A5102955351- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Opioid Use Disorder Treatment
- Asthma and respiratory diseases
- Anesthesia and Pain Management
- Advanced biosensing and bioanalysis techniques
- Pain Management and Opioid Use
- Geriatric Care and Nursing Homes
- Gastrointestinal disorders and treatments
- Biochemical and Molecular Research
- Sperm and Testicular Function
- Urologic and reproductive health conditions
- Virus-based gene therapy research
- Suicide and Self-Harm Studies
- Posttraumatic Stress Disorder Research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Diabetes Management and Research
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Neonatal Respiratory Health Research
- Pharmaceutical Practices and Patient Outcomes
- Child and Adolescent Health
- Migration, Health and Trauma
University of California, San Diego
2021-2023
Human Longevity (United States)
2023
Harvard University
2023
Monash University
2020
Hoag Orthopedic Institute
2020
St. Josef-Hospital
2018
Johns Hopkins University
2004-2016
National Institutes of Health
2001
National Institutes of Health Clinical Center
2000
A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. variety modified phenylacetyl groups incorporated into the 5-amino group two thiadiazole rings in an attempt to facilitate additional binding interactions with site GLS. Among newly compounds, 4-hydroxy-N-[5-[4-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide, 2m, potently inhibited...
99mTc-labeled bombesin analogues have shown promise for noninvasive detection of many tumors that express (BN)/gastrin-releasing peptide (GRP) receptors. peptides, however, a tendency to accumulate in the liver and intestines due hepatobiliary clearance as result lipophilicity 99mTc chelates. This makes imaging lesions abdominal area difficult. In this study, we synthesized new high affinity BN analogue, [DTPA1, Lys3(99mTc-Pm-DADT), Tyr4]BN, having built-in pharmacokinetic modifier, DTPA,...
DNA strand breaks produced by the decay of (125)I positioned against a specific site in plasmid via triplex-forming oligonucleotide were studied both immediate vicinity with single nucleotide resolution and whole measuring percentages supercoiled, open-circular linear forms. The localized are distributed within 10 bp each direction from maxima strands just opposite (125)I-dC residue oligonucleotide. distributions two almost symmetrical, agreement geometry pyrimidine motif triplex. We found...
The bombesin (BN)/gastrin-releasing peptide (GRP) receptor is expressed in high density on the cell surface of a variety tumors. This makes receptors accessible as molecular target for detection lesions which they are expressed. In this study, we describe affinity hydrophilic 99mTc-labeled BN analogue, [DTPA1, Lys3(99mTc-Hx-DADT), Tyr4]BN, having diethylenetriaminepentaacetic acid (DTPA), build-in pharmacokinetic modifier, to direct its excretion through urinary system order lower abdominal...
Antigene radiotherapy is our approach to targeting specific sites in the genome by combining highly localized DNA damage produced decay of Auger electron emitters, such as 125I, with sequence-specific action triplex-forming oligonucleotides (TFO). As a model, we used multidrug resistance gene (mdr1) overexpressed and amplified nearly 100 times human KB-V1 carcinoma cell line. Phosphodiester pyrrazolopyrimidine dG (PPG)-modified TFO complementary polypurine-polypyrimidine region mdr1 were...
Military personnel frequently report discontinuing or not pursuing psychiatric treatment despite perceiving a need for services. This study aimed to examine how unmet support among U.S. Army soldiers relates future suicidal ideation (SI) suicide attempt (SA).Mental health and help seeking in the past 12 months were evaluated (N=4,645) who subsequently deployed Afghanistan. Weighted logistic regression models used prospective association of predeployment needs with SI SA during after...
Triplex-forming oligonucleotides (TFOs) show potential for sequence-specific DNA binding and inhibition of gene expression. We have applied this antigene strategy using a TFO incorporating an Auger-emitting radionucleotide, 125I, to study the production double-strand breaks (dsb) in rat aquaporin 5 (rAQP5) cDNA. 125I-TFO bound pCMVrAQP5 plasmid vitro dose-dependent manner formed stable triplexes up 65 degrees C presence 140 mM KCl. Further, resulted predictable dsb when analyzed by Southern...
Zu den gefürchtetsten Komplikationen nach Pankreasresektionen zählen postoperative Arrosionsblutungen, die meist auf dem Boden einer Pankreasfistel entstehen, jedoch auch bei Insuffizienz der Hepatikojejunostomie auftreten können.
Patienten mit exokriner Pankreasinsuffizienz (EPI) benötigen als Substitutionstherapie enteral zugeführte Pankreasenzyme, die hauptsächlich aus Schweine- Pankreata hergestellt werden. Derart hergestellte tierische Enzympräparate werden von der FDA zunehmend kritisch bewertet. Ein Verbot existiert bisher jedoch noch nicht, da es keine Konkurrenzprodukte gibt.
Background: Poorly controlled asthma leads to emergency department (ED) utilization and significant morbidity mortality in pediatric patients with asthma. Inhaled corticosteroids (ICS) reduce exacerbations, ED visits, oral steroid courses for poorly persistent Current literature national guidelines support the initiation of ICS eligible ED. Approximately 21% seen our are initiation, 8% that population started on an Objective: To increase proportion …