A5076040824- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Healthcare cost, quality, practices
- Peptidase Inhibition and Analysis
- Family Caregiving in Mental Illness
- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Total Knee Arthroplasty Outcomes
- Molecular Biology Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Antibiotic Use and Resistance
- Clinical practice guidelines implementation
- Diabetes Management and Education
- COVID-19 and healthcare impacts
- Salmonella and Campylobacter epidemiology
- Radiopharmaceutical Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Healthcare Systems and Reforms
- Kruppel-like factors research
- Ectopic Pregnancy Diagnosis and Management
- High Altitude and Hypoxia
- Osteoarthritis Treatment and Mechanisms
Epsom and St Helier University Hospitals NHS Trust
2025
Tarleton State University
2014-2024
National Health Service Wales
2019-2024
Welsh Government
2020-2023
Swansea University
2020-2023
Cardiff University
2020-2023
Cardiff and Vale University Health Board
2020-2023
University of Birmingham
2023
Swansea Bay University Health Board
2023
Cicely Saunders International
2023
To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, improving health care patients with clinically diagnosed hip or knee osteoarthritis (OA), focus on defining the outcomes that matter most to patients.
Patients are experts in their own health and should be treated as equal partners care. Patient-reported outcome measures (PROMs) an effective way of gathering patient feedback can facilitate effectiveness cost-effectiveness analysis to improve decision making service improvement. The PROMs, PREMs & Effectiveness Programme was initiated 2016 aimed develop electronic platform collection PROMs experience (PREMs) from secondary care patients across Wales.
It is undeniable that the NHS, our universal healthcare system, struggling to meet needs and expectations of a population very different from its inception in 1948. Costs are rising inexorably and, yet, patient experience their often not what we would want it be. Inequities still exist, both terms access care clinical outcome. As spend more more, surprisingly little known about extent which meeting goals outcomes really matter patients. Equally, teams stretched facing burnout as emerge...
Aims/Background Rates of both placenta praevia and accreta spectrum (PAS) are rising. There is significant morbidity associated with PAS antenatal detection reduces at delivery. In the UK there a move to centralise care these cases in dedicated units. Incidental diagnosis more common, absence regular screening program. non-specialist hospitals, need consider adjunct confirmatory diagnostics prior referral specialist centres. This important ensure capacity management Ultrasound (US) Magnetic...
Several risk stratification tools were developed to predict disease progression in coronavirus 2019, with no external validation date. We attempted validate three previously published risk-stratification a multicenter study. Primary outcome was composite of development severe 2019 leading ICU admission or death censored at hospital discharge 30 days. collected data from 169 patients. Patients 73 years old (59-82 yr old), 66 (39.1%) female, 57 (33.7%) had one comorbidity, and 80 (47.3%) two...
AHR explores major national and international health issues questions. Our readership includes managers, policy makers clinical staff in organisations including government departments, hospitals, community centres aged-care facilities as well all others with an interest the industry. It enables professionals to keep their fingers on pulse of nation´s decisions know what most influencial commentators decision are thinking. also publishes new research from practitioners - managers clinicians...
Chinese hamster ovary (CHO) cell lines secreting a series of truncated forms human immunodeficiency virus type 1 (HIV-1) IIIB (clone BH10) gp120 were assembled. Using purified glyco-proteins, we demonstrated the functional and structural integrity these truncates by their reactivity with both sCD4 anti-gp120 monoclonal antibodies (MAbs). Deletion V1, V2 V3 regions had minimal effects on CD4 binding, but deletion NH2 terminus affected folding molecule. either V1/V2 or V1/V2/V3 led to enhanced...
The 6th UK Patient Reported Outcome Measures (PROMs) Research Conference was held on the 14 th and 15 of June 2022.Hosted online, it attracted an international audience from locations including Europe, USA, Australia, New Zealand, Caribbean, attended by 381 people with representatives academia, healthcare, patients, industry.Previously hosted Universities Sheffield, Oxford, Birmingham Leeds Beckett, for first time a non-academic organisation, making its inaugural visit to Wales, Welsh Value...
To explore the contribution of avoidable mortality to life expectancy inequalities in Wales during 2002-2020.Observational study.Wales, 2002-20, including early data from COVID-19 pandemic.We used routine statistics for 2002-2020 on population and deaths stratified by age, sex, deprivation quintile cause death. We estimated causes death specific age-categories using Arriaga decomposition method highlight priorities action.Life rose 2002-20 amongst both sexes, driven serial decreases most...
Background Good access to quality primary care in high-income countries can improve population health. Access is however often not equal among socioeconomic groups; our analysis sought explore whether funding, a determinant of service supply, equitably distributed GP practices Wales. Aim We the relationship between funding and deprivation Wales, understand equity current policies. Design & setting obtained data for general Wales 2014 2022 explored distribution using percentage practice...
<h3>ABSTRACT</h3> Characterization of the molecular mutations in colorectal cancers has made great progress since initial report by Fearon and Vogelstein describing a series histologic changes that correlate to mutations. Since 1990, numerous mutational pathways have been associated with 1 or more actionable targets leading precise treatments development cancers, including inherited sporadic ones. The accumulation leads acquisition cancer-promoting qualities such as increased cellular...
<h3>ABSTRACT</h3> Traditional assessment of colorectal cancer includes gross anatomy, routine histology, special stains, and immunohistochemistry. Newer methods, including molecular techniques, can better predict recurrence potential directed treatments. Distinction benign versus malignant neoplasms leads to a series additional tests that are useful in guiding diagnosis, prognosis, treatment. In this article, we focus on the histological grade stage tumor, utilizing College American...
Chief ComplaintThe patient has been referred for a hematology consultation because of marked thrombocytosis levels that had incidentally detected during routine testing performed as part physical examination is prerequisite gamete donation.
Campylobacter organisms are the most commonly reported bacterial pathogens causing foodborne illnesses in world, with jejuni and coli being responsible for 99% of infections.Traditionally, detection species required a special incubation environment as well specific growth media an extended period.The development rapid reliable diagnostic assay would be valuable aid to medical decision process.In this study, our purpose is test sensitivity specificity SYBR Green real-time PCR coli.We used...
I entered general practice in 1998 having originally intended to become a hospital physician. had felt constrained by the medical hierarchy and environment was attracted wild frontiers of community medicine, along with idea longitudinal care. qualified 2000 immediately became partner my training practice, before moving back South Wales valley late 2005. GP trainer, senior big advocate independence. Since 2011, have held other roles too, but that is not important here. Over 20 years life as...