A5021144183- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Ergonomics and Musculoskeletal Disorders
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and disorders
- Genetic Syndromes and Imprinting
- Prostate Cancer Treatment and Research
- Musculoskeletal pain and rehabilitation
- Effects of Vibration on Health
- Cancer Research and Treatments
Union Hospital
2020-2024
Jilin University
2017-2024
First Bethune Hospital of Jilin University
2024
Union Hospital
2017-2020
United States Government Accountability Office
2001
Abstract Purpose This study aimed to explore novel tumor immune microenvironment (TIME)-associated biomarkers in prostate adenocarcinoma (PRAD). Methods PRAD RNA-sequencing data were obtained from UCSC Xena database as the training dataset. The ESTIMATE package was used evaluate stromal, immune, and purity scores. Differentially expressed genes (DEGs) related TIME screened using stromal Gene functions analyzed DAVID. LASSO method performed screen prognostic TIME-related genes. Kaplan–Meier...
Collagen triple helix repeat containing-1 (CTHRC1), a secreted glycoprotein, is frequently upregulated in human cancers. However, the functional role of CTHRC1 renal cell carcinoma (RCC) remains unclear. Thus, aim this study was to explore RCC. Our results demonstrated that RCC tissues and lines. Knockdown significantly inhibits proliferation RCCs. Furthermore, knockdown inhibited epithelial-to-mesenchymal transition (EMT) process RCCs, as well suppressed migration invasion. Mechanistically,...
MicroRNAs (miRNAs) have emerged as critical regulators in cancer progression. miR‑613 has been reported a tumor suppressor gene many types of human cancers. However, the function renal cell carcinoma (RCC) remains unclear. In present study, authors aimed to detect expression and its RCC lines. was be significantly downregulated Functional analyses demonstrated that overexpression decreased proliferation invasion. Bioinformatics analysis showed Frizzled7 (FZD7) predicted target miR‑613, which...
SUMMARY Using computer-aided engineering (CAE) in the concept design stage of automobiles has become a hotspot human factor research. Based on musculoskeletal biomechanical computational software, seated human-body model was built to describe natural sitting posture driver. The interaction between driver and car various combinations seat-pan/back-rest inclination angles analyzed using an inverse-dynamics approach. In order find out “most comfortable” driving seat-pan/back-rest, effect muscle...
Wilms tumor (WT) is an embryonic malignant tumor, and its related mechanism still unclear. microRNA (miR), as a short-chain non-coding RNA, has low expression in various tumors. In this study, WT differential miR was screened by multi-chip GEO database explored to provide potential therapeutic targets ideas for clinic.We logged into downloaded GSE57370 GSE48137 chip matrix files analyze differences miR. TargetScan, miRDB, miRTarBase starBase were applied predict the target genes of with...
Background Prostate cancer is one of the leading causes cancer-related deaths in men. Its molecular pathogenesis closely linked to various genetic and epigenetic alterations, including posttranslational modifications like SUMOylation. Identifying biomarkers that predict outcomes specific therapeutic targets depends on a comprehensive understanding these processes. With growing interest SUMOylation as mechanism affecting prostate genes, this study aimed investigate central role prognostics,...