A5048956276- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Metal complexes synthesis and properties
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Crystal structures of chemical compounds
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Molecular spectroscopy and chirality
- Coordination Chemistry and Organometallics
- Carbohydrate Chemistry and Synthesis
- Advanced MRI Techniques and Applications
- Synthesis and characterization of novel inorganic/organometallic compounds
- Radiopharmaceutical Chemistry and Applications
- Photochemistry and Electron Transfer Studies
- Chemical Synthesis and Characterization
- DNA and Nucleic Acid Chemistry
Tamil Nadu Dr. M.G.R. Medical University
2024
The University of Queensland
2010-2020
ARC Centre of Excellence in Advanced Molecular Imaging
2011-2020
Institute of Bioengineering and Nanotechnology
2020
National Imaging Facility
2010-2019
Monash University
2010-2014
Paradigm Pharmaceuticals (United States)
2004-2011
Parker Hughes Cancer Center
1998-2011
Montreal Neurological Institute and Hospital
1992-2000
McGill University
1992-2000
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithium-7, silicon-29, tin-119, and lead-207 NMR studies of phenyl-substituted Group 4 anionsUlf Edlund, Tore Lejon, Pekka Pyykko, T. K. Venkatachalam, Erwin BuncelCite this: J. Am. Chem. Soc. 1987, 109, 20, 5982–5985Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/ja00254a015https://doi.org/10.1021/ja00254a015research-articleACS...
Thiosemicarbazones possessing electron‐donating and electron‐withdrawing groups were prepared, their spectral characteristics determined. In all cases, the spectra showed that one isomer was formed, allowing further functionalization to molecules of biological interest. We provide NMR data for some thiosemicarbazones semicarbazones. also evidence 2‐pyridyl thiosemicarbazone, syn slowly converts into anti in dimethyl sulfoxide solvent with first‐order kinetics. Molecular modeling density...
There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile <italic>in vivo</italic>, well reducing side-effects an increased standard of care.
Sexually active women represent the fastest growing human immunodeficiency virus (HIV)/acquired syndrome risk group. In an effort to develop a vaginal microbicidal contraceptive potentially capable of preventing HIV transmission as well providing fertility control, we previously reported synthesis novel nonnucleoside inhibitors (NNIs) HIV-1 reverse transcriptase with sperm-immobilizing activity (SIA). To gain further insight into structure-function relationship controlling these two...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR studies of phenylsilyl anions. Evaluation ion pairing and charge distributionErwin Buncel, T. K. Venkatachalam, Bertil Eliasson, Ulf EdlundCite this: J. Am. Chem. Soc. 1985, 107, 2, 303–306Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00288a003https://doi.org/10.1021/ja00288a003research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence on covalency and monomeric structure of phenyl silyl lithiums in ethereal solutions from scalar 29Si-6(7)Li couplingsUlf Edlund, Tore Lejon, T. Krishnan Venkatachalam, Erwin BuncelCite this: J. Am. Chem. Soc. 1985, 107, 22, 6408–6409Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://doi.org/10.1021/ja00308a051RIGHTS & PERMISSIONSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacteristics of Bead Copolymers and Ion-Exchange Resins Prepared from Polystyrene Cross Linked with Pure Divinyl MonomersRichard H. Wiley, J. K. Allen, S. P. Chang, E. Musselman, T. VenkatachalamCite this: Phys. Chem. 1964, 68, 7, 1776–1779Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July...
Abstract A detailed NMR investigation of the chemical shifts hydrogen and carbon atoms associated with structure naturally occurring alkaloid colchicine was conducted using high field NMR. Initially, experimental for in chloroform DMSO were compared to values calculated density functional theory (DFT). There significant deviations observed solvent, but these only slight solution. Dilution solution changed improved agreement DFT calculations, suggesting self-aggregation at higher...
Detergent-based vaginal microbicides, in addition to their high contraceptive failure rates, cause mucosal erosion and local inflammation that might increase the risk of heterosexual human immunodeficiency virus (HIV) transmission. In a systematic effort identify microbicide potentially capable preventing sexual transmission HIV as well providing fertility control, series novel aryl phosphate derivatives 5-bromo-6-methoxy-3'-azido-3'-deoxythymidine (AZT; zidovudine) were synthesized examined...
ABSTRACT Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been designed based on structure NNI pocket and tested for anti-HIV activity. Our lead DABO derivative, 5-isopropyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1 H )-one, elicited inhibitory activity against purified recombinant HIV RT abrogated replication in peripheral blood...