A5048881704- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Osteoarthritis Treatment and Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Muscle Physiology and Disorders
- Clusterin in disease pathology
- Toxin Mechanisms and Immunotoxins
- Musculoskeletal Disorders and Rehabilitation
- Bone health and osteoporosis research
- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Bone health and treatments
- Renal function and acid-base balance
- Systemic Lupus Erythematosus Research
- Neurogenetic and Muscular Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Machine Learning in Bioinformatics
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
Charles University
2015-2024
Institute of Rheumatology
2015-2024
Complexo Hospitalario Universitario A Coruña
2021
Universidade da Coruña
2021
Stevenage Bioscience Catalyst
2021
Hospital Fatuma Bourguiba Monastir
2021
Instituto de Investigación Biomédica de A Coruña
2021
Center for Rheumatology
2017
Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity.In the current study, we investigated whether calprotectin is better than CRP for predicting clinical activity and ultrasound parameters in patients with RA.A total 160 RA underwent (swollen joint count-SJC, tender count-TJC, Disease Activity Score-DAS28, Clinical Index-CDAI, simplified Index-SDAI) (German US7) examination. laboratory measures were correlated findings using Spearman´s correlation...
Objective Interleukin (IL)-40 is a new cytokine related to immune system function and malignancies. Recently, an association of IL-40 with rheumatoid arthritis (RA) externalisation neutrophil extracellular traps (NETosis) was found. As neutrophils are implicated in RA development, we investigated early stages (ERA). Methods determined serum treatment naïve patients ERA at baseline (n=60) 3 months after initiation conventional therapy healthy controls (HC; n=60). Levels IL-40, cytokines...
Abstract Background The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation immune can be severely disabling. objective this study was to assess effect a 24-week program combining supervised training activities daily living (ADL), resistance, stability with home exercise for improving muscle function, compared home-based representing regular outpatient care. Methods Fifty-seven patients IIM were consecutively...
Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It unknown, whether extent synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for functioning. To answer this question we investigated longitudinal relationship between function assessed health assessment questionnaire (HAQ) and German 7-joint score (US7S) prospective cohort patients with RA. Patients RA (n = 185 (46 incident...
The aims of this study were to analyse the serum concentrations clusterin (CLU) in patients with hand osteoarthritis (OA) and healthy controls, compare CLU levels between erosive non-erosive disease, examine association clinical laboratory parameters.A total 135 OA (81 54 disease) 53 individuals included study. All underwent joint ultrasound examination. Australian/Canadian (AUSCAN) index, algofunctional index a visual analogue scale (VAS) for measurement pain assessed. Serum measured by an...
Interleukin-21 (IL-21) plays an important role in the pathogenesis of rheumatoid arthritis (RA). The aim our study was to assess serum levels IL-21 patients with recent-onset RA relation disease activity and response treatment. We analyzed 51 patients, both before 12 weeks after initiation treatment 36 healthy individuals. Disease assessed at baseline 24 using Activity Score for 28 joints, C-reactive protein, total swollen joint count. found that were not increased compared controls, but...
Objective Clinical remission in some patients with rheumatoid arthritis (RA) may be associated ongoing synovial inflammation that is not always detectable on clinical examination or reflected by laboratory tests but can visualized musculoskeletal ultrasound. The goal of our study was to determine the levels serum calprotectin, a major leukocyte protein, RA and investigate ability calprotectin distinguish ultrasound-defined from those residual ultrasound subclinical inflammation. Methods...
Abstract Clusterin (CLU) is a molecular chaperone that participates in variety of biological processes. Recent studies indicate its possible involvement the development bone erosions and autoimmunity. The aim this study was to investigate serum concentrations patients with early rheumatoid arthritis (RA) explore their potential relationship disease activity treatment response. Serum levels CLU were measured 52 before 3 months after initiation healthy individuals. at baseline significantly...
The aim of this study was to evaluate the role S100A4 as a biomarker in patients with early rheumatoid arthritis (RA). levels were measured 59 RA and 41 healthy controls. association between treatment outcome after 12 months determined using multivariate regression analysis. Serum significantly higher than subjects decreased 3 treatment. Diseases activity at female who had initially high S100A4. Persistently predicted poor may thus represent promising for assessing response RA.
Osteoporosis is characterized by low bone mineral density (BMD) and an increased risk of fracture. In randomized controlled trials, denosumab has been shown to significantly reduce the fracture in women with osteoporosis. However, little known about real-world management who are prescribed denosumab. This multicenter, prospective, observational study Czech Republic Slovakia evaluated baseline characteristics clinical postmenopausal osteoporosis for 24 months. A total 600 were included (300...
Background: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be main source. To verify involvement in HOA pathogenesis, we evaluate serum inflammatory mediators their association with HOA-related clinical features patients. Methods: 153 participants (50 non-erosive patients, 54 49 healthy control subjects) were included this study. All patients underwent examination, which assessment tender swollen small...
<h3>Background</h3> Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA heterogeneous group disorders with two main subsets including non-erosive erosive disease. Few studies demonstrated inflammatory ultrasound changes more severe clinical symptoms in patients compared disease, however the results are inconsistent. <h3>Objectives</h3> The aim this study was to evaluate progression pain, stiffness, physical impairment features three years longitudinal study....
Osteoporóza je onemocnění s masovým výskytem, postihující převážně starší populaci.V České republice osteoporóza postihuje 33 % žen a 15 mužů ve věku nad 50 let 47 39 70 let, celkově tedy více než 6 obyvatel.Riziko zlomeniny krčku stehenní kosti pro padesátiletou ženu 9-18%, padesátiletého muže 3-6%.20-30 pacientů, kteří utrpěli tuto zlomeninu, do roka umírá, 30-40 trvale odkázáno na pomoc jiných osob.Po zlomenině v oblasti kyčle u žen, stejně tak jako mužů, narůstá riziko úmrtí po této...
<h3>Background</h3> Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain morbidity. Some metabolic factors were suggested to be implicated in disease. Few studies investigated differences systemic bone loss between non-erosive OA. <h3>Objectives</h3> To compare the change mineral density (BMD) patients with a longitudinal study after three years. <h3>Methods</h3> American College Rheumatology (ACR) criteria used assess Erosive was defined by at least...
<h3>Background</h3> Idiopathic inflammatory myopathy are characterized by muscle weakness, caused inflammation and immune changes in the affected muscles, which lead to a limitation execution of day-to-day activities (ADL). The aim our study was investigate impact specialized intensive aDL training on strength endurance, depression QoL IIM patients. <h3>Objectives</h3> included total 50 patients who fulfilled Bohan Peter 1975 criteria had skeletal involvement. 27 were recruited into...
Background: Skeletal muscle, pulmonary and articular involvement in idiopathic inflammatory myopathies (IIM) limit the mobility/self-sufficiency of patients, can have a negative impact on body composition. Objectives: The aim was to assess composition physical activity IIM patients healthy controls (HC) association with selected cytokines/chemokines laboratory markers nutrition lipid metabolism. Methods: 54 (45 females; mean age 57.7; disease duration 5.8 years; polymyositis (PM, 22) /...
Background: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit protein translation and therefore essential for several physiological pathological functions. miRNAs regulate up to 60 % human mRNA, including genes related cartilage development, homeostasis, OA pathology. For example, miR-9 inhibits matrix metalloproteinase 13 miR-140 expression level correlates with disease progression knee (Zhang et al.; Chao al.). Under certain circumstances, be...
<h3>Background</h3> Hand osteoarthritis (OA) and its severe subset erosive hand OA are common causes of pain morbidity in western world. Few studies investigated differences systemic bone loss metabolic diseases between non-erosive OA. <h3>Objectives</h3> To compare mineral density risk factors patients with a cross-sectional study. <h3>Methods</h3> Patients symptomatic disease fulfilling the American College Rheumatology (ACR) criteria for were included this Erosive was defined by at least...