52 before 3 months after initiation healthy individuals. at baseline significantly...

Background: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be main source. To verify involvement in HOA pathogenesis, we evaluate serum inflammatory mediators their association with HOA-related clinical features patients. Methods: 153 participants (50 non-erosive patients, 54 49 healthy control subjects) were included this study. All patients underwent examination, which assessment tender swollen small...

<h3>Background:</h3> Cartilage Acidic Protein (CRTAC1) is a chondrocyte-produced protein associated with osteoarthritis (OA) pathophysiology. Elevated levels of CRTAC1 were observed in both cartilage and plasma samples from OA patients can potentially predict occurrence or progression to joint replacement. <h3>Objectives:</h3> This study aims compare synovial fluid (SF) collected diagnosed knee rheumatoid arthritis (RA) comparison unpaired healthy controls (HCs). Secondly, it explore the...

<h3>Background:</h3> There are many effective treatment options for rheumatoid arthritis (RA), but relatively less evidence to support the use of any one bDMARD or drug class over another. Further research is needed, as well rigorous analysis data from real-world clinical practice, determine whether specific subgroups patients may benefit drug. <h3>Objectives:</h3> The aim this study was compare results with RA etanercept versus monoclonal anti-TNF inhibitors (TNFi) initiating first-line...

<h3>Background</h3> Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA heterogeneous group disorders with two main subsets including non-erosive erosive disease. Few studies demonstrated inflammatory ultrasound changes more severe clinical symptoms in patients compared disease, however the results are inconsistent. <h3>Objectives</h3> The aim this study was to evaluate progression pain, stiffness, physical impairment features three years longitudinal study....

<h3>Background</h3> It has been shown that patients in remission of rheumatoid arthritis (RA) continue to have subclinical synovitis¹. <h3>Objectives</h3> To evaluate the usefulness US7 scoring system detecting synovitis with RA who are disease. <h3>Methods</h3> 73 according DAS 28 &lt;2.6 criteria duration at least 3 months were identified. ACR/EULAR assessed separately. HAQ, SJC, and TJC evaluated during 1 year intervals. The 7-joint ultrasound score (US7) was used for all US...

<h3>Background</h3> Wilsone disease (WD) is an autosomal recessive hereditary metabolic disorder leading to the pathologic accumulation of copper in various organs, especially brain and liver. The most frequent clinical manifestations consist liver form neurological-psychiatric form. Problems with joints are common affect a high percentage patients suffering from WD. Joint involvement WD has not been studied details so far. Treatment very effective. One approach involves treatment...

<h3>Background</h3> Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain morbidity. Some metabolic factors were suggested to be implicated in disease. Few studies investigated differences systemic bone loss between non-erosive OA. <h3>Objectives</h3> To compare the change mineral density (BMD) patients with a longitudinal study after three years. <h3>Methods</h3> American College Rheumatology (ACR) criteria used assess Erosive was defined by at least...

Background: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit protein translation and therefore essential for several physiological pathological functions. miRNAs regulate up to 60 % human mRNA, including genes related cartilage development, homeostasis, OA pathology. For example, miR-9 inhibits matrix metalloproteinase 13 miR-140 expression level correlates with disease progression knee (Zhang et al.; Chao al.). Under certain circumstances, be...

<h3>Background</h3> Hand osteoarthritis (OA) and its severe subset erosive hand OA are common causes of pain morbidity in western world. Few studies investigated differences systemic bone loss metabolic diseases between non-erosive OA. <h3>Objectives</h3> To compare mineral density risk factors patients with a cross-sectional study. <h3>Methods</h3> Patients symptomatic disease fulfilling the American College Rheumatology (ACR) criteria for were included this Erosive was defined by at least...

<h3>Background</h3> The name of carpal tunnel syndrome (CTS) refers to a complex symptoms resulting from the pressure exerted on median nerve in area. CTS is most frequent neuropathy. treatment chronic neuropathic pain or mixed states neuropathic-inflammatory difficult. conservative treatments that currently exist are only moderately effectively. Oral pharmaceuticals for have significant side effects, and efficacy tends be modest. use topical analgesics reduces potential systemic effects...

<h3>Background</h3> Calprotectin, a heterodimeric complex of S100A8/9 (MRP8/14), has been demonstrated as an important biomarker clinical and laboratory disease activity structural joint damage in rheumatoid arthritis (RA).^1,2 Ultrasound is sensitive reliable tool for assessing synovial inflammation RA.³ <h3>Objectives</h3> To test the hypothesis that calprotectin associated with ultrasound patients RA cross-sectional study to investigate contribution various parameters...

<h3>Background</h3> Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain morbidity. Some metabolic factors were suggested to be implicated in disease. Furthermore, few studies investigated differences systemic bone loss between non-erosive OA. <h3>Objectives</h3> To compare mineral density (BMD) major cardiovascular risk patients with a cross-sectional study. <h3>Methods</h3> Patients symptomatic disease fulfilling the American College Rheumatology...

<h3>Background</h3> Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA heterogeneous group disorders with two main subsets including non-erosive disease erosive, sometimes referred to as inflammatory, HOA. Few studies demonstrated inflammatory ultrasound changes more severe clinical symptoms in patients erosive compared disease, however the results are inconclusive. <h3>Objectives</h3> The aim study was compare pain, stiffness, physical impairment features between...

<h3>Objectives</h3> To investigate the longitudinal relationship between physical disability and US7S in a prospective cohort of patients with RA. <h3>Methods</h3> A 205 RA pts (49 incident/156 prevalent) (mean±SD age 55±14 years, 47% RF+, 63% ACPA+, DAS28-CRP 3.7±1.5, mHAQ 0.43±0.52, disease duration incident vs. prevalent pts. 0.9±0.7 8.1± 8.3 resp.) was followed up longitudinally for 29±9 months. Assessments at baseline month 3 6, then every 6 months comprised DAS28-CRP, functional...