A5074372274- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Advanced biosensing and bioanalysis techniques
- Nanopore and Nanochannel Transport Studies
- Epigenetics and DNA Methylation
- Light effects on plants
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Lipid Membrane Structure and Behavior
- Hip and Femur Fractures
King's College London
2020-2023
Swansea Bay University Health Board
2023
Cicely Saunders International
2023
Cardiff and Vale University Health Board
2023
University of Birmingham
2023
Cardiff University
2023
Institute of Structural and Molecular Biology
2019-2021
University College London
2019-2021
Equipping DNA with hydrophobic anchors enables targeted interaction lipid bilayers for applications in biophysics, cell biology, and synthetic biology. Understanding DNA–membrane interactions is crucial rationally designing functional DNA. Here we study the of hydrophobically tagged membranes using a combination experiments atomistic molecular dynamics (MD) simulations. The duplexes are rendered by conjugation to terminal cholesterol anchor or chemical synthesis charge-neutralized...
Abstract Chemistry is ideally placed to replicate biomolecular structures with tuneable building materials. Of particular interest are molecular nanopores, which transport cargo across membranes, as in DNA sequencing. Advanced nanopores control response triggers, but this cannot be easily replicated biogenic proteins. Here we use nanotechnology build a synthetic gate that opens specific protein. The self‐assembles from six strands form bilayer‐spanning pore, and lid strand comprising...
Abstract Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as methylation play a key role this endeavour. can be controlled by genetic means. Yet there are few chemical tools available for spatial and temporal modulation modification. Herein, we present small‐molecule approach to modulate with light. The strategy uses photo‐tuneable version clinically used drug (5‐aza‐2′‐deoxycytidine) alter catalytic activity...
Abstract Chemistry is ideally placed to replicate biomolecular structures with tuneable building materials. Of particular interest are molecular nanopores, which transport cargo across membranes, as in DNA sequencing. Advanced nanopores control response triggers, but this cannot be easily replicated biogenic proteins. Here we use nanotechnology build a synthetic gate that opens specific protein. The self‐assembles from six strands form bilayer‐spanning pore, and lid strand comprising...
Abstract Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as methylation play a key role this endeavour. can be controlled by genetic means. Yet there are few chemical tools available for spatial and temporal modulation modification. Herein, we present small‐molecule approach to modulate with light. The strategy uses photo‐tuneable version clinically used drug (5‐aza‐2′‐deoxycytidine) alter catalytic activity...
The 6th UK Patient Reported Outcome Measures (PROMs) Research Conference was held on the 14 th and 15 of June 2022.Hosted online, it attracted an international audience from locations including Europe, USA, Australia, New Zealand, Caribbean, attended by 381 people with representatives academia, healthcare, patients, industry.Previously hosted Universities Sheffield, Oxford, Birmingham Leeds Beckett, for first time a non-academic organisation, making its inaugural visit to Wales, Welsh Value...