A5078987115- Optical Coherence Tomography Applications
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Orthopedic Infections and Treatments
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Sarcoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Hip disorders and treatments
- Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Pain Management and Opioid Use
- Head and Neck Surgical Oncology
- Cancer and Skin Lesions
- Meningioma and schwannoma management
- Opioid Use Disorder Treatment
- Vascular Tumors and Angiosarcomas
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Anesthesia and Pain Management
Hoag Memorial Hospital Presbyterian
2015-2024
Hoag Orthopedic Institute
2015-2024
Orthopedic Institute
2014-2023
Newport Hospital
2016-2023
Université de Rouen Normandie
2015
Hospital for Special Surgery
2013
Barnes-Jewish Hospital
2009-2012
Washington University in St. Louis
2011
Massachusetts General Hospital
2002-2006
Harvard University
2002-2006
An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz.The axial resolution 6 µm tissue had shot-noise-limited performance with maximum sensitivity 98.4 dB.3-dimensional data sets were collected 11 13 seconds macula head respectively are presented to demonstrate potential clinical applications SD-OCT ophthalmology.Additionally, 3-D...
An ultrahigh-speed spectral domain optical coherence tomography (SD-OCT) system is presented that achieves acquisition rates of 29,300 depth profiles/s. The sensitivity SD-OCT and time OCT (TD-OCT) are experimentally compared, demonstrating a 21.7-dB improvement over TD-OCT. In vivo images the human retina presented, ability to acquire high-quality structural with an axial resolution 6 µm at ultrahigh speed ocular exposure level less than 600 µW.
We present the first ultrahigh-resolution optical coherence tomography (OCT) structural intensity images and movies of human retina in vivo at 29.3 frames per second with 500 A-lines frame. Data was acquired a continuous rate 29,300 spectra 98% duty cycle. Two consecutive were coherently summed to improve sensitivity, resulting an effective 14,600 integration time 68 micros. The turn-key source combination two super luminescent diodes combined spectral width more than 150 nm providing 4.5 mW...
An ultra-high-speed spectral domain optical Doppler tomography (SD-ODT) system is used to acquire images of blood flow in a human retina vivo, at 29,000 depth profiles (A-lines) per second and with data acquisition over 99% the measurement time.The phase stability examined image processing algorithms are presented that allow accurate determination bi-directional shifts.Movies retinal acquired 29 frames 1000 A-lines frame time period 3.28 seconds, showing vessel boundaries time-dependent...
Large-head metal-on-metal (MoM) hip arthroplasties have demonstrated poor survival. Damage at the taper-trunnion junction is a contributing factor; however, influence of design not well understood.(1) Does taper type affect fretting, corrosion, and volumetric wear junction? (2) Do types different patterns? (3) larger offset or head diameter increase wear? (4) Is extent fretting corrosion associated with earlier failure?Taper damage in 40 retrieved heads was subjectively graded for determined...
To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, improving health care patients with clinically diagnosed hip or knee osteoarthritis (OA), focus on defining the outcomes that matter most to patients.
A multiphoton microscope employing second-harmonic generation (SHG) and two-photon excited fluorescence (TPF) is used for high-resolution ex vivo imaging of rabbit cornea in a backscattering geometry. Endogenous TPF SHG signals from corneal cells extracellular matrix, respectively, are clearly visible without exogenous dyes. Spectral characterization these upconverted provides confirmation the structural origin both SHG, spectral facilitates separation keratocyte epithelial collagen-rich...
We present a digital spectral shaping technique to reduce the sidelobes (ringing) of axial point-spread function in optical coherence tomography for non-Gaussian-shaped source spectra. The spectra two superluminescent diodes were combined generate spectrum with significant modulation. Images onion cells demonstrate improved image quality turbid biological sample. A quantitative analysis accompanying penalty signal-to-noise ratio is given.
Background: Proximal femoral deformities and overcorrection of the acetabulum both can result in secondary femoroacetabular impingement suboptimal clinical results after periacetabular osteotomy. The purpose present study was to determine rate complications, need for reoperations, radiographic correction, hip function among patients who underwent osteotomy combined head-neck osteochondroplasty as compared with those alone. Methods: Patients or without junction were evaluated retrospectively...
Adverse tissue reactions associated with metal-on-metal (MOM) hips are common in resurfacing and total hip arthroplasty (THA) designs. The etiology of these painful, well-positioned arthroplasties is inconsistently described.The purposes this study were to compare the (1) articular wear rates; (2) histologic findings; (3) synovial response on MRI; (4) graded intraoperative damage between well-positioned, MOM revised for unexplained pain other reasons (5) determine whether presence a taper...
We analyzed the relationship between knee pain after tibial nailing and nail prominence. identified 70 patients in our trauma registry with healed fractures initially treated intramedullary nails. Subjective function were measured visual analog scales Lysholm scores at a mean of 20 months fracture. These compared prominence on postoperative radiographs. More than 49% had pain. was more common women smaller plateau width. Anterior associated increased rest. Patients superior kneeling walking....
There is increasing use of Robotic-Assisted (RA) and personalized alignment techniques in total knee arthroplasty (TKA). The hypothesis this study was that RA TKA would result fewer soft-tissue releases, releases be associated with improved clinical outcomes.
Motion of the sample arm fiber in optical coherence tomography (OCT) systems can dynamically alter polarization state light incident on tissue during imaging, with consequences for both conventional and polarization-sensitive (PS-)OCT.Endoscopic OCT is particularly susceptible to polarization-related effects, since most cases, transverse scanning mechanism involves motion create an image.We investigated effects a system, demonstrate that by referencing backscattered from within measured at...
OBJECTIVE The purpose of this study was to use high‐speed optical coherence tomography (OCT) obtain cross‐sectional images the rat cochlea. STUDY DESIGN AND METHODS cochleae Sprague‐ Dawley rats were imaged within 2 4 hours after death. Specimens prepared by removing bulla expose mesotympanum; some obtained in intact temporal bones removed from cranium. central element an OCT imaging device is a Michelson interferometer combined with low‐coherence light source. This used systems different...
Femoral head-neck junction osteochondroplasty is commonly used to treat femoroacetabular impingement, yet remodeling of the site not well described. We therefore describe bony at and analyze clinical outcomes complications associated with femoral osteochondroplasty. retrospectively reviewed 135 patients (150 hips) who underwent combined hip arthroscopy, surgical dislocation, periacetabular osteotomy, or proximal osteotomy. The minimum followup was 10 months (mean, 22.3 months; range, 10-65...
Posterior pelvic ring reconstruction can be challenging and controversial. The choice regarding whether to reconstruct how reconstitute the is unclear. Many methods provide stability but often are technically difficult require excessive dissection. DESCRIPTION OF SURGICAL TECHNIQUE: This unique reconstructive technique uses anterior aspect of iliac crest with its attached muscle pedicle a biologic scaffold for healing. construct secured screws into posterior column S1 vertebral body spinal...
The systemic bias for aesthetic preferences demonstrated by prior research is thought to reflect neural organisation. Research on preference and laterality has usually been conducted with participants who read a left-to-right Roman script, e.g., English. In order determine if the judgments were influenced habitual scanning direction, we administered geometric test 578 right-handed adults represented range of script experience, i.e., readers (English); right-to-left Arabic readers;...
BACKGROUND AND OBJECTIVE To evaluate the ability of optical coherence tomography (OCT) (a noncontact, high‐resolution imaging technique that generates detailed cross‐sectional images tissue structure) to image and document acute response trauma in larynx. MATERIALS METHODS Porcine larynges were dissected expose vocal cords. Vocal cords imaged with 1310 nanometer (nm) light source a bandwidth 75 nm at 1 frame/second (s). cord injuries simulated by applying topical phenolic acid, injecting...