A5102800373- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Metabolism and Genetic Disorders
- Cardiomyopathy and Myosin Studies
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Cardiovascular Function and Risk Factors
- ATP Synthase and ATPases Research
- Biomedical and Chemical Research
- ECG Monitoring and Analysis
- Pain Management and Treatment
- Muscle Physiology and Disorders
- Glycogen Storage Diseases and Myoclonus
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Amyotrophic Lateral Sclerosis Research
- Cholinesterase and Neurodegenerative Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
University Hospital Carl Gustav Carus
2020-2024
Technische Universität Dresden
2004-2022
German Center for Neurodegenerative Diseases
2022
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2021
Heinrich Heine University Düsseldorf
2017
Klinik und Poliklinik für Neurologie
2013
University Children's Hospital Tübingen
2008
Newcastle University
1995-1996
Johns Hopkins Hospital
1967-1990
Johns Hopkins University
1967-1988
Using a new method for long-term recording of monophasic action potentials from the human heart, we studied in 17 patients effects on ventricular potential duration (APD) three clinically pertinent cycle length perturbations: (1) single extrastimuli, (2) abrupt sustained rate acceleration and deceleration, (3) different steady-state lengths. Results were: (a) APD after extrastimuli at progressively longer lengths were related to extrastimulus with biphasic electrical restitution curve which...
The mitochondrial myopathies typically affect many organ systems and are associated with mutations in DNA (mtDNA) that maternally inherited. However, there is also a sporadic form of myopathy which exercise intolerance the predominant symptom. We studied biochemical molecular characteristics this myopathy.
Defects of the mitochondrial respiratory chain are associated with a great variety clinical disorders. Whilst recognition these conditions is increasing, need for sophisticated biochemical and molecular studies has tended to limit both their investigation diagnosis few specialist centres. Using group 51 patients histochemically, biochemically and/or genetically defined defects, we have examined heterogeneity disorders how they may be investigated most effectively in non-specialist We...
Action potential duration and contractility are reduced following premature excitations, gradually increase as the stimulus interval is lengthened. To examine these phenomena of electrical mechanical restitution in human heart, we simultaneously measured action maximum rate left ventricular pressure five patients undergoing electrophysiological study. Test beats were introduced at varying intervals after last a series steady state intervals. By plotting function test interval, formed curves....
Two patients with myxoma of the left atrium were studied by heart catheterization and cineangiography, diagnosis was confirmed at operation in both cases. An electrocardiographic timing signal on cineradiographs permitted correlation sounds pressure waves movement tumor between ventricle. In early systole, suddenly moved from ventricle to atrium, a notch rising ventricular pressure, prominent c wave, loud, late elements first sound noted. diastole, rapidly through mitral valve, causing an...
Twenty-six adult patients, classified by clinical and catheter criteria into groups of those with normal abnormal left ventricular function, were studied during cardiac catheterization. Right heart pacing was established, dP/dt measured end-catheter manometers. By varying the interval preceding a test beat after periods steady it confirmed that recovery mechanical function (maximum dP/dt) occurs approximately 800 msec (optimum interval) beat. The augmentation maximum first 2 beats an...
Abstract Mutations in the valosin‐containing protein ( VCP ) are known to cause autosomal‐dominant inclusion‐body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD). We report a novel missense mutation (G157R) N‐terminal region gene German family. Family members presented mild moderate proximal muscle weakness, Paget bone, signs early cognitive decline, onset fourth decade. Two family also showed hearing impairment, which was confirmed be sensorineural one person,...
Abstract Defects of the mitochondrial respiratory chain are increasingly being recognized as an important cause neurological disease in humans. In many these patients, biochemical defect results from abnormality genome. Respiratory defects involving complex II, which is entirely encoded by nuclear genome, comparatively rare. We report clinical and findings 2 elderly sisters who presented with late‐onset neurodegenerative disease. both a partial deficiency II (approximately 50% control...
Bridging bronchus (BB) is a rare, congenital bronchial anomaly that frequently associated with cardiac malformations, especially left pulmonary artery sling. It represents an anomalous to the right originating from main bronchus. Discrimination other anomalies important, since BB stenoses due abnormal cartilage rings. This case study describes findings of bronchoscopy, bronchography and multidetector computed tomography (MDCT) in three patients. Bronchoscopy was helpful description severity...
<b>Introduction:</b> We present a family comprising clinically normal mother and two daughters, each with severe encephalopathy onset in late childhood. A third daughter had died previously of an earlier but neuropathologically similar disease. <b>Methods:</b> Sequence analysis the entire mtDNA was carried out muscle, fibroblasts, lymphocytes affected daughters unaffected mother. Biochemical individual respiratory chain enzymes performed on same tissues, several transmitochondrial cybrid...
We tested the afterload and contractile state dependency of three indexes myocardial oxygen consumption (MVO2): total energy requirement (Et), pressure work index (PWI), pressure-volume area (PVA). MVO2 was measured in seven isolated canine hearts at four or five different end-diastolic volumes each settings resistance with contracting isovolumically. In several hearts, contractility also varied by dobutamine infusion. Measured (MMVO2) compared values predicted (PMVO2) index. There always a...
<b>Introduction</b> A total of 83% children report headache during a 6-month period. The estimated 1-year prevalence chronic daily (CDH) in is at least 1 to 2%. Muscle pain associated with severity and chronicity. can be active muscular trigger points, functional concept still remaining controversy. An integrated approach including bio-behavioral management accepted as standard treatment but does not provide sufficient relief all patients. <b>Objective</b> We the individual clinical course...
Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim this study was to investigate cardiac involvement calpainopathy (LGMD2A).Cardiovascular evaluation performed 10 patients with genetically verified LGMD2A by echocardiography, 3 Tesla - cardiovascular magnetic resonance, 24-h electrocardiography recordings heart rate variability (HRV) analysis, and blood pressure recordings.No patient showed impairment left or right ventricular function. One had a...