A5075044886- melanin and skin pigmentation
- Skin Protection and Aging
- Vascular Malformations and Hemangiomas
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Calpain Protease Function and Regulation
- Fungal Infections and Studies
- Hair Growth and Disorders
- Central Venous Catheters and Hemodialysis
- Natural product bioactivities and synthesis
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Nail Diseases and Treatments
- Bioactive natural compounds
- Vascular Malformations Diagnosis and Treatment
Cairo University
2017-2021
University Dermatology
2017
Summary This cross‐sectional multicenter study aimed to evaluate serum CXCL ‐10, as an activity marker for vitiligo, and compare it with other putative tissue markers. Serum ‐10 was compared interferon gamma ( IFN ‐γ), interleukin 6 IL ‐6), ‐17 using ELISA in 55 non‐segmental vitiligo patients (30 active 25 stable) 30 healthy controls. Marginal skin biopsy taken immunohistochemical evaluation of CD 8+T cells ‐10+ve cells. levels ‐17, ‐6 were elevated all controls p < .05). All...
Oral propranolol has become the treatment of choice infantile hemangiomas (IH)s. However, safety systemic is questioned. Topical therapy with 1% been reported to be safe and effective. Intralesional (IL) administration may possibly allow delivery higher drug dosages. To assess efficacy two locally administered routes (topical IL), in comparison its oral use IHs. 45 patients IHs were randomly divided into 3 groups, A, B C (n = 15 each), receiving propranolol, 2 mg/kg/day, topical ointment...
Infantile hemangiomas (IH) are the most common childhood tumors. In 2008, Labreze reported serendipitous effect of oral propranolol on hemangioma and since then it has overshadowed use other therapeutic modalities in treatment IH. The aim this prospective, clinical study was to assess efficacy safety profile at a fixed dose 2 mgkg(-1) 30 patients with problematic Propranolol continued for duration 2-14 months where 60% (n=18) showed final excellent response complete resolution lesion...
NB-UVB has long been the vitiligo management pillar with capability of achieving main treatment outcomes; repigmentation and stabilization. Its stabilizing effect in dark skin debatable. However, randomized controlled trials regarding ability to control disease activity are lacking.To assess comparison systemic corticosteroids, mainstay stabilization, photo-types (III-V).This is a multicenter, placebo-controlled, randomized, prospective study. Eighty patients active nonsegmental (NSV)...
Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables.To assess the effect of different M-K susp variables on clinical outcome in stable vitiligo.This prospective multicenter comparative study included 40 cases with nonsegmental vitiligo. Donor site was either a skin graft noncultured epidermal cell (NCECS) or hair follicle units outer root sheath (ORSHFS). Recipient prepared by cryoblebbing CO2...
Addition of different growth factors to the medium used in autologous melanocyte-keratinocyte transplantation procedure (MKTP) was reported literature. The aim current study comparison response MKTP segmental vitiligo (SV) with and without adding suspension medium. Eighteen cases SV were randomly divided into two groups. In group A: Ham F12 for B: 5 ng/mL recombinant basic fibroblast factor (bFGF) 25 mg/500 mL 3′5′ cyclic adenosine monophosphate (cAMP) added All received NB-UVB twice weekly...
Surgical treatment of vitiligo lesions over the fingers has poor outcome. In this intra-patient comparative study, 12 patients with stable non-segmental (NSV) affecting middle three one hand were included. Three variations used in finger lesions: minipuch grafting, melanocytes keratinocyte transplantation procedure (MKTP) preceded by cryoblebbing or full CO2 laser resurfacing recipient site. Liquid nitrogen was to create blebs 24 hours before therapy. On following day, second treated...
Hypopigmented interface T-cell dyscrasia (HITCD) is a distinct form of lymphoid that may progress to hypopigmented mycosis fungoides (HMF). We compared both diseases as regards their CD4/CD8 phenotype and expression granzyme B tumor necrosis factor-alpha (TNF-α) how these are affected by narrow-band UVB (nb-UVB). The study included 11 patients with HITCD 9 HMF. They received nb-UVB thrice weekly until complete repigmentation or maximum 48 sessions. Pretreatment posttreatment biopsies were...