A5001265397- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Biosimilars and Bioanalytical Methods
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
- Carbohydrate Chemistry and Synthesis
- Epigenetics and DNA Methylation
Wenzhou Medical University
2024
Huashan Hospital
2019-2024
Fudan University
2019-2024
Liaocheng University
2024
First Bethune Hospital of Jilin University
2024
Second Military Medical University
2015-2016
Non-small cell lung cancer (NSCLC) is the primary subtype of cancer. Long non-coding RNAs (lncRNAs) have been reported to serve prominent roles in progression. However, expression patterns and potential lncRNAs NSCLC remain be elucidated. In present study, four public datasets were analyzed identify differentially expressed (DElncs) NSCLC. A further dataset, GSE19188, was validate findings. total 38 upregulated 31 downregulated identified NSCLC, compared with samples from healthy controls....
Nivolumab is a therapeutic fully human IgG4 antibody to programmed death 1 (PD-1). In this study, nivolumab biosimilar, which was produced in our laboratory, analyzed and characterized. Sequence variants that contain undesired amino acid sequences may cause concern during biosimilar bioprocess development. We found low levels of sequence were detected the heavy chain by ultra performance liquid chromatography (UPLC) tandem mass spectrometry. It further identified with UPLC-MS/MS IdeS or...
Abstract The epigenetic remodeling of chromatin through histone modifications has been widely implicated in drug resistance cancer cells. However, whether mechanisms contribute specifically to doxorubicin leukemia not carefully examined. Using a stable and sensitive workflow based on LC‐MS, we quantitatively compared the extents methylation acetylation H3 H4 acute cell line HL60 its doxorubicin‐resistant derivative, HL60/ADR, as well chronic K562 K562/ADR. We found that increased levels H3K9...
Background Prostate cancer is one of the leading causes cancer-related deaths in men. Its molecular pathogenesis closely linked to various genetic and epigenetic alterations, including posttranslational modifications like SUMOylation. Identifying biomarkers that predict outcomes specific therapeutic targets depends on a comprehensive understanding these processes. With growing interest SUMOylation as mechanism affecting prostate genes, this study aimed investigate central role prognostics,...