A5026429211- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Morphological variations and asymmetry
- Neurological disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- 3D Shape Modeling and Analysis
- Image Retrieval and Classification Techniques
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Music Perception
- Matrix Theory and Algorithms
- Random Matrices and Applications
- Sparse and Compressive Sensing Techniques
- Mental Health Research Topics
- Medical Imaging Techniques and Applications
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Cognitive Abilities and Testing
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Botulinum Toxin and Related Neurological Disorders
Harvard University
2014-2024
VA Boston Healthcare System
2013-2024
Brigham and Women's Hospital
2014-2024
Signature Healthcare Brockton Hospital
2009-2024
The University of Texas at Austin
2022-2024
McLean Hospital
2001-2022
Harvard University Press
2006-2022
Hadassah Medical Center
2022
Central Institute of Mental Health
2017
University of Massachusetts Boston
2012
In a preliminary dose-finding study, D-cycloserine, partial agonist at the glycine modulatory site of glutamatergic N-methyl-D-aspartate (NMDA) receptor, improved negative symptoms and cognitive function when added to conventional neuroleptics dose 50 mg/d.Forty-seven patients with schizophrenia meeting criteria for deficit syndrome were randomized mg/d (n=23) or placebo (n=24) their neuroleptic an 8-week, double-blind trial. Clinical assessments performed baseline weeks 1, 2, 4, 6, 8. Serum...
Shape analysis has become of increasing interest to the neuroimaging community due its potential precisely locate morphological changes between healthy and pathological structures. This manuscript presents a comprehensive set tools for computation 3D structural statistical shape analysis. It been applied in several studies on brain morphometry, but can potentially be employed other problems. Its main limitations is necessity spherical topology. The input proposed binary segmentation single...
Orbitofrontal Cortex (OFC) structural abnormality in schizophrenia has not been well characterized, probably due to marked anatomical variability and lack of consistent definitions. We previously reported OFC sulcogyral pattern alteration its associations with social disturbance schizophrenia, but volume psychopathology cognition have investigated. compared chronically treated patients healthy control (HC) subjects, using a novel, reliable parcellation subregions their association cognition,...
Context: Previous magnetic resonance imaging (MRI) findings have demonstrated psychopathological symptom-related smaller gray matter volumes in various cingulate gyrus subregions schizophrenia and bipolar disorder.However, it is unclear whether these abnormalities show a subregional specificity to either disorder they postonset progression.Objective: To determine there are initial progressive volume deficits patients with first-episode (FESZ) affective psychosis (FEAFF, mainly manic) their...
Recent evidence suggests that the cerebellum may play a role in higher cognitive functions and, therefore, an important schizophrenia.The authors used magnetic resonance imaging to measure and vermis volume 15 patients with schizophrenia normal comparison subjects.They found 1) was greater than subjects, 2) white matter significantly correlated severity of positive symptoms thought disorder impairment verbal logical memory, 3) showed trend for more cerebellar hemispheric asymmetry (left...
OBJECTIVE: "Cognitive" circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of core components these circuits, such as caudate nucleus, may result neurobehavioral syndromes similar those lobe. Neuroleptic medication, however, affects size nucleus. For this reason, individuals diagnosed with schizotypal personality disorder offer an ideal group for measurement nucleus because they be genetically related schizophrenia but do not require neuroleptic...
Orbitofrontal alteration in schizophrenia has not been well characterized, likely due to marked anatomical variability. To investigate the presence of such alterations, we evaluated sulcogyral pattern this 'H-shaped' sulcus. Fifty patients with (100 hemispheres) and 50 age- gender-matched control subjects were using 3D high-spatial resolution MRI. Based on a previous study by Chiavaras Petrides (2000), sulcus, which forms boundaries major orbitofrontal gyri, was classified into three types...
Abstract The default mode network (DMN) is a complex dynamic that critical for understanding cognitive function. However, whether topological reconfiguration of the DMN occurs across different brain states, and this potential reorganization associated with prior learning or experience unclear. To better understand temporally changing topology DMN, we investigated both nodal global DMN-topology metrics states. We found changes over time those patterns are Further, organization can be rebuilt...
Abstract Diffusion tensor imaging (DTI) and fiber tractography are useful tools for reconstructing white matter tracts (WMT) in the brain. Previous studies have sought to segment reconstructed WMT into anatomical structures using several approaches, but quantification has been limited extracting mean values of diffusion indices. Delineating schizophrenia is particular interest because hypothesized be a disorder disrupted connectivity, especially between frontal temporal regions In this...
Objective: The striatum receives segregated and integrative white matter tracts from the cortex facilitating information processing in cortico-basal ganglia network. authors examined both types of input striatal associative loop chronic schizophrenia patients healthy control subjects. Method: Structural diffusion MRI scans were acquired on a 3-T system 26 matched Using FreeSurfer, was parcellated into ventrolateral prefrontal dorsolateral subregions. manually its sensorimotor functional...
In this work, we present novel randomized compression algorithms for flat rank-structured matrices with shared bases, known as uniform Block Low-Rank (BLR) matrices. Our main contribution is a technique called tagging, which improves upon the efficiency of basis matrix computation while preserving accuracy compared to alternative methods. Tagging operates on using matrix-vector products and its adjoint, making it particularly advantageous in scenarios where accessing individual entries...
Objective: The mismatch negativity, a negative component in the auditory event-related potential, is thought to index automatic processes involved sensory or echoic memory. authors' goal this study was examine topography of negativity schizophrenia with high-density, 64-channel recording montage.Method: Mismatch evaluated 23 right-handed male patients who were receiving medication and nonschizophrenic comparison subjects matched age, handedness, parental socioeconomic status. Positive...